European Psychiatry - Volume 33 - March 2016

772 / 812

S768 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805
Background Pharmacological treatments for chronic diseases
cause side effects. It is important to identify which of these effects
could be avoided because it is a cause to drop the treatment. In the
chronic psychiatric illness, one of the problems is the induction of
changes in prolactin (PRL) serum.
Purpose Reviewof the literature that has beenpublished to assess
the association between different types of antipsychotic drugs and
prolactin levels.
Method Literature search on PubMed, NCBI literature in the last
three years using MeSH terms: “prolactin” and “antipsychotics”.
Conclusions The increase of prolactin is a common effect poorly
studied in the past. After several studies have been able to achieve
treatments, called “atypical”, which cause less effect on this sub-
stance. For example, asenapine, olanzapine and zyprasidone have
a slight effect on PRL levels. Aripripazole could even result in lower
levels probably by partial agonism on dopamine receptors. There-
fore, we have to make a good clinical practice taking into account
the effectiveness and tolerance and interpersonal variation.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1315
Therapeutic children’s book: “I
Managed to Overcome my Fears”
C. Lima
ForAll, Desenvolvimento Pessoal e Bem-Estar, Unipessoal, Lda.,
Psicologia, Porto, Portugal
The book “I Managed to Overcome my Fears” was written based
on the experience of the author. The sleep disorders in children
are sometimes emotional fragility of reflection lived at the time.
Caused by routine changes or adaptive and considered normal in
child development. This book is meant to be a major therapeutic
instrument to be used by therapists and other technicians engaged
in the mental health of children. It contains the story, therapeu-
tic indications and therapeutic homework. Getting help children
overcome the fears that torment sleep, it will be easier with this
feature.
Disclosure of interest The author has not supplied his/her decla-
ration of competing interest.
EV1316
The effect of relaxation techniques
and trigger points therapy on stress
reduction of patients with mental
health disorders in a Greek hospital
G. Lyrakos ∗, D. Menti (MSc in Health Psychology) ,
I. Spyropoulos , V. Spinaris
1 General Hospital Nikaia “Ag. Panteleimon”, Psychiatric, Nikaia,
Greece
2 City Unity College, Department of Psychology, Athens, Greece
∗ Corresponding author.
Background Patients with mental health disorders usually suffer
from high stress levels. Trigger points therapy has been shown to
be very effective in providing prompt relief from stress in these
patients.
Aim To investigate the effect of the combined use of relaxation
techniques and trigger points therapy on stress levels of patients
with mental health disorders.
Method Thirty-one patients participated in this study, 14 (45.2%)
males and 17 (54.8%) females, with a mean age of 39. Out of them,
10 (32.3%) suffered fromanxiety disorders, 6 (19.4%) fromobsessive
compulsive disorder, 10 (32.3%) fromdepression and 5 (16.1%) from
chronic condition stress. Data analysis was conducted with t-test
analysis and ANOVA, using the SPSS software.
Results The findings revealed significant differences on stress
levels before and after the use of relaxation techniques and trig-
ger points therapy as t(30) = 18.316, P < 0.0001. Before the use
of relaxation techniques and trigger points therapy, individuals
reported higher stress levels (M= 6.129, SD = 1.087) compared to
after the therapy (M= 1.741, SD = .889). Moreover, significant dif-
ferences were found in stress reduction with regard to psychiatric
illnesses (F(3,27) = 5.027, P = 0.007). More specifically, individuals
with depression reported lower reductions in their stress levels
after the therapy compared to both those with chronic condi-
tion stress (M= –2.1, SD = 0.61, P = 0.013) and anxiety disorders
(M= –1.4, SD = 0.503, P = 0.05).
Conclusion The findings of this study highlight the importance of
using trigger points therapy, combined with relaxation techniques,
to reduce stress levels of patients with mental health disorders.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1317
Antipsychotic combination strategies
in patients with bipolar disorder
R. Molina Ruiz ∗, M. de Castro Oller , V. Gomez Macías ,
M. Roncero Rodriguez , F. Monta˜nes Rada
Hospital Universitario Fundación Alcorcón, Psychiatry, Madrid, Spain
∗ Corresponding author.
Introduction Treatment strategies in bipolar disorder (BPD) has
changed in the last decades and polypharmacy including antipsy-
chotics has become extremely common compared to monotherapy
with mood stabilisers. Clinicians tend to use 2 or more atypical
antipsychotics despite the lack of evidence to support safety, toler-
ability and efficacy of this practice.
Objective To determine most frequently used treatment strate-
gies in a sample of bipolar disorder patients and review of the
literature.
Methodology Analysis of a sample of 35 patients with BPD from
Madrid and review of recent literature for evidence arising from
international guidelines recommendations and meta-analyses.
Results Most frequently used treatment approach in our sample
was polytherapy, including at least 1 atypical antipsychotic (31%)
and polytherapy, including at least 2 antipsychotics (47%) together
with mood stabilisers. Only 11% were in monotherapy with mood
stabilisers and another 11%were in monotherapy with one atyp-
ical antipsychotic but without mood stabilisers. Aripiprazol and
olanzapinewere among themost preferred atypical antipsychotics.
Efficacy and safety of such combinations have not been systemati-
cally compared with monotherapy in the literature. Previous data
indicate that polytherapy in BPD may incur in important disadvan-
tages [1].
Conclusions Treatment of BPD remains challenging. Polytherapy
seem to have replaced monotherapy due to less relapses and better
results in treatment of affective symptoms. However, compliance
and secondary long-term effects should be taken into account.
Superiority in terms of efficacy in polytherapy needs to be balanced
with tolerability issues.More studies on combination therapy, long-
term efficacy and safety are needed.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.