Table of Contents Table of Contents
Previous Page  777 / 812 Next Page
Information
Show Menu
Previous Page 777 / 812 Next Page
Page Background

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

S773

and menstrual disorders. During hospitalization, aripiprazole is

introduced while paliperidone is progressively decreased. Antipsy-

chotic were prescribed because delusions of reference and auditory

pseudo-hallucinations arose suddenly in a woman without history

of previous psychotic breaks. Before treatment with aripiprazole,

prolactinaemia was 156,96 ng/mL (pregnancy test was negative)

and after stopping, paliperidone was 23,60 ng/mL.

Discussion

If hyperprolactinaemia symptoms appeared

(galactorrhea

. . .

), aripiprazole is a good option if antipsychotic

treatment is required. In this case, paliperidone was decreased

slowly, while aripiprazole was increased, until minimum effective

dose was reached.

Conclusions

Hyperprolactinaemia is a common side effect in

antipsychotic treatments and if symptoms appeared aripiprazole

is a good option.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.2315

EV1331

Delirium associated with sertraline, a

case report

N. Salgado

1 ,

, S. Benavente

2

, B. Macias

1

, M. Duran

1

, P. Leganes

1

1

Hospital Dr. Rodriguez Lafora, Psiquiatria, Madrid, Spain

2

Hospital Universitario 12 de Octubre, psiquiatria, Madrid, Spain

Corresponding author.

Introduction

Delirium is a clinical entity consisting of acute loss

of consciousness, with attention deficit and fluctuating evolution.

Antidepressive medication can cause these symptoms or worsen

them.

Case report

We report the case of a 84-year-old blind female who

was diagnosed of delirium in relation to intoxication with sertra-

line. The patient was admitted into a short-stay psychiatric unit

for three days. She presented behavioural disturbances consist-

ing in auto and heteroaggressive behaviour, altered consciousness

and visual hallucinations (rocks, turtles). When dosage of sertraline

was doubled from 50mg/day to 100mg/day visual hallucinations

started. There were not other medical causes found, so sertraline

was suspended, achieving clinical improvement.

Discussion

This case report shows how a patient with antide-

pressive treatment can display delirium. The three main causes of

delirium that are infections, side effects and methabolic syndrome.

Conclusions

In the case of treating a patient with delirium, the

presence of previous illness has to be investigated. It is indispens-

able to describe the presence of previous illness, medication and

recent changes of the dosages in the medical history in a patient

with Sertraline.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.2316

EV1332

Drug eruption due to bupropion, a

case report

N. Salgado

1 ,

, S . B

enavente

2 , J.M

. Coll

3 , A. V

ives

1

1

Hospital Dr. Rodriguez Lafora, Psiquiatria, Madrid, Spain

2

Hospital Universitario 12 de Octubre, Psiquiatria, Madrid, Spain

3

Hospital Universitario La Paz, Psiquiatria, Madrid, Spain

Corresponding author.

Introduction

We present a clinical case of eruption caused by the

use of bupropion. Bupropion is known to cause hypersensitivity

reactions.

Case report

We report the case of a 48-year-old female who was

diagnosed of depressive disorder. She went to emergency because

a few days after prescribing bupropion (150mg/24 h) scaly skin

eruptions were found distributed along the skin. In the present

case, after its introduction, bupropion was found to be a probable

etiological agent. The patient was successfully treated with cor-

ticosteroids. Because of that, bupropion dosage was stopped and

replaced with fluoxetine. No remissions and exacerbations were

noticed in a month’s follow up.

Discussion

In this case report, we present a patient with an

eruption related to bupropion. The aetiological spectrum of erup-

tion include drugs, infectious agents and food additives. Drugs

attributing eruption include nonsteroidal anti-inflammatory drugs,

antibiotics, and anti-epileptic drugs, antidepressive medication

amongst others.

Conclusions

No specific diagnostic criterion exists for eruption

and the diagnosis is purely based on clinical presentation. Diag-

nostic features, which suggest eruption, are the acute onset (or

recurrent nature) and skin lesions.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.2317

EV1333

A “Newly Discovered in Romania”

atypical antipsychotic prolonged

release treatment for patient with

schizophrenia. First results of a

naturalistic study with recently

approved paliperidone palmitate

M. Sarpe

1 ,

, M. Ladea

2

, M. Bran

3

1

Focsani, Romania

2

“Obregia” Hospital of Psychiatry, III Ward, Bucharest, Romania

3

“Coltea” Hospital, Outpatient Care Unit, Bucharest, Romania

Corresponding author.

Introduction

Intramuscular paliperidone palmitate is a long-

acting atypical antipsychotic, which has only been marketed

in Romania from march 2015 as a free of charge medica-

tion/subsidized for the acute and maintenance treatment of

schizophrenia in adults.

Objectives and aims

To determine the efficacy and tolerability of

paliperidone palmitate in 12 patients with schizophrenia in an out-

patient care unit, taking into account the limited clinical experience

with this product in Romania.

Methods

The study was performed in an outpatient care unit.

Data was collected from medical records of patients started on

paliperidone palmitate between March and June 2015. This time

period was selected because we wanted to have at least a 6-month

period of evaluating these patients. Some of the patients were

previously on risperidone long-acting injection (in Romania the

advantages of a 1-month injection instead of 2 and the fact that

the medication does not need to be held in a refrigerator are 2

important factors that can increase the compliance of the patients).

Others were treated with other long-acting antipsychotics (flupen-

tixol). The rest were patients treated before with risperidone, with

good response, but with problems of non-compliance.

Results

None of the patients treated with paliperidone palmitate

relapsed. Some of themhad, atmaximumdose, minor extrapyrami-

dal symptoms that disappeared when we lowered the dose. Taking

into account the lack of insight and the non-compliance of patients

with schizophrenia, this treatment seems to be extremely valuable,

maybe more in this kind of cases, in outpatient care units.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.2318