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S624

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

conservative use of opioid analgesics. Importance of evaluation and

treatment of any underlying mood and/or anxiety syndromes was

stressed as well as liaison with other professionals (e.g. psycholo-

gists, neurologists, orthopaedics, and physiotherapists).

Conclusions

Patients with EUPD often report chronic pain, which

can only be managed by close collaboration of professionals from

different disciplines.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1843

EV859

Duloxetine added to tramadol in

chronic pain syndrome

M. Domijan

1 ,

, Z. Lonˇcar

1

, S. Udoviˇci´c

2

1

“Sestre milosrdnice” University Hospital Center- Clinic for

Traumatology, Department of Anaesthesiology, Reanimatology and

Intensive Care, Zagreb, Croatia

2

“Rebro” University Hospital Center- Psychiatric Clinic, Center for

Crisis Intervention, Zagreb, Croatia

Corresponding author.

Introduction

About 15–20% of the population suffering from the

chronic pain. Over time, chronic pain can result in different emo-

tional problems, social isolation, sleep disturbances, which reduce

the quality of life. Chronic pain syndrome (CPS) indicates persistent

pain, subjective symptoms in excess of objective findings, associ-

ated dysfunctional pain behavious and self-limitation in activities

of daily living. Duloxetine is a potent antidepressant approved by

the Food and Drug Administration for the chronic musculoskele-

tal disorder, diabetic neuropathic pain, fibromyalgia, generallized

anxiety disorder and major depressive disorder.

Objective

To determine the effect of duloxetine on the reduction

of pain and psychosocial suffering.

Aims

The goal of the treatment should be to effectively reduce

painwhile improving function and reducing psychosocial suffering.

Methods

Thirty-six adult, nondepressed patients, already on tra-

madol therapy were included. Patients with VAS (visual analogue

scale)

4were treated with duloxetine for 13weeks. We mea-

sured pain intensitywith theMcGill PainQuestionnaire-Short Form

(MPQ-SF) and compared VAS before starting the treatment with

duloxetine and weekly for 13weeks.

Results

Pain response was defined as a 30%decrease in the MPQ-

SF. A total of 62.5% of the sample met these criteria for response.

Among them, 13.8% of patients were discontinued because of

adverse effects. Duloxetine significantly improved functioning and

the quality of life in patients with CPS.

Conclusions

Because of it is analgesic properties, duloxetine in

the lower antidepressant doses (60mg taken ones daily) combined

with tramadol (another analgesic agent) can be useful in CPS for

patients who do not respond satisfactory to monotherapy.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1844

EV860

Prevalence of different pain

categories based on pain spreading in

older adults in Sweden: A multilevel

association with socio-demographic

characteristics, comorbidities and

drug consumption (Pain S65+)

E. Dragioti

, B. Larsson , L. Bernfort , L.Å. Levin , B. Gerdle

Linköping University, Department of Medical and Health Sciences,

Linköping, Sweden

Corresponding author.

Introduction

Understanding of factors related to chronic pain in

elderly is limited.

Objectives and aims

To estimate the prevalence of pain categories

based on spreading of pain on the body and to investigate how

such spreading is related to demographic variables, pain intensity,

comorbidities and medication in an elderly general population in

southeastern Sweden.

Methods

A total of 6611 adults aged

65 years participated

(mean age = 76.2; SD = 7.4). Pain categories were assessed by a self-

reported postal questionnaire covering 45 anatomical predefined

pain regions along with demographics, pain intensity during previ-

ous seven days, comorbidities and medication. Poisson regression

models with robust error variance were used for data analyzing.

Results

The prevalence of pain spreading categories was: chronic

local pain (CLP) 16%; chronic regional pain medium (CRP-Medium)

17%; chronic regional pain heavy (CRP-Heavy) 5% and chronic

widespread pain (CWSP) 2%. Overall, increased prevalence for

CRP-Heavy and CWSP in subjects 75–79 years old compared to

those 65–69, 70–74, 80–84 and

85 years were revealed. In men,

75–79 years old, CRP-Heavy was more common than in the other

pain categories. In women, 75–79 years old CWSP, was more

common than in the other pain categories. Pain intensity was

strongly associated with all pain categories (

P

< 0.001). CLP was

associated with trauma, rheumatoid arthritis, cancer, prescribed

and non-prescribed analgesics. CRP-Medium was associated with

rheumatoid arthritis, CRP-Heavy with rheumatoid arthritis and

lung diseases and CWSP with rheumatoid arthritis and prescribed

analgesics (

P

< 0.001).

Conclusions

Our findings elucidate heterogeneity of pain in

elderly which has to be further investigated.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1845

EV861

Distinct subgroups derived by cluster

analysis based on pain characteristics

and anxiety-depression symptoms in

Swedish older adults with chronic

pain (PainS65+)

E. Dragioti

, B. Gerdle , B. Larsson , L. Bernfort , L.Å. Levin

Linköping university, department of medical and health sciences,

Linköping university, Sweden

Corresponding author.

Introduction

There is a lack of research on subtypes of chronic

pain (CP) characteristics in the elderly.

Objective

To scrutinize major subgroups based on pain aspects

and psychological factors on an elderly population.

Aims

To determine possible differences between the derived

subgroups with respect to pain aspects and anxiety-depression

symptoms, health aspects and health care costs.

Methods

A cross-sectional study was implemented. A large

sample of 2300 individuals (M= 75.9 years, SD = 7.4) partici-

pated. Self-reported postal measurements regarding pain intensity,

spreading of pain, anxiety and depression (General well-being

schedule [GWBS]), and pain catastrophizing [PCS]) were used as

classification variables. A two-step cluster analysis was employed.

We further investigated whether the derived subgroups expe-

rienced different quality of life and general health. Calculations

regarding health care costs were also performed.

Results

Two major subgroups were identified: one low symp-

tom severity subgroup (Cluster 1;

n

= 1326; 58%) and one high

symptom severity subgroup (Cluster 2;

n

= 974; 42%). There were

statistical significant differences on pain intensity, spreading of

pain, anxiety, depression and pain catastrophizing between the two

subgroups (

P

< 0.001). Significant lower levels for quality of life and

general health (

P

< 0.001)were found for the high symptomseverity