European Psychiatry - Volume 33 - March 2016

630 / 812

S626 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805
significantly more numerous metaphorical and affective descrip-
tors (Pervichko, Zinchenko, 2013).
Conclusions Received results prove an important role of psycho-
logical factors in etiology of chest pain in CADpatientswith the high
level of trait anxiety and alexithymia, which supports the urgency
of psychotherapy for them.
References not available.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV865
The analgesic efficacy of
ketamine-magnesium combination is
influenced by the order of medication
administration
K. Savic Vujovic ∗, S. Vuckovic , A. Vujovic , M. Prostran
1 Medical faculty, department of pharmacology, clinical
pharmacology and toxicology, faculty of medicine, university of
Belgrade, Belgrade, Serbia
2 Medical faculty, university of Belgrade, hospital for ENT- KBC
Dragiˇsa Miˇsovi´c, Belgrade, Serbia
∗ Corresponding author.
Introduction Magnesium is an endogenous voltage-dependent
NMDA receptor channel blocker and ketamine is a non-competitive
NMDA receptor antagonist. Magnesiummay potentiate the effect of
ketamine in analgesia and anaesthesia, but may also interact in an
opposing manner. This study aimed at evaluating type of the inter-
action between magnesium sulphate and ketamine administered
systemically in rats with an acute nociceptive pain (tail-immersion
test).
Materials and methods Analgesic activity was assessed by tail-
immersion test in male Wistar rats (200-250 g). The distal 5 cm of
the tail was immersed in a warm water bath (55 ± 0.5 ◦C) and the
time for tail-withdrawal was measured as response latency.
Results Magnesium sulphate (2.5–30mg/kg, s.c.) and ketamine
(2.5-30mg/kg, i.p.) administered alone did not produce any effect.
However, significant antinociception (synergistic interaction) was
revealed at the following doses of ketamine: magnesium sulphate
of 5:5mg/kg, 2.5:5mg/kg and 10:5mg/kg. The effect was not dose-
dependent, and a greater response was obtained when ketamine
was administered before magnesium sulphate.
Conclusions This study revealed that (1)magnesiumsulphate and
ketamine given alone were not effective against acute nociceptive
pain in rats, but (2) a combination of both drugs resulted in syner-
gistically inhibited nociception, (3) which occurred only at selected
low doses and proportions of the medications in a combination and
(4) suggested the importance of the order of drug administration.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV866
Labor pain management: Effect of
pelvic tilt by birth ball, sacrum-
perinea heat therapy, and combined
use of them, a randomized controlled
trial
S. Taavoni ∗, S. Abdolahian , L. Neisani , H. Hamid
1 Iran university of medical sciences IUMS, Tehran university of
medical sciences TUMS, research institute for islamic &
complementary medicine RICM-IUMS, faculty of medicine TUMS,
Tehran, Iran
2 Iran university of medical sciences IUMS, nursing and midwifery
faculty, Tehran, Iran
3 Iran university of medical sciences IUMS, managment faculty,
Tehran, Iran
∗ Corresponding author.
There are various safe non-pharmacologic methods for labor pain
management, which mostly decrees suffering of mother and some
of them significantly decrease pain too.
Aim To assess effect of pelvic tilt by birth ball, sacrum-perinea
heat therapy and combination use of them on active phase of phys-
iologic labor.
Method In this randomized control trial, 120 primiparous vol-
unteer with age 18-35 years, gestational age of 38–40 weeks, in
one of hospitals of Iran university of medical sciences were ran-
domly selected and divided in four groups: Pelvic tilt by using birth
ball, sacrum perinea heat therapy, combined use of two mentioned
methods and control group. Tools had 3 main parts of personal
characteristic, client examination form and pain visual analogue
scale (VAS). All ethical points were considered.
Results Equality of four groups had been checked before inter-
vention. Lowest pain score first belong to pelvic tilt by birth ball
then combined group and finally in heat therapy, which all were
significantly less than control group. Significant decrease of pain
had been seen in birth ball group and combined group during after
30minutes intervention, but in the heat therapy group, it was seen
after 60minutes intervention (P-value < 0.05).
Conclusion All three interventions of this study had significant
effect and decreased labor pain during active phase, but highest
decrease was in pelvic tilt by birth ball group and its effect started
after 30minutes intervention. It is suggested that that Obstetrics
and Midwives consider these safe methods for labor pain manage-
ment.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV867
Chronic pain and alcoholism – A
descriptive analysis of alcohol
dependent inpatients
T. Van der Kleij∗, R. Lawrence
Royal Edinburgh hospital, psychiatry, Edinburgh, United Kingdom
∗ Corresponding author.
Introduction The co-existence of chronic pain and alcohol depen-
dence has been demonstrated in the literature. This population has
high rates of injury, and chronic pain may be a direct result of
conditions such as pancreatitis and neuropathy. Management may
be complicated by pharmacological and behavioural challenges,
potentially leaving patients with suboptimal treatment.
Aims The aims of this survey were to: establish the prevalence of
chronic painwithin the study population, evaluate themultidimen-
sional impact it had on their lives, and quantify levels of satisfaction
with current treatment.
Methods Over a 2-month period, 30 consecutive patients within
the Ritson Clinic with Alcohol Dependence Syndrome were
recruited. Using a modified version of the Brief Pain Inventory, each
patient was interviewed by a member of the study group.
Results The frequency of chronic pain within this population was
47% (14/30) of which the majority was due to back pain (57%
[8/14]), followed by pain of the feet and hands (43% [6/14]). We
found that 64% (9/14) of patients were receiving treatment, and
the average levels of satisfaction (% relief of pain) within this group
was 57%.
Conclusions Chronic pain and alcohol dependence are multifac-
torial and interlinked, with our analysis showing higher frequencies
of chronic pain compared to the general population. We hypoth-
esize that treating pain may lead to better outcomes as regards
abstinence from alcohol as well as improved quality of life. Larger