European Psychiatry - Volume 33 - March 2016

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S302 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348
Negative Syndrome Scale (PANSS) (symptoms) and the Global
Assessment of Functioning Scale (GAF) (functioning). The dose
of antipsychotic medications was calculated in chlorpromazine
equivalents (ChlorpromEqs). Antipsychotic polypharmacy versus
monotherapy receipt and the total duration of pharmacothe-
rapy were also recorded. Multiple linear regression models were
employed to investigate the relationship of BVRT total errors
with PANSS total and subscales’ scores, controlling for antipsy-
chotic dose, receipt of antipsychotic polypharmacy and duration of
pharmacotherapy.
Results The mean age of participants (32 males, 8 females)
was 43.07 years (standard deviation [SD] = 12), mean duration of
pharmacotherapy = 15.94 years (SD = 9.65), meanGAF score = 55.16
(SD = 9.76) and the mean antipsychotic dose = 937.26 (SD = 630.39)
ChlorpromEqs. Twenty-four individuals were receiving polyphar-
macy and 16 monotherapy. The PANSS total score was positively
associated with the number of total errors in BVRT (B = 0.152, 95%
CI = 0.048, 0.256, t = 3.06, P = 0.006). This association was driven
by the relationship of visual memory errors with PANSS nega-
tive (B = 0.310, 95% CI = 0.053, 0.568, t = 2.53, P = 0.021) and general
psychopathology (B = 0.237, 95% CI = 0.1, 0.374, t = 3.63, P = 0.02)
scores. The relationship of visual memory performance with posi-
tive symptoms was not significant.
Conclusions Visual memory deficits are associated with negative
and general psychopathology symptoms in schizophrenia.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW530
COMT polymorphisms and
Mini-Mental State Examination
performance in schizophrenia
D. Kontis ∗ heochari rigoriou oulas
M. Kafritsa Vassos Andreopoulou assilouli
D. Giannakopoulou Prokopiou Avgikou
M. Kouloumpi saltas
1 Psychiatric Hospital of Attica, Unit for the Study of Cognition in
Psychosis, Athens, Greece
2 Athens University Medical School, 1st Department of Psychiatry,
Athens, Greece
∗ Corresponding author.
Introduction Individuals with schizophrenia have cognitive
deficits which have been associated with genetic polymor-
phisms such as those of the gene coding for the catechol-O-
methyltransferase enzyme (COMT-[rs4680]).
Aim To examine the relationship of schizophrenia diagnosis and
COMT-[rs4680] polymorphisms with the performance on theMini-
Mental State examination (MMSE).
Patients and methods Ninety-two individuals with schizophrenia
and 29 healthy controls were tested on the MMSE. COMT polymor-
phisms were characterized using the Restriction Fragment Length
Polymorphisms method from DNA isolated from peripheral blood
sample lymphocytes. Hierarchical linear regression analysis was
used to examine the COMT polymorphisms X diagnosis interaction
and the effects on MMSE scores, controlling for age and education.
Results Individuals with schizophrenia versus healthy controls
had a mean age of 43.69 (standard deviation [SD] = 9.71) versus
43.79 (SD = 7.80) years and mean education of 10.92 (SD = 3.42)
versus 12.82 (2.91) years. The two groups significantly differed
in education (Mann-Whitney z = 2.55, P = 0.011). We found no evi-
dence that COMT polymorphismsmoderated any effect of diagnosis
onMMSE or that they are associatedwithMMSE performance. Indi-
viduals with schizophrenia had lower MMSE scores than controls
(mean difference = 1.676; 95% Confidence Interval = 0.499, 2.85;
t = 2.822, df = 115; P = 0.006).
Conclusion Schizophrenia patients have lower MMSE scores con-
trolling for the effect of age and education. COMT polymorphisms
are not associated with MMSE scores.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW531
Is clinical global impression
associated with intelligence in
schizophrenia?
D. Kontis ∗ heochari Andreopoulou Grigoriou
K. Goulas , M. Kafritsa , S. Vasilouli , D. Giannakopoulou ,
D. Vassos , A. Melachrinou , A. Tsichlakis , E. Tsaltas
1 Psychiatric hospital of Attica, unit for the study of cognition in
psychosis, Athens, Greece
2 Athens University Medical School, 1st Department of Psychiatry,
Athens, Greece
∗ Corresponding author.
Introduction The findings of studies examining the association
of cognition with symptoms or functioning in schizophrenia are
contradictory.
Aim To investigate the clinical and functional correlates of gen-
eral intelligence in schizophrenia.
Method Forty-nine stabilized individuals with schizophrenia
were recruited in a cross-sectional study. Intelligence was assessed
using the Wechsler Adult Intelligence Scale III (WAIS). Clinical
symptoms were measured with the Positive and Negative Syn-
drome Scale (PANSS) and the Clinical Global Impression Scale (CGI).
Functioning was assessed with the Global Assessment of Function-
ing Scale (GAF) and the Strauss-Carpenter Scale (SCS). Separate
linear regression analyses were conducted using WAIS full scale
as the dependent variable and the following predictors: PANSS
total or PANSS positive or PANSS negative scores or CGI or GAF or
SCS scores. Significant predictors were entered in one final overall
model. Age and gender were entered as covariates in all analyses.
Results ANOVA models for PANSS total, positive and nega-
tive psychopathology scores and SCS scores were not significant.
However, negative symptoms were inversely associated with
intelligence (B = −0.61, 95% CI = −1.012, −0.209, t = −3.06, df = 45,
P = 0.004). CGI scores inversely correlated with WAIS total scores
(B = −6.078, 95% CI = −9.029, −3.128, t = −4.151, df = 44, P < 0.001).
GAF was positively associated with intelligence (B = 0.336, 95%
CI = 0.084, 0.589, t = 2.679, df = 45, P = 0.01). In the final (overall)
model, only CGI remained significant. One unit increase in CGI
(e.g. mildly versus moderately ill) was associated with 5.2 units
decrease in full IQ scores (B = −5.168, 95% CI = −9.257, −1.078,
t = −2.550, df = 0.002, P = 0.015).
Conclusions Clinical global impression of stabilized individuals
with schizophrenia predicts their level of general intelligence.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW532
Serum hormone levels and cognitive
functioning in male schizophrenia
patients
K. Krysta ∗, A. Bratek , A. Ko´zmin-Burzy ´nska ,
I. Krupka-Matuszczyk
Medical university of Silesia, department of psychiatry and
psychotherapy, Katowice, Poland
∗ Corresponding author.
Background Hormones deregulation is a common feature in
schizophrenia. Among the hormones that gained increased interest