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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

S311

Aims

This study examines drug-naive youth in their first year of

treatment with SGAs, and the possible development of markers of

the metabolic syndrome, in a naturalistic setting. We also look at

aspects of the patient’s disease and environment that may predict

which patients are the most at risk for these metabolic derange-

ments.

Methods

Thirty-five drug-naive adolescents were recruited after

their contact with the Psychosis Team at Department of Child and

Adolescent Psychiatry in Odense, Denmark. Measurements were

taken at different times over the course of their first year of treat-

ment. Themarkers included, among others: bodymass index, waist

circumference, bloodpressure, fasting blood glucose, aswell as high

density, low density and total cholesterol. Factors of the patients’

lifestyle and development were recorded as well.

Results

The results will be presented at the EPA March 2016 in

Madrid.

Conclusions

This is, to our knowledge, the first study to include

all of the aforementioned aspects in drug-naive adolescents over a

12-month period. Because of this, it may provide us with a unique

insight into how, and in which patients, these metabolic changes

develop.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.673

EW556

Depression in the active phase of

paranoid schizophrenia in relation to

age of onset and sex

M. Skokou

, P. Gourzis

University Hospital of Patras, Psychiatry, Patras, Greece

Corresponding author.

Introduction

Depression is often observed in schizophrenia, in all

phases of the disorder. Age of illness onset and sex have been found

to correlate with depressive symptomatology in many but not all

studies.

Aims

In the present work the relation between depressive symp-

toms and age of onset and sex was investigated, in a sample of

patients with paranoid schizophrenia.

Methods

Eighty-eight (88) patients with paranoid schizophre-

nia according to DSM-IV-TR criteria were examined, 21 of which

became ill at

35 years of age (late onset), whereas 60 had age of

onset < 30 years (young onset). During the active phase the Calgary

Depression Scale for Schizophrenia (CDSS) was applied. Compar-

isons were performed by using the two-tailed Wilcoxon rank-sum

and Chi-squared tests.

Results

The percentage of patients with depression (CDSS > 6) in

the whole sample was 27.2%. There was a trend for higher scores in

early awakening in late onset patients (

P

= 0.060). In men, there

was a trend for heavier depression in late onset patients, and

higher scores in early awakening (

P

= 0.082, 0.019, respectively). In

young onset patients, there was a trend for heavier symptomato-

logy in women compared with men, and heavier pathological guilt

(

P

= 0.073, 0.007, respectively), whereas in late onset patients, there

was a trend for heavier self depreciation in men (

P

= 0.072).

Conclusions

Although the frequency of depression does not seem

to be influenced by age of onset or sex, more subtle differences are

found in the severity of certain depressive symptoms, in relation to

these factors, possibly warranting further investigation.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.674

EW557

Is there a cumulative effect of social

disadvantage on risk of psychosis?

S.A. Stilo

1 ,

, C. Gayer-Anderson

2

, S. Beards

2

, K. Hubbard

2

,

A. Onyejiaka

2

, F. Bourque

2

, V. Mondelli

3

, P. Dazzan

4

,

C. Pariante

3

, M. Di Forti

5

, R. Murray

4

, C. Morgan

2

1

Institute of Psychiatry-Psychology and Neuroscience-King’s College

London, Psychosis Studies and Health Services and Population

Research, London, United Kingdom

2

Institute of Psychiatry-Psychology and Neuroscience-King’s College

London, Health Services and Population Research, London, United

Kingdom

3

Institute of Psychiatry-Psychology and Neuroscience-King’s College

London, Psychological Medicine, London, United Kingdom

4

Institute of Psychiatry-Psychology and Neuroscience-King’s College

London, Psychosis Studies, London, United Kingdom

5

Institute of Psychiatry-Psychology and Neuroscience-King’s College

London, Social Genetic and Developmental Psychiatry, London,

United Kingdom

Corresponding author.

A growing body of evidence suggests that experiences of social

disadvantage are associated with an increased risk of psychosis.

However, only a few studies have specifically looked at cumulative

effects and long-term associations. We compared the prevalence of

specific markers of social disadvantage at, and prior to, first contact

with psychiatric services in patients suffering their first episode of

psychosis and in a control sample and explored long-term asso-

ciations, cumulative effects, and directions of associations. We

collected information from 332 patients and from 301 controls

recruited from the local population in South-East London. Three

indicators of social disadvantage in childhood and six indicators of

social disadvantage in adulthood were analysed. Compared with

controls, cases were approximately two times more likely to have

had a parent die before the age of 17 (OR 1.95, 95% CI 0.9–3.8) and

approximately three times more likely to have experienced a long-

term separation from one or both parents before the age of 17 (OR

3.04, 95% CI 2.1–4.3). Cases were also more likely than controls to

report two ormoremarkers of adult social disadvantage, not only at

first contact with psychiatric services (OR 9.5, 95% CI 5.4–16.7), but

also at onset (OR 8.5, 95% CI 4.8–15), one year pre-onset (OR 4.5, 95%

CI 2.8–7), and five years pre-onset (OR 2.9, 95% CI 1.8–4.6). Greater

numbers of indicators present and long-term exposure were asso-

ciated with progressively greater odds of psychosis. There is some

evidence that social disadvantage tends to cluster and accumulate.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.675

EW558

Glycine transporter inhibitor

sarcosine changes neuronal and glial

parameters in the left dorsolateral

prefrontal cortex and glutamatergic

parameters in the left hippocampus in

stable schizophrenia

D. Strzelecki

1 ,

, M. Podgórski

2

, O. Kału ˙zy ´nska

1

,

M. Kotlicka-Antczak

1

, O. Gawlik-Kotelnicka

1

, A. Gmitrowicz

3

,

L. Stefa ´nczyk

2

, P. Grzelak

2

1

Central Clinical Hospital, Department of Affective and Psychotic

Disorders–Medical University of Łód´z, Łód´z, Poland

2

University Hospital No.1, Department of Radiology–Diagnostic

Imaging–Medical University of Łód´z, Łód´z, Poland

3

Central Clinical Hospital, Department of Adolescent

Psychiatry–Medical University of Łód´z, Łód´z, Poland

Corresponding author.