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S626

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

significantly more numerous metaphorical and affective descrip-

tors (Pervichko, Zinchenko, 2013).

Conclusions

Received results prove an important role of psycho-

logical factors in etiology of chest pain in CADpatientswith the high

level of trait anxiety and alexithymia, which supports the urgency

of psychotherapy for them.

References not available.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1849

EV865

The analgesic efficacy of

ketamine-magnesium combination is

influenced by the order of medication

administration

K. Savic Vujovic

1 ,

, S. Vuckovic

1

, A. Vujovic

2

, M. Prostran

1

1

Medical faculty, department of pharmacology, clinical

pharmacology and toxicology, faculty of medicine, university of

Belgrade, Belgrade, Serbia

2

Medical faculty, university of Belgrade, hospital for ENT- KBC

Dragiˇsa Miˇsovi´c, Belgrade, Serbia

Corresponding author.

Introduction

Magnesium is an endogenous voltage-dependent

NMDA receptor channel blocker and ketamine is a non-competitive

NMDA receptor antagonist. Magnesiummay potentiate the effect of

ketamine in analgesia and anaesthesia, but may also interact in an

opposing manner. This study aimed at evaluating type of the inter-

action between magnesium sulphate and ketamine administered

systemically in rats with an acute nociceptive pain (tail-immersion

test).

Materials and methods

Analgesic activity was assessed by tail-

immersion test in male Wistar rats (200-250 g). The distal 5 cm of

the tail was immersed in a warm water bath (55

±

0.5

C) and the

time for tail-withdrawal was measured as response latency.

Results

Magnesium sulphate (2.5–30mg/kg, s.c.) and ketamine

(2.5-30mg/kg, i.p.) administered alone did not produce any effect.

However, significant antinociception (synergistic interaction) was

revealed at the following doses of ketamine: magnesium sulphate

of 5:5mg/kg, 2.5:5mg/kg and 10:5mg/kg. The effect was not dose-

dependent, and a greater response was obtained when ketamine

was administered before magnesium sulphate.

Conclusions

This study revealed that (1)magnesiumsulphate and

ketamine given alone were not effective against acute nociceptive

pain in rats, but (2) a combination of both drugs resulted in syner-

gistically inhibited nociception, (3) which occurred only at selected

low doses and proportions of the medications in a combination and

(4) suggested the importance of the order of drug administration.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1850

EV866

Labor pain management: Effect of

pelvic tilt by birth ball, sacrum-

perinea heat therapy, and combined

use of them, a randomized controlled

trial

S. Taavoni

1 ,

, S. Abdolahian

2

, L. Neisani

2

, H. Hamid

3

1

Iran university of medical sciences IUMS, Tehran university of

medical sciences TUMS, research institute for islamic &

complementary medicine RICM-IUMS, faculty of medicine TUMS,

Tehran, Iran

2

Iran university of medical sciences IUMS, nursing and midwifery

faculty, Tehran, Iran

3

Iran university of medical sciences IUMS, managment faculty,

Tehran, Iran

Corresponding author.

There are various safe non-pharmacologic methods for labor pain

management, which mostly decrees suffering of mother and some

of them significantly decrease pain too.

Aim

To assess effect of pelvic tilt by birth ball, sacrum-perinea

heat therapy and combination use of them on active phase of phys-

iologic labor.

Method

In this randomized control trial, 120 primiparous vol-

unteer with age 18-35 years, gestational age of 38–40 weeks, in

one of hospitals of Iran university of medical sciences were ran-

domly selected and divided in four groups: Pelvic tilt by using birth

ball, sacrum perinea heat therapy, combined use of two mentioned

methods and control group. Tools had 3 main parts of personal

characteristic, client examination form and pain visual analogue

scale (VAS). All ethical points were considered.

Results

Equality of four groups had been checked before inter-

vention. Lowest pain score first belong to pelvic tilt by birth ball

then combined group and finally in heat therapy, which all were

significantly less than control group. Significant decrease of pain

had been seen in birth ball group and combined group during after

30minutes intervention, but in the heat therapy group, it was seen

after 60minutes intervention (

P

-value < 0.05).

Conclusion

All three interventions of this study had significant

effect and decreased labor pain during active phase, but highest

decrease was in pelvic tilt by birth ball group and its effect started

after 30minutes intervention. It is suggested that that Obstetrics

and Midwives consider these safe methods for labor pain manage-

ment.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1851

EV867

Chronic pain and alcoholism – A

descriptive analysis of alcohol

dependent inpatients

T. Van der Kleij

, R. Lawrence

Royal Edinburgh hospital, psychiatry, Edinburgh, United Kingdom

Corresponding author.

Introduction

The co-existence of chronic pain and alcohol depen-

dence has been demonstrated in the literature. This population has

high rates of injury, and chronic pain may be a direct result of

conditions such as pancreatitis and neuropathy. Management may

be complicated by pharmacological and behavioural challenges,

potentially leaving patients with suboptimal treatment.

Aims

The aims of this survey were to: establish the prevalence of

chronic painwithin the study population, evaluate themultidimen-

sional impact it had on their lives, and quantify levels of satisfaction

with current treatment.

Methods

Over a 2-month period, 30 consecutive patients within

the Ritson Clinic with Alcohol Dependence Syndrome were

recruited. Using a modified version of the Brief Pain Inventory, each

patient was interviewed by a member of the study group.

Results

The frequency of chronic pain within this population was

47% (14/30) of which the majority was due to back pain (57%

[8/14]), followed by pain of the feet and hands (43% [6/14]). We

found that 64% (9/14) of patients were receiving treatment, and

the average levels of satisfaction (% relief of pain) within this group

was 57%.

Conclusions

Chronic pain and alcohol dependence are multifac-

torial and interlinked, with our analysis showing higher frequencies

of chronic pain compared to the general population. We hypoth-

esize that treating pain may lead to better outcomes as regards

abstinence from alcohol as well as improved quality of life. Larger