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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

S623

memantine presents as good therapeutic option, showing improve-

ment in several cognitive domains. Metilphenidate steel needs

investigation but the evidence is that has positive impact in the

improvement of fatigue and concentration. There are lack of studies

using Gingko Biloba, but reveals high toxicity inducing gastroin-

testinal symptoms and risk of intracranial haemorrhage.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1840

EV856

The sedation could consist in a

therapeutic strategy in advanced

cancer conditions

A. Tamarindo

1

, C. Vogel

2

, G. Hida

3

, D. Malheiros

3

, J. Ropero

4

,

S. Taniguchi

1 ,

1

Albert Einstein Hospital, Basic Sciences, Brazil

2

Albert Einstein Hospital, Oncology, Brazil

3

Albert Einstein Hospital, Health Economics, Brazil

4

University Federal of ABC, Department of Mathematics

Computation and Cognition, Brazil

Corresponding author.

Introduction

The sedation could consist in a therapeutic strategy

in advanced cancer conditions.

Objective

To study the drugs administered to patients under Pal-

liative Care Sedation (PCS) audits effects on vital signs.

Methods

Our retrospective study included 101 oncological

patients with mean age of 66.5

±

13.4 years old and mean weight

of 48.5

±

3.36 kg, under PCS. The data were analysed applying the

test of Wilcoxon.

Results

The drugs administered to these patients under

PCS were morphine 55mg/kg/day associated to midazo-

lam 52.5mg/kg/day (Morph/Midazo) or the association of

morphine 55mg/kg/day, midazolam 52.5mg/kg/day and neu-

roleptics such as chlorpromazine 54.5mg/kg/day or haloperidol

13.25mg/kg/day (Morph/Midazo/Neurol). The values of vital

signs of these patients when the sedation was initiated were:

systolic blood pressure 116.55

±

16.98mmHg, diastolic bloodpres-

sure73.17

±

10.55mmHg, heart rate 83.41

±

16.25bpm, respiratory

rate 19.39

±

3.97 rpm and body temperature 35.91

±

0.57

C. No

significant differences between these groups were observed.

Vital signs measures were collected 48 hours before the patient’s

death. Significant reduction in systolic blood pressure 77.5mmHg,

diastolic blood pressure 43.3mmHg were observed in the group

(Morph/Benzo/Neurol). The Wilcoxon test for independent sam-

ples to a significance level of 5% we obtain a

P

-value of 0.01. The

sedation period was 2.56

±

0.23 days.

Conclusion

Neuroleptic, a central nervous system (CNS) depres-

sant drug, when associated to other two depressants (mor-

phine/midazolam), conducted to the patient’s vital signs reduction.

Considering the short period of time between the beginning of

sedation and the patients’ death; and that palliative sedation should

not include the hastening of patients’ death, we suggest a better

drug association criteria.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1841

EV857

Symptom burden in cancer patients

and caregiving experience

J. Teixeira Silva

, M. Gonc¸ alves , Z. Santos

Centro Hospitalar e Universitário de Coimbra, Psychiatry, Coimbra,

Portugal

Corresponding author.

Introduction

Cancer patients typically experience multiple phys-

ical and psychological symptoms that may result from the disease

or from treatment. Themost common are pain, depression, anxiety,

fatigue, insomnia, breathlessness, nausea, constipation, diarrhea

and anorexia. The high symptom burden profoundly affects the

patient but also the caregiver, which frequently experiences anxi-

ety and depression.

Objectives

Identify a correlation between patient symptoms and

caregiver emotional disturbances.

Aims

The aim of the present study was to improve the iden-

tification of vulnerable family caregivers who could require

psychotherapeutic and psychopharmacological support.

Methods

For this purpose, all eligible patients and caregivers

were approached during a regularly scheduled patient clinic visit

at a Portuguese psycho-oncology unit. Data was collected using the

Memorial Symptom Assessment Scale-Short Form and Depression

Anxiety Stress Scale-21. Sociodemographic and clinical data were

also collected. Statistics were performed with SPSS.

Results

High levels of psychopathology in caregivers were asso-

ciated with female caregiver sex and worse patient physical and

emotional well-being. Uncontrolled pain was related with high

scores in DASS-21.

Conclusions

Cancer patient’s caregivers experienced high levels

of anxiety and depression associated with worse patient well-

being. The psychological stress of caregiving has a negative impact

not only on the health of the caregivers but also on cancer patients.

Early interventions directed at patient symptoms and caregiver

support may improve quality of life in this population.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1842

Pain and treatment options

EV858

Pain management in context of

emotionally unstable personality

disorder

E. Dobrzynska

1 ,

, N. Clementi

2

1

Cygnet Health Care, Cygnet Hospital Kewstoke,

Weston-super-Mare, United Kingdom

2

NHS Grampian, Royal Cornhill Hospital, Aberdeen, United Kingdom

Corresponding author.

Introduction

Emotionally unstable personality disorder (EUPD) is

characterised by Pain Paradox. The response for acute, self-induced

pain seems to be attenuatedwhile chronic, endogenous pain is usu-

ally intolerable. Pain management of this group of patients poses

many difficulties, including discrepancies between subjective and

objective pain assessment, patients’ demands for strong analgesics

and impact on relationship with other professionals.

Objectives and aims

The purpose of the study was to review pain

management options for persons diagnosed with EUPD and com-

plaining of chronic pain.

Methods

MEDLINE and PsycINFO databases were searched for all

English-language articles containing the keywords “chronic pain”,

“pain management”, “borderline personality disorder”, and “emo-

tionally unstable personality disorder”.

Results

Seventeen relevant papers were identified. Suggested

first step in pain management was ongoing clarification with EUPD

patients that analgesics are unlikely to fully treat their pain and

support of non-pharmacological approaches to pain, including

cognitive-behavioural strategies. Regarding pharmacology, liberal

use of non-addicting analgesics was recommended with highly