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S622

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

Introduction

For the most part, central nervous system (CNS)

tumors present themselves with focal neurologic sing or manifes-

tations resulting from increased intracranial pressure. However, in

particular cases, these tumors may present exclusively psychiatric

symptoms.

Objective

This communication explores importance of CNS

tumors as differential diagnosis of various psychiatric disorders.

Aims

Highlight the need of acknowledging this important differ-

ential diagnosis (CNS tumors) in current psychiatry practice, while

presenting a clinical case as an example of the subject.

Methods

It is exposed a bibliographic review of the topic, fol-

lowed by the description of a clinical case regarding a patient

with pituitary adenoma and simultaneous installation of psychotic

symptoms namely delusional paranoid ideation.

Results

The authors present a case report of a 66-year-old

patient admitted compulsively in a Psychiatric ward in the con-

text of behavioral changes associated with delusional ideation of

paranoid content. Multidisciplinary assessed by specialties of Psy-

chiatry, Neurology, Neurosurgery, Endocrinology and Psychology,

concluded by the presence of nonfunctioning pituitary adenoma

associated with cognitive major disturbance.

Conclusions

The tumors of the CNS can be associated with a

whole variety of psychiatric symptoms such as psychosis, anxi-

ety, depression or cognitive impairment, even in the absence of

organic/neurological symptoms. Its role in the genesis of psy-

chiatric symptomatology makes these neoplasias an important

differential diagnosis, whose clinical approach should include dif-

ferent medical specialties integrated as a multidisciplinary team.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1837

EV853

Pancreatic cancer associated with

psychotic depression – A case report

M.E. Perfene-Banu

, A.M

. Cristache , I.A. Andrei , M.C. Tudorache ,

R.E. Popa , M. Manea

Psychiatry Clinical Hospital “Prof. Dr. Alexandru Obregia”, IV,

Bucuresti, Romania

Corresponding author.

Pancreatic cancer is an aggressive form of cancer with increasing

incidence and a 5-year survival rate of 4% for all stages. Depression

and anxiety have a higher prevalence than the general popula-

tion in all cancer types. Also, rates of depression in patients with

pancreatic cancer are higher than in patients with other types of

gastrointestinal neoplasms. Depression in pancreatic cancer has

also been shown to impair quality of life, so early and adequate

antidepressant treatment is an essential component of comprehen-

sive supportive care.

We would like to report the case of a 67-year-old female patient,

with no previous psychiatric history, brought to the psychia-

try emergency unit by her husband for psycho-motor agitation,

persecutory delusions, delusional jealousy and bizarre behavior.

According to her husband, the symptoms started insidiously over

the last few weeks and that she attempted suicide by drug over-

dose three days before admission to our clinic, which she denies.

Three years prior to her hospitalization the patient received sur-

gical, radiotherapy and chemotherapy treatment for a base of

tongue tumor and 6months prior to her psychiatric admission, the

was diagnosed with cephalic pancreatic neoplasm for which she

received seven cycles of chemotherapy. Treatment with mirtaza-

pine, risperidone, and lorazepam was initiated. The evolution was

favorable and the patient was discharged one week later.

Early recognition and treatment of mood disorders associated with

cancer are important because, left untreated, theymay lead to diffi-

culty inmanaging symptoms, increased demand for health services

and low adherence to treatment.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1838

EV854

Characterization of a referral to

psycho-oncology liaison consults in a

general hospital

J. Ramos

, A. O

liveira

Centro Hospitalar Tondela-Viseu, Psychiatry, Viseu, Portugal

Corresponding author.

Introduction

Liaison psychiatry is based on a practice that lies

on the interface between psychological, sociological and biological

factors of illness. Cancer is a devastating disease. For many patients

the occurrence of it is synonymous of chronic, severe or lethal

outcome. It is important for health professionals to be aware of

the psychological suffering of these patients and promote a proper

use of specialized consultations in order to increase and improve

adherence to treatment.

Aims

To make known the reality of referral to a Psycho-Oncology

Liaison consult and its context in literature.

Methods

Data collection on applications for the 1st request to

Psycho-Oncology liaison consults occurred between 2010–2012

in the variables, gender, age, reason for referral, psychiatric his-

tory, cancer diagnosis, knowledge of the referral and who does

(patient/family/service) and psychiatric diagnosis. Statistical anal-

ysis with Microsoft Excel 2010

®

.

Results

It was found that there were 83 applications during the

three years, 24 men and 59 women. The most prevalent cancer

diagnoses were breast cancer (29.89%) and colorectal carcinoma

(19.28%). Most patients had knowledge of the request (75.9%). The

reason was mostly for Anxiety and Depression (33.73%).

Conclusion

Cancer disease coupled with feelings of loss of auton-

omy, hopelessness and pain can lead the patient to develop

psychopathology of anxious-depressive disorders. This condition

may hamper the normal recovery of the patient. The promotion

of mental well-being in cancer patients is critical to recovery and

leads to a better adherence to treatment, inclusive can influence

survival.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1839

EV855

Cognitive decline induced by cerebral

radiotherapy: What to do?

T. Silva

, T. Carvalhão , M. Fernandes , J. Silva

Hospitalar and Universitary Center of Coimbra, Psychiatry, Coimbra,

Portugal

Corresponding author.

Introduction

Each year about 200 000 individuals undergo radio-

therapy treatment to primary brain cancer or brain metastasis. The

number of survivor has been rising with the improvement of treat-

ment and techniques. The current evidence suggest a progressive

cognitive decline in the years following brain irradiation, and show

that 50% of the people that survive longer than 6months are most

affected.

Aim

The authors propose to make a literature review, trying to

expose the cognitive decline profile after cerebral brain therapy and

how to choose the best therapeutic option.

Methodology

Literature review using the data base available in

the Documentation Service of the Central Library of the Centro

Hospitalar e Universitário de Coimbra.

Results and conclusions

The severity profile of cognitive decline

influences the therapeutic options. The use of donepezile and