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S772

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

8

Servicio Murciano de Salud, Hospital General Universitario Santa

Lucía, Cartagena, Murcia, Spain

Corresponding author.

Introduction

Electroconvulsive therapy (ECT) is an effective

depression treatment, but it has potential cognitive side effects.

Bitemporal ECT has been traditionally used, but in recent decades,

right unilateral (RUL) electrode placement has been proposed to

decrease the cognitive side effects of ECT. Ultrabrief pulse (UBP)

right unilateral (RUL) ECT is an increasingly used treatment option

that can potentially combine efficacy with lesser cognitive side

effects.

Objectives

To evaluate whether ultrabrief pulse (UBP) right uni-

lateral (RUL) electroconvulsive therapy (ECT) is as effective as brief

pulse (BP) RUL ECT in addition to cause lesser cognitive side effects.

Material and methods

A search is performed in the available sci-

entific literature on systematic review and meta-analysis of the

subject under study, through the database PubMed.

Results

– Current evidence supports the efficacy of right unilat-

eral (RUL) electroconvulsive therapy (ECT) given with an ultrabrief

pulse width in the treatment of depression;

– ultrabrief pulse RUL ECT leads to lesser cognitive side effects than

traditional forms of ECT;

– ultrabrief pulse RUL ECT may be slightly less effective than tra-

ditional forms of ECT.

Conclusions

BP compared with UBP RUL ECT was slightly more

efficacious in treating depression and required fewer treatment

sessions, but led to greater cognitive side effects. The decision of

whether to use BP or UBP RUL ECT should be made on an indi-

vidual patient basis and should be based on a careful weighing of

the relative priorities of efficacy versus minimization of cognitive

impairment.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.2312

EV1328

Acute pancreatitis and

olanzapine–valproate association: A

pilot study

M.G. Ravel

1 ,

, E. De Vivo

1

, F. Marmo

1

, F. Gucci

2

1

Villa Camaldoli Alma Mater SPA, Psychiatrist, Psychodynamic

Integrated Psychiatry Department, Napoli, Italy

2

Villa Camaldoli Alma Mater SPA, Head Psychiatrist, Psychodynamic

Integrated Psychiatry Department, Napoli, Italy

Corresponding author.

Introduction

Drugs are responsible for 0.1–2% of acute pancreati-

tis incidents, which is characterized by the onset of parenchymal

fat necrosis with inflammation in a previously healthy individual

(Jones, 2015). Elevation of serum amylase is an effective marker

of disease (de Berardinis, 1999). Valproic acid induces acute pan-

creatitis as a direct toxic effect of free radicals on the pancreatic

tissue (Kaurich, 2008). Most cases of pancreatitis occurred within

6 months after the start of therapy with one or more antipsy-

chotic agents (Koller, 2003). The temporal relationship of the onset

of pancreatitis with the start of drug therapy further supports a

cause-and-effect relationship (Alonso-Alonso, 2006). Some clinical

reports noticed sporadic acute pancreatitis in patients taking both

valproate and olanzapine.

Methods

We selected 50 psychiatric inpatients taking both olan-

zapine and valproate, presenting acute and aspecific gastroenteric

symptomatology. We measured out their serum amylase and the

time between drug prescription and start of gastroenteric simp-

tomatology.

Results and conclusions

A large part of subjects associated olanza-

pine and valproate over 6 months before gastroenteric symptoms

would start. Elevation of serum amylase rates does not sug-

gest a link between this drug association and acute pancreatitis.

Meanwhile, larger populations surveys could be helpful in early

detecting sporadic cases.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.2313

EV1329

Psychiatry heal thyself: a lifestyle

intervention targeting mental health

staff to enhance uptake of lifestyle

interventions for people prescribed

antipsychotic medication

S. Rosenbaum

1 ,

, A. Watkins

2

, P.B. Ward

1

, D. Pearce

2

,

K. Fitzpatrick

2

, J. Curtis

2

1

University of New South Wales, Psychiatry, Sydney, Australia

2

South Eastern Sydney Local Health District, Keeping the Body In

Mind Programme, Sydney, Australia

Corresponding author.

Introduction

People experiencing severe mental illness (SMI)

face a shortened life expectancy of up to 20 years, primarily due

to preventable cardiovascular (CV) diseases. Lifestyle interventions

are effective in reducing CV risk, yet examples of service-wide inter-

ventions are lacking. Staff culture remains a barrier to the successful

implementation of lifestyle interventions. The Keeping the Body in

Mind (KBIM) program, established by SESLHD (Australia), aims to

close the gap in life expectancy through multidisciplinary teams,

including clinical nurse consultants, dieticians, exercise physiol-

ogists, and peer support workers. Prior to the KBIM rollout, an

individualized lifestyle intervention called Keeping Our Staff In

Mind (KoSiM) was offered to all district mental health staff.

Objective

KoSiM examined the effectiveness of a staff inter-

vention to improve physical health, confidence, knowledge and

attitudes of mental health staff.

Methods

Mental health staffs were invited to participate in an

online survey and a 4-week individualized intervention including

personalised health screening and lifestyle advice, with a 16-week

follow-up. Outcomes assessed included: attitudes, confidence and

knowledge regarding metabolic health, weight, waist circumfer-

ence (WC), blood pressure, sleep, diet, physical activity and exercise

capacity.

Results

Of a total of 702 staff, 204 completed the survey (29%).

Among those completing the survey, 154 staff (75%) participated

in the intervention. A mean decrease in waist circumference of

2

±

2.7 cm, (

P

< 0.001) was achieved. Among staffs that were over-

weight or obese at baseline, 75% achieved a decrease in WC.

Conclusion

Improving staff culture regarding physical health

interventions is an important step in integrating lifestyle interven-

tions into routine care.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.2314

EV1330

Prolactine borderline, a case report

N. Salgado

1 ,

, B . M

acias

1 , S. B

enavente

2 , R. R

uiz

1

1

Hospital Dr. Rodriguez Lafora, Psiquiatria, Madrid, Spain

2

Hospital Universitario 12 de Octubre, Psiquiatria, Madrid, Spain

Corresponding author.

Introduction

It is known that antipsychotic drugs can increase

prolactinaemia, we report a case in which the use of aripiprazole

after treatment with paliperidone helped regaining normality lev-

els.

Case report

During treatment with PALiperidone12mg/day the

patient, a 27-year-old female diagnosed with borderline person-

ality disorder, developed hyperprolactinaemia with galactorrhea