European Psychiatry - Volume 33 - March 2016

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S772 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805
8 Servicio Murciano de Salud, Hospital General Universitario Santa
Lucía, Cartagena, Murcia, Spain
∗ Corresponding author.
Introduction Electroconvulsive therapy (ECT) is an effective
depression treatment, but it has potential cognitive side effects.
Bitemporal ECT has been traditionally used, but in recent decades,
right unilateral (RUL) electrode placement has been proposed to
decrease the cognitive side effects of ECT. Ultrabrief pulse (UBP)
right unilateral (RUL) ECT is an increasingly used treatment option
that can potentially combine efficacy with lesser cognitive side
effects.
Objectives To evaluate whether ultrabrief pulse (UBP) right uni-
lateral (RUL) electroconvulsive therapy (ECT) is as effective as brief
pulse (BP) RUL ECT in addition to cause lesser cognitive side effects.
Material and methods A search is performed in the available sci-
entific literature on systematic review and meta-analysis of the
subject under study, through the database PubMed.
Results – Current evidence supports the efficacy of right unilat-
eral (RUL) electroconvulsive therapy (ECT) given with an ultrabrief
pulse width in the treatment of depression;
– ultrabrief pulse RUL ECT leads to lesser cognitive side effects than
traditional forms of ECT;
– ultrabrief pulse RUL ECT may be slightly less effective than tra-
ditional forms of ECT.
Conclusions BP compared with UBP RUL ECT was slightly more
efficacious in treating depression and required fewer treatment
sessions, but led to greater cognitive side effects. The decision of
whether to use BP or UBP RUL ECT should be made on an indi-
vidual patient basis and should be based on a careful weighing of
the relative priorities of efficacy versus minimization of cognitive
impairment.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1328
Acute pancreatitis and
olanzapine–valproate association: A
pilot study
M.G. Ravel ∗, E. De Vivo , F. Marmo , F. Gucci
1 Villa Camaldoli Alma Mater SPA, Psychiatrist, Psychodynamic
Integrated Psychiatry Department, Napoli, Italy
2 Villa Camaldoli Alma Mater SPA, Head Psychiatrist, Psychodynamic
Integrated Psychiatry Department, Napoli, Italy
∗ Corresponding author.
Introduction Drugs are responsible for 0.1–2% of acute pancreati-
tis incidents, which is characterized by the onset of parenchymal
fat necrosis with inflammation in a previously healthy individual
(Jones, 2015). Elevation of serum amylase is an effective marker
of disease (de Berardinis, 1999). Valproic acid induces acute pan-
creatitis as a direct toxic effect of free radicals on the pancreatic
tissue (Kaurich, 2008). Most cases of pancreatitis occurred within
6 months after the start of therapy with one or more antipsy-
chotic agents (Koller, 2003). The temporal relationship of the onset
of pancreatitis with the start of drug therapy further supports a
cause-and-effect relationship (Alonso-Alonso, 2006). Some clinical
reports noticed sporadic acute pancreatitis in patients taking both
valproate and olanzapine.
Methods We selected 50 psychiatric inpatients taking both olan-
zapine and valproate, presenting acute and aspecific gastroenteric
symptomatology. We measured out their serum amylase and the
time between drug prescription and start of gastroenteric simp-
tomatology.
Results and conclusions A large part of subjects associated olanza-
pine and valproate over 6 months before gastroenteric symptoms
would start. Elevation of serum amylase rates does not sug-
gest a link between this drug association and acute pancreatitis.
Meanwhile, larger populations surveys could be helpful in early
detecting sporadic cases.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1329
Psychiatry heal thyself: a lifestyle
intervention targeting mental health
staff to enhance uptake of lifestyle
interventions for people prescribed
antipsychotic medication
S. Rosenbaum ∗, A. Watkins , P.B. Ward , D. Pearce ,
K. Fitzpatrick , J. Curtis
1 University of New South Wales, Psychiatry, Sydney, Australia
2 South Eastern Sydney Local Health District, Keeping the Body In
Mind Programme, Sydney, Australia
∗ Corresponding author.
Introduction People experiencing severe mental illness (SMI)
face a shortened life expectancy of up to 20 years, primarily due
to preventable cardiovascular (CV) diseases. Lifestyle interventions
are effective in reducing CV risk, yet examples of service-wide inter-
ventions are lacking. Staff culture remains a barrier to the successful
implementation of lifestyle interventions. The Keeping the Body in
Mind (KBIM) program, established by SESLHD (Australia), aims to
close the gap in life expectancy through multidisciplinary teams,
including clinical nurse consultants, dieticians, exercise physiol-
ogists, and peer support workers. Prior to the KBIM rollout, an
individualized lifestyle intervention called Keeping Our Staff In
Mind (KoSiM) was offered to all district mental health staff.
Objective KoSiM examined the effectiveness of a staff inter-
vention to improve physical health, confidence, knowledge and
attitudes of mental health staff.
Methods Mental health staffs were invited to participate in an
online survey and a 4-week individualized intervention including
personalised health screening and lifestyle advice, with a 16-week
follow-up. Outcomes assessed included: attitudes, confidence and
knowledge regarding metabolic health, weight, waist circumfer-
ence (WC), blood pressure, sleep, diet, physical activity and exercise
capacity.
Results Of a total of 702 staff, 204 completed the survey (29%).
Among those completing the survey, 154 staff (75%) participated
in the intervention. A mean decrease in waist circumference of
2 ± 2.7 cm, (P < 0.001) was achieved. Among staffs that were over-
weight or obese at baseline, 75% achieved a decrease in WC.
Conclusion Improving staff culture regarding physical health
interventions is an important step in integrating lifestyle interven-
tions into routine care.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1330
Prolactine borderline, a case report
N. Salgado ∗ acias enavente uiz
1 Hospital Dr. Rodriguez Lafora, Psiquiatria, Madrid, Spain
2 Hospital Universitario 12 de Octubre, Psiquiatria, Madrid, Spain
∗ Corresponding author.
Introduction It is known that antipsychotic drugs can increase
prolactinaemia, we report a case in which the use of aripiprazole
after treatment with paliperidone helped regaining normality lev-
els.
Case report During treatment with PALiperidone12mg/day the
patient, a 27-year-old female diagnosed with borderline person-
ality disorder, developed hyperprolactinaemia with galactorrhea