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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

S485

cluster analysis showed between T0 and T2 a meaningful and sig-

nificant rise of global health clusters “General health perceptions”

(

P

< 0.05), “Change in overall health status” (

P

< 0.001) and a signif-

icant impairment in cluster “Emotional role functioning” (

P

< 0.05).

Conclusions

Our real world data are consistent with trial setting

results [Younoussi, 2014]. Contrary to previous IFN -based ther-

apy, new regimens don’t seem to be associated with psychiatric

side effects and suggest an immediate gain in general health PROs

over the treatment period.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1412

EV428

Incapacity to decide in liaison

psychiatry: Analysis of sample of

patients admitted in somatic

departments of a general hospital

M. Nascimento

1 ,

, F. Vicente

2

, C. Oliveira

2

, N. Silva

3

, C. Vieira

1

,

A. Luís

1

, T. Maia

1

1

Hospital Professor Dr. Fernando Fonseca- EPE, psychiatry, Amadora,

Portugal

2

Centro Hospitalar Psiquiátrico de Lisboa, psychiatry, Lisbon,

Portugal

3

Centro Hospitalar de Vila Nova de Gaia/Espinho, psychiatry, Vila

Nova de Gaia, Portugal

Corresponding author.

Introduction

Decision capacity (DC) is a complex construct,

whose assessment poses huge challenges to Liaison Psychiatrist

(LP).

Objectives/aims

Assess factors related to DC in patients with

somatic disorders admitted in medical and surgical departments

of a general hospital.

Methods

Clinical records of patients who were submitted to a DC

assessment at Hospital Fernando Fonseca (Portugal), from 1st Jan-

uary 2012 to 31st December 2014 were retrospectively analysed.

Collected data were statistically analysed with SPSS

®

. Univariable

analysis was performed, in order to determine factors related to

DC.

Results

Data from35 patients subject to DC evaluationwere con-

sidered, of whom 42.4% were considered unable to give consent

to medical and/or surgical procedures. Most of these assessments

were related to patients who refused treatment. Patients unable to

decide were predominantly male and mainly affected by organic

mental or neurocognitive disorders (

P

< 0.05). There were no sta-

tistical significant differences in the age of those considered able

or unable to decide. After PL intervention, 40% of those consid-

ered unable to decide changed their decision. However, it was not

significantly related to the ability to give consent.

Conclusions

Neurocognitive disorders are common diagnosis

found in patients admitted in somatic departments with no DC. Fre-

quent change in decision after LP intervention may reflect not only

cognitive fluctuations, but also a possible influence of LP interven-

tion on patients’ choices. Appropriate standardized measures are

useful tools in assessing patientswith cognitive impairment, reduc-

ing evaluation differences between professionals, and in order to

increase LP decisions credibility.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1413

EV429

Acute hypomania in systemic lupus

erythematosus, differential diagnosis.

A case report

D.K. Ochoa García

, G.M. Chauca Chauca , L. Carrión Expósito

Hospital Infanta Margarita, Unidad de Salud Mental Comunitaria

Cabra, Cabra-Córdoba, Spain

Corresponding author.

Introduction

It is well known that seizures and psychosis are

diagnostic criteria for systemic lupus erythematosus (SLE), how-

ever, there could be many other neuropsychiatric symptoms.

The American College of Rheumatology Nomenclature provides

case definitions for 19 neuropsychiatric syndromes seen in SLE

(NPSLE), including cognitive impairment, psychosis, mood and anx-

iety disorders. Lack of specificmanifestations difficult diagnosis and

treatment.

Objectives

To address the diagnostic difficulties that involve the

appearance of hypomanic symptoms in the course of SLE treated

with high doses of corticoids in a patient with a depressive episode

history.

Method

Description of case report and literature revision. We

report the case of a 22-year-old woman who presented irritable

mood, sexual disinhibition, insomnia and inflated self-esteem. The

patient was recently diagnosedwith SLE andwas on treatment with

50 mg/d prednisone. She had familiar history for bipolar disorder

and was taking 20 mg/d paroxetine since the last 6 months after

being diagnosed with major depressive episode.

Results

We proposed differential diagnosis between psychiatric

symptoms secondary to central nervous system SLE involvement,

a comorbid bipolar disorder or prednisone-induced mood symp-

toms. Fluctuation of hypomanic symptoms during hospitalization,

poor relationship with variation in corticosteroid doses, findings

on brain MRI compatible with vasculitis and positive antibodies,

oriented this case to a neuropsychiatric manifestation of LES.

Conclusions

We should keep inmind that symptoms of neuropsy-

chiatric SLE may vary from more established manifestations of

NPSLE to mild diffuses ones. More studies are needed to expand

knowledge in the relationship between mood disorders and neu-

ropsychiatric SLE.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1414

EV430

Risk factors for a new cardiac event

after a first acute coronary syndrome

P. Ossola

1 ,

, F. Scagnelli

1

, A. Longhi

1

, C. De Panfilis

1

, M. Tonna

2

,

C. Marchesi

1

1

University of Parma, Psychiatry Unit-Department of Neuroscience,

Parma, Italy

2

AUSL of Parma, Mental Health Department, Parma, Italy

Corresponding author.

Introduction

Depression is an established risk factor for acute

coronary syndrome (ACS), nonetheless themechanisms underlying

this association are still unclear and literature disagrees on the role

played by anxiety. Moreover, most of the studies included subjects

with a long lasting history of heart disease or recurrent depressive

episodes that could bias the results.

Objectives

We performed serial assessments of anxiety, depres-

sion and newcardiac events in a cohort of never-depressed patients

in the two years after their first ACS.