European Psychiatry - Volume 33 - March 2016

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S288 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348
cannabis use, and the rest of them ( n = 6; 24%) were tested pos-
itive. These results show a high significant correlation between
cannabis use and medication adherence (P = 0.009). Besides, medi-
cation adherence is strongly associated with a high socioeconomic
status (P = 0.005).
Conclusion Cannabis use has amajor effect on the non-adherence
to medication treatment for schizophrenia. These results could be
more effective if it addresses issues of cannabis use with patients
throughout the early years of treatment.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW496
Virtual reality insights into
schizophrenic patients’ way to
interpret an Avatar’s help
E. Brunet-Gouet ∗, A. Oker , Z. Berrada-Baby , M. Courgeon ,
M. Urbach , N. Bazin , J.C. Martin , M.A. Amorim , P. Roux ,
C. Passerieux
1 Centre hospitalier de Versailles, université Versailles-Saint-Quentin,
Psychiatrie/HANDIRESP, Le Chesnay, France
2 Centre hospitalier de Versailles, Psychiatrie/HANDIRESP, Le
Chesnay, France
3 Université Paris-Sud, université Bretagne-Sud, LIMSI UPR3251-
LabSTICC- UMR6285, Orsay, France
4 Centre hospitalier de Versailles, Psychiatrie, Le Chesnay, France
5 Université Paris Sud, LIMSI UPR3251, Orsay, France
6 Université Paris Sud, CIAMS, Orsay, France
∗ Corresponding author.
With regards to the neurocognitive deficits and cognitive bias of
schizophrenic disorders, it may be hypothesized that these patients
suffer a deficit in recognizing helping intentions in others. To inves-
tigate help recognition, new technologies allowing to control an
interaction with virtual affective agents were used with an adap-
tation of a previously described card-guessing paradigm (project
COMPARSE ANR-11-EMCO-0007). We investigated whether the
same game proposed successively by two virtual agents asking
either empathetic (i.e. on the subject’s feelings) or non-empathetic
(i.e. on technical aspects of the game) questions to the participant
would elicit different interpretations on their intentions. Depend-
ent variables consisted of monetary allocation to the virtual agent,
of questionnaires assessing the agent’s help, interest, attention,
etc. A group of 20 individuals with schizophrenia and one of 20
healthy controls, matched on gender, with comparable age, esti-
mated verbal-IQ and educational level were recruited. The healthy
subjects’ ratings of the virtual agent’s behavior demonstrated that
they interpreted empathetic questioning as helping and rewarded
it positively with an increased monetary allocation. Schizophrenic
patients had a qualitatively reduced perception of the differences
between the two agents. Only the rating concerning the “inter-
est/attention” of the agent toward them exhibited medium effect
size when contrasting conditions. Hypothetically, schizophrenic
patients take into account the fact they are the object of another’s
attention, but may fail to infer the intentional meaning and to
provide an increased monetary allocation.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW497
Clinical experience with aripiprazole
long-acting injection
M.P. Calvo Rivera ∗, B. Girela Serrano , A. Porras Segovia ,
L. Gutiérrez Rojas
1 San Cecilio university hospital, psychiatry service, Granada, Spain
2 Santa Ana hospital, psychiatry service, Motril-Granada, Spain
∗ Corresponding author.
Introduction Aripiprazole long-acting injection is the latest long-
acting injectable (LAI) antipsychotic medication released in the
market which requires a monthly injection.
Objectives The aimof our study is to present our experience in the
use of Aripiprazole long-acting injection as maintenance therapy in
patients with schizophrenia and other psychotic disorders.
Methodology Our sample consists of 20 patients who started
treatment with long acting aripiprazole during the last 6 months of
its release. Validated scales for collecting information on sociode-
mographic, clinical evaluation (CGI scale), quality of life (health
questionnaire SF-36) and function (Sheehan Disability Inventory
and social relationship scale SBS) were used.
Results The health condition of the patients was generally good
and 68% reported feeling better than during the last year. Social
functioningwas adequate (level 1 or 2) in about 70% of the patients.
Social, employment and family’s disability was mild in 57% of cases,
the average stress’ perception was 23% and the average social
support perception was 72%. Regarding the clinical evaluation, in
comparison to the initiation of the treatment 18% of the patients
were slightly better, 45% moderately better and 36% much better.
Conclusion A remarkable clinical improvement was observed,
maintaining good health, with an acceptable level of functionality.
This study shows that the incorporation of long-acting Aripiprazole
to the treatment of our sample has been a significant improvement
in overall functioning of the patient.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW498
Assessing theory of mind in
schizophrenia during a collaborative
game
M. Champagne-Lavau ∗, A. Michelas , C. Faget , C. Portes ,
M. Klein , L. Boyer , C. Lanc¸ on
1 Aix-Marseille université, CNRS- LPL- UMR 7309, Aix-en-Provence,
France
2 La Conception university hospital, department of psychiatry,
Marseille, France
3 Aix-Marseille université, EA 3279- public health- chronic diseases
and quality of life research unit, Marseille, France
∗ Corresponding author.
Introduction While Theory of mind (ToM) impairments have
been well established in schizophrenia (SZ), very few studies have
investigated these impairments during social interactions. How-
ever, in daily life the attribution of mental states to others (ToM) is
most often implicit and spontaneous whereas classical ToM tasks
rely on explicit, deliberate and cognitively-demanding reasoning.
Objective The aim of the present study was to fully characterize
ToM ability in schizophrenia by investigating this ability during a
collaborative game.
Methods Ten individuals with schizophrenia (SZ) and ten healthy
control (HC) participantswere recruited. Patients’ severity of symp-
toms was measured using the PANSS. All participants were asked to
play a collaborative game with an experimenter. During this game,
the aim of the participant was to transfer a given route fromhis/her
map to his/her interlocutor. The prosodic focus marking was used
as a linguistic marker of ToM. Participants were also submitted to
a classical ToM task requiring explicit attribution of mental states
and to a neuropsychological evaluation.
Results The results showed that, by contrast to HC participants,
SZ patients did not produce prosodic focus marking revealing dif-
ficulties to attribute knowledge to their interlocutor during the
collaborative game. SZ patients were impaired on both explicit and
implicit ToM assessment. No correlation was found between the