European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348 S311
Aims This study examines drug-naive youth in their first year of
treatment with SGAs, and the possible development of markers of
the metabolic syndrome, in a naturalistic setting. We also look at
aspects of the patient’s disease and environment that may predict
which patients are the most at risk for these metabolic derange-
ments.
Methods Thirty-five drug-naive adolescents were recruited after
their contact with the Psychosis Team at Department of Child and
Adolescent Psychiatry in Odense, Denmark. Measurements were
taken at different times over the course of their first year of treat-
ment. Themarkers included, among others: bodymass index, waist
circumference, bloodpressure, fasting blood glucose, aswell as high
density, low density and total cholesterol. Factors of the patients’
lifestyle and development were recorded as well.
Results The results will be presented at the EPA March 2016 in
Madrid.
Conclusions This is, to our knowledge, the first study to include
all of the aforementioned aspects in drug-naive adolescents over a
12-month period. Because of this, it may provide us with a unique
insight into how, and in which patients, these metabolic changes
develop.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW556
Depression in the active phase of
paranoid schizophrenia in relation to
age of onset and sex
M. Skokou ∗, P. Gourzis
University Hospital of Patras, Psychiatry, Patras, Greece
∗ Corresponding author.
Introduction Depression is often observed in schizophrenia, in all
phases of the disorder. Age of illness onset and sex have been found
to correlate with depressive symptomatology in many but not all
studies.
Aims In the present work the relation between depressive symp-
toms and age of onset and sex was investigated, in a sample of
patients with paranoid schizophrenia.
Methods Eighty-eight (88) patients with paranoid schizophre-
nia according to DSM-IV-TR criteria were examined, 21 of which
became ill at ≥ 35 years of age (late onset), whereas 60 had age of
onset < 30 years (young onset). During the active phase the Calgary
Depression Scale for Schizophrenia (CDSS) was applied. Compar-
isons were performed by using the two-tailed Wilcoxon rank-sum
and Chi-squared tests.
Results The percentage of patients with depression (CDSS > 6) in
the whole sample was 27.2%. There was a trend for higher scores in
early awakening in late onset patients (P = 0.060). In men, there
was a trend for heavier depression in late onset patients, and
higher scores in early awakening (P= 0.082, 0.019, respectively). In
young onset patients, there was a trend for heavier symptomato-
logy in women compared with men, and heavier pathological guilt
(P = 0.073, 0.007, respectively), whereas in late onset patients, there
was a trend for heavier self depreciation in men (P = 0.072).
Conclusions Although the frequency of depression does not seem
to be influenced by age of onset or sex, more subtle differences are
found in the severity of certain depressive symptoms, in relation to
these factors, possibly warranting further investigation.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW557
Is there a cumulative effect of social
disadvantage on risk of psychosis?
S.A. Stilo ∗, C. Gayer-Anderson , S. Beards , K. Hubbard ,
A. Onyejiaka , F. Bourque , V. Mondelli , P. Dazzan ,
C. Pariante , M. Di Forti , R. Murray , C. Morgan
1 Institute of Psychiatry-Psychology and Neuroscience-King’s College
London, Psychosis Studies and Health Services and Population
Research, London, United Kingdom
2 Institute of Psychiatry-Psychology and Neuroscience-King’s College
London, Health Services and Population Research, London, United
Kingdom
3 Institute of Psychiatry-Psychology and Neuroscience-King’s College
London, Psychological Medicine, London, United Kingdom
4 Institute of Psychiatry-Psychology and Neuroscience-King’s College
London, Psychosis Studies, London, United Kingdom
5 Institute of Psychiatry-Psychology and Neuroscience-King’s College
London, Social Genetic and Developmental Psychiatry, London,
United Kingdom
∗ Corresponding author.
A growing body of evidence suggests that experiences of social
disadvantage are associated with an increased risk of psychosis.
However, only a few studies have specifically looked at cumulative
effects and long-term associations. We compared the prevalence of
specific markers of social disadvantage at, and prior to, first contact
with psychiatric services in patients suffering their first episode of
psychosis and in a control sample and explored long-term asso-
ciations, cumulative effects, and directions of associations. We
collected information from 332 patients and from 301 controls
recruited from the local population in South-East London. Three
indicators of social disadvantage in childhood and six indicators of
social disadvantage in adulthood were analysed. Compared with
controls, cases were approximately two times more likely to have
had a parent die before the age of 17 (OR 1.95, 95% CI 0.9–3.8) and
approximately three times more likely to have experienced a long-
term separation from one or both parents before the age of 17 (OR
3.04, 95% CI 2.1–4.3). Cases were also more likely than controls to
report two ormoremarkers of adult social disadvantage, not only at
first contact with psychiatric services (OR 9.5, 95% CI 5.4–16.7), but
also at onset (OR 8.5, 95% CI 4.8–15), one year pre-onset (OR 4.5, 95%
CI 2.8–7), and five years pre-onset (OR 2.9, 95% CI 1.8–4.6). Greater
numbers of indicators present and long-term exposure were asso-
ciated with progressively greater odds of psychosis. There is some
evidence that social disadvantage tends to cluster and accumulate.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW558
Glycine transporter inhibitor
sarcosine changes neuronal and glial
parameters in the left dorsolateral
prefrontal cortex and glutamatergic
parameters in the left hippocampus in
stable schizophrenia
D. Strzelecki ∗, M. Podgórski , O. Kału ˙zy ´nska ,
M. Kotlicka-Antczak , O. Gawlik-Kotelnicka , A. Gmitrowicz ,
L. Stefa ´nczyk , P. Grzelak
1 Central Clinical Hospital, Department of Affective and Psychotic
Disorders–Medical University of Łód´z, Łód´z, Poland
2 University Hospital No.1, Department of Radiology–Diagnostic
Imaging–Medical University of Łód´z, Łód´z, Poland
3 Central Clinical Hospital, Department of Adolescent
Psychiatry–Medical University of Łód´z, Łód´z, Poland
∗ Corresponding author.