European Psychiatry - Volume 33

S310

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

presence/absence of cognitive impairment (considering a GCI z-

score of–1 as cut-off point). We performed a MANOVA to compare

the 4 groups’ functional outcome scores.

Results

Fig. 1 s

hows the significant differences between groups

regarding functional outcome.

Conclusions

The combination of negative symptoms and cog-

nitive impairment has deleterious effects over functionality, but

negative symptoms alone are related to functional outcome, inde-

pendently of cognitive impairment.

Fig. 1

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.670

EW553

Electroconvulsive therapy in

schizophrenia – where do we stand?

J. Silva

1 ,

∗

, J. Mota

, P. Azevedo

Custoias, Portugal

Hospital de Magalhaes Lemos, ECT Unit- C Service, Oporto, Portugal

Hospital de Magalhaes Lemos, C Service, Oporto, Portugal

∗

Corresponding author.

Introduction

Electroconvulsive therapy is currently used in the

management of severe depression, long-termmania and catatonia.

Regarding schizophrenia-related psychosis ECT is also an option,

but the indication is restrictive to severe cases, drug intolerance

or resistant ones. Lack of evidence of cost-effectiveness compared

to clozapine, and side effects of ECT techniques before 2003, influ-

enced NICE guidance to not recommend ECT in schizophrenia, but

modern ECT machines and procedures are subsequent to 2003. ECT

is often performedwhen clozapine fails to respond inmonotherapy

or if there is intolerance to antipsychotic side effects. ECT in combi-

nationwith clozapine seems to have significant results allowing the

patients to achieve rapid control of psychotic symptoms with fewer

side effects, comparing with antipsychotics-association strategies.

Objectives

To summarized the latest literature about this field

and to present recent data from the Electrovulsivetherapy Unit, in

Hospital de Magalhães Lemos, Portugal.

Aim

To explore and critically review the controversies of

electroconvulsive therapy in the management of drug-resistant

schizophrenia.

Methods

Retrospective data of an Electroconvulsive TherapyUnit

during 2006–2015 was review.

Results

198 ECT treatments in schizophrenic patients were per-

formed in our unit, during 2006–2007, in a total of 647 ECT (30,6%).

In 2014–2015, 945 schizophrenic patients received ECT treatment,

in a total of 2149 performed ECT (43,9%).

Conclusions

Although guidelines are crucial for the uniform

practice of medicine, sometimes is important to be critical about

them. The use of ECT in schizophrenia is safe and effective and

further research is needed to continue to support this treatment.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.671

EW554

Symptoms of schizophrenia and

suicidal behaviour

M. Sisek- ˇSprem

∗

, M.

Herceg , V. Juki´c

University Psychiatric Hospital Vrapˇce, Integral Ward, Zagreb,

Croatia

∗

Corresponding author.

Introduction

Risk prediction for suicide in schizophrenia is

known to be complex. Illness-related risk factors are important

predictors, with number of prior suicide attempts, depressive

symptoms, active hallucinations and delusions.

Aims

To analyze the impact of clinical features of schizophrenia

on suicidal behaviour and analyze relationship between violence

and suicidality.

Methods

We compared a group of 28 suicidal, 32 hetero-

aggressive and 60 non-aggressive male patients with schizophre-

nia. The severity of the psychopathologywas assessed using PANSS,

hetero-aggressiveness using OAS and suicidality using C-SSRS and

InterSePT scales.

Results

Suicidality is in positive correlation with the presence

of depression (

= 0.485,

< 0.001) and imperative hallucinations

(

= 0.391,

< 0.001) but in negative correlation with total PANSS

score (

= –0.297,

< 0.001), impulsiveness (

= –0,237,

< 0.001)

and hetero-aggressive behaviour (

= –0.551,

< 0.001). Previous

attempt was found in 53% suicidal patients (

= 0.047). Heteroag-

gressiveness is in positive correlation with total PANSS (

= 0.43,

< 0.001) and impulsive behaviour (

= 0.57,

< 0.001). This study

supports the contention that high impulsivity in schizophrenia

patients is significant in the etiology of violent but not suicidal

behaviour.

Conclusion

In the order to diminish the level of suicide among

patients with schizophrenia we must be aware of the importance

of depressive symptoms, imperative hallucinations and previous

attempts. This study supports the contention that high impulsivity

in schizophrenia patients is significant in the etiology of violence

but not suicidal behaviour.

Keywords

Schizophrenia; Suicidality; Clinical features

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.672

EW555

Second-generation antipsychotics and

the metabolic syndrome in drug-naive

adolescents

C. Sjo

∗

, N. Bilenberg

Research Unit for Child- and Adolescent Psychiatry Odense-

Psychiatric Hospital and University of Southern Denmark, Psychiatric

Hospital and University of Southern Denmark, Odense, Denmark

∗

Corresponding author.

Introduction

Poor physical health and shorter life expectancy

often follows from mental illness. If the disorder starts in child-

hood/adolescence, the risk of this outcome is even higher. Second

generation antipsychotics (SGAs) are suspected to increase cardio-

vascular risk factors through the development of the metabolic

syndrome.

Objective

We investigated all the aspects of the metabolic syn-

drome in drug-naive youth, over a period of 12months of treatment

with SGAs.