

S310
24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348
presence/absence of cognitive impairment (considering a GCI z-
score of–1 as cut-off point). We performed a MANOVA to compare
the 4 groups’ functional outcome scores.
Results
Fig. 1 shows the significant differences between groups
regarding functional outcome.
Conclusions
The combination of negative symptoms and cog-
nitive impairment has deleterious effects over functionality, but
negative symptoms alone are related to functional outcome, inde-
pendently of cognitive impairment.
Fig. 1
Disclosure of interest
The authors have not supplied their decla-
ration of competing interest.
http://dx.doi.org/10.1016/j.eurpsy.2016.01.670EW553
Electroconvulsive therapy in
schizophrenia – where do we stand?
J. Silva
1 ,∗
, J. Mota
2, P. Azevedo
31
Custoias, Portugal
2
Hospital de Magalhaes Lemos, ECT Unit- C Service, Oporto, Portugal
3
Hospital de Magalhaes Lemos, C Service, Oporto, Portugal
∗
Corresponding author.
Introduction
Electroconvulsive therapy is currently used in the
management of severe depression, long-termmania and catatonia.
Regarding schizophrenia-related psychosis ECT is also an option,
but the indication is restrictive to severe cases, drug intolerance
or resistant ones. Lack of evidence of cost-effectiveness compared
to clozapine, and side effects of ECT techniques before 2003, influ-
enced NICE guidance to not recommend ECT in schizophrenia, but
modern ECT machines and procedures are subsequent to 2003. ECT
is often performedwhen clozapine fails to respond inmonotherapy
or if there is intolerance to antipsychotic side effects. ECT in combi-
nationwith clozapine seems to have significant results allowing the
patients to achieve rapid control of psychotic symptoms with fewer
side effects, comparing with antipsychotics-association strategies.
Objectives
To summarized the latest literature about this field
and to present recent data from the Electrovulsivetherapy Unit, in
Hospital de Magalhães Lemos, Portugal.
Aim
To explore and critically review the controversies of
electroconvulsive therapy in the management of drug-resistant
schizophrenia.
Methods
Retrospective data of an Electroconvulsive TherapyUnit
during 2006–2015 was review.
Results
198 ECT treatments in schizophrenic patients were per-
formed in our unit, during 2006–2007, in a total of 647 ECT (30,6%).
In 2014–2015, 945 schizophrenic patients received ECT treatment,
in a total of 2149 performed ECT (43,9%).
Conclusions
Although guidelines are crucial for the uniform
practice of medicine, sometimes is important to be critical about
them. The use of ECT in schizophrenia is safe and effective and
further research is needed to continue to support this treatment.
Disclosure of interest
The authors have not supplied their decla-
ration of competing interest.
http://dx.doi.org/10.1016/j.eurpsy.2016.01.671EW554
Symptoms of schizophrenia and
suicidal behaviour
M. Sisek- ˇSprem
∗
, M.Herceg , V. Juki´c
University Psychiatric Hospital Vrapˇce, Integral Ward, Zagreb,
Croatia
∗
Corresponding author.
Introduction
Risk prediction for suicide in schizophrenia is
known to be complex. Illness-related risk factors are important
predictors, with number of prior suicide attempts, depressive
symptoms, active hallucinations and delusions.
Aims
To analyze the impact of clinical features of schizophrenia
on suicidal behaviour and analyze relationship between violence
and suicidality.
Methods
We compared a group of 28 suicidal, 32 hetero-
aggressive and 60 non-aggressive male patients with schizophre-
nia. The severity of the psychopathologywas assessed using PANSS,
hetero-aggressiveness using OAS and suicidality using C-SSRS and
InterSePT scales.
Results
Suicidality is in positive correlation with the presence
of depression (
r
= 0.485,
P
< 0.001) and imperative hallucinations
(
r
= 0.391,
P
< 0.001) but in negative correlation with total PANSS
score (
r
= –0.297,
P
< 0.001), impulsiveness (
r
= –0,237,
P
< 0.001)
and hetero-aggressive behaviour (
r
= –0.551,
P
< 0.001). Previous
attempt was found in 53% suicidal patients (
P
= 0.047). Heteroag-
gressiveness is in positive correlation with total PANSS (
r
= 0.43,
P
< 0.001) and impulsive behaviour (
r
= 0.57,
P
< 0.001). This study
supports the contention that high impulsivity in schizophrenia
patients is significant in the etiology of violent but not suicidal
behaviour.
Conclusion
In the order to diminish the level of suicide among
patients with schizophrenia we must be aware of the importance
of depressive symptoms, imperative hallucinations and previous
attempts. This study supports the contention that high impulsivity
in schizophrenia patients is significant in the etiology of violence
but not suicidal behaviour.
Keywords
Schizophrenia; Suicidality; Clinical features
Disclosure of interest
The authors have not supplied their decla-
ration of competing interest.
http://dx.doi.org/10.1016/j.eurpsy.2016.01.672EW555
Second-generation antipsychotics and
the metabolic syndrome in drug-naive
adolescents
C. Sjo
∗
, N. Bilenberg
Research Unit for Child- and Adolescent Psychiatry Odense-
Psychiatric Hospital and University of Southern Denmark, Psychiatric
Hospital and University of Southern Denmark, Odense, Denmark
∗
Corresponding author.
Introduction
Poor physical health and shorter life expectancy
often follows from mental illness. If the disorder starts in child-
hood/adolescence, the risk of this outcome is even higher. Second
generation antipsychotics (SGAs) are suspected to increase cardio-
vascular risk factors through the development of the metabolic
syndrome.
Objective
We investigated all the aspects of the metabolic syn-
drome in drug-naive youth, over a period of 12months of treatment
with SGAs.