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S288

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

cannabis use, and the rest of them (

n

= 6; 24%) were tested pos-

itive. These results show a high significant correlation between

cannabis use and medication adherence (

P

= 0.009). Besides, medi-

cation adherence is strongly associated with a high socioeconomic

status (

P

= 0.005).

Conclusion

Cannabis use has amajor effect on the non-adherence

to medication treatment for schizophrenia. These results could be

more effective if it addresses issues of cannabis use with patients

throughout the early years of treatment.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.613

EW496

Virtual reality insights into

schizophrenic patients’ way to

interpret an Avatar’s help

E. Brunet-Gouet

1 ,

, A. Oker

2

, Z. Berrada-Baby

2

, M. Courgeon

3

,

M. Urbach

4

, N. Bazin

4

, J.C. Martin

5

, M.A. Amorim

6

, P. Roux

1

,

C. Passerieux

1

1

Centre hospitalier de Versailles, université Versailles-Saint-Quentin,

Psychiatrie/HANDIRESP, Le Chesnay, France

2

Centre hospitalier de Versailles, Psychiatrie/HANDIRESP, Le

Chesnay, France

3

Université Paris-Sud, université Bretagne-Sud, LIMSI UPR3251-

LabSTICC- UMR6285, Orsay, France

4

Centre hospitalier de Versailles, Psychiatrie, Le Chesnay, France

5

Université Paris Sud, LIMSI UPR3251, Orsay, France

6

Université Paris Sud, CIAMS, Orsay, France

Corresponding author.

With regards to the neurocognitive deficits and cognitive bias of

schizophrenic disorders, it may be hypothesized that these patients

suffer a deficit in recognizing helping intentions in others. To inves-

tigate help recognition, new technologies allowing to control an

interaction with virtual affective agents were used with an adap-

tation of a previously described card-guessing paradigm (project

COMPARSE ANR-11-EMCO-0007). We investigated whether the

same game proposed successively by two virtual agents asking

either empathetic (i.e. on the subject’s feelings) or non-empathetic

(i.e. on technical aspects of the game) questions to the participant

would elicit different interpretations on their intentions. Depend-

ent variables consisted of monetary allocation to the virtual agent,

of questionnaires assessing the agent’s help, interest, attention,

etc. A group of 20 individuals with schizophrenia and one of 20

healthy controls, matched on gender, with comparable age, esti-

mated verbal-IQ and educational level were recruited. The healthy

subjects’ ratings of the virtual agent’s behavior demonstrated that

they interpreted empathetic questioning as helping and rewarded

it positively with an increased monetary allocation. Schizophrenic

patients had a qualitatively reduced perception of the differences

between the two agents. Only the rating concerning the “inter-

est/attention” of the agent toward them exhibited medium effect

size when contrasting conditions. Hypothetically, schizophrenic

patients take into account the fact they are the object of another’s

attention, but may fail to infer the intentional meaning and to

provide an increased monetary allocation.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.614

EW497

Clinical experience with aripiprazole

long-acting injection

M.P. Calvo Rivera

1 ,

, B. Girela Serrano

2

, A. Porras Segovia

1

,

L. Gutiérrez Rojas

1

1

San Cecilio university hospital, psychiatry service, Granada, Spain

2

Santa Ana hospital, psychiatry service, Motril-Granada, Spain

Corresponding author.

Introduction

Aripiprazole long-acting injection is the latest long-

acting injectable (LAI) antipsychotic medication released in the

market which requires a monthly injection.

Objectives

The aimof our study is to present our experience in the

use of Aripiprazole long-acting injection as maintenance therapy in

patients with schizophrenia and other psychotic disorders.

Methodology

Our sample consists of 20 patients who started

treatment with long acting aripiprazole during the last 6 months of

its release. Validated scales for collecting information on sociode-

mographic, clinical evaluation (CGI scale), quality of life (health

questionnaire SF-36) and function (Sheehan Disability Inventory

and social relationship scale SBS) were used.

Results

The health condition of the patients was generally good

and 68% reported feeling better than during the last year. Social

functioningwas adequate (level 1 or 2) in about 70% of the patients.

Social, employment and family’s disability was mild in 57% of cases,

the average stress’ perception was 23% and the average social

support perception was 72%. Regarding the clinical evaluation, in

comparison to the initiation of the treatment 18% of the patients

were slightly better, 45% moderately better and 36% much better.

Conclusion

A remarkable clinical improvement was observed,

maintaining good health, with an acceptable level of functionality.

This study shows that the incorporation of long-acting Aripiprazole

to the treatment of our sample has been a significant improvement

in overall functioning of the patient.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.615

EW498

Assessing theory of mind in

schizophrenia during a collaborative

game

M. Champagne-Lavau

1 ,

, A. Michelas

1

, C. Faget

2

, C. Portes

1

,

M. Klein

1

, L. Boyer

3

, C. Lanc¸ on

2

1

Aix-Marseille université, CNRS- LPL- UMR 7309, Aix-en-Provence,

France

2

La Conception university hospital, department of psychiatry,

Marseille, France

3

Aix-Marseille université, EA 3279- public health- chronic diseases

and quality of life research unit, Marseille, France

Corresponding author.

Introduction

While Theory of mind (ToM) impairments have

been well established in schizophrenia (SZ), very few studies have

investigated these impairments during social interactions. How-

ever, in daily life the attribution of mental states to others (ToM) is

most often implicit and spontaneous whereas classical ToM tasks

rely on explicit, deliberate and cognitively-demanding reasoning.

Objective

The aim of the present study was to fully characterize

ToM ability in schizophrenia by investigating this ability during a

collaborative game.

Methods

Ten individuals with schizophrenia (SZ) and ten healthy

control (HC) participantswere recruited. Patients’ severity of symp-

toms was measured using the PANSS. All participants were asked to

play a collaborative game with an experimenter. During this game,

the aim of the participant was to transfer a given route fromhis/her

map to his/her interlocutor. The prosodic focus marking was used

as a linguistic marker of ToM. Participants were also submitted to

a classical ToM task requiring explicit attribution of mental states

and to a neuropsychological evaluation.

Results

The results showed that, by contrast to HC participants,

SZ patients did not produce prosodic focus marking revealing dif-

ficulties to attribute knowledge to their interlocutor during the

collaborative game. SZ patients were impaired on both explicit and

implicit ToM assessment. No correlation was found between the