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S302

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

Negative Syndrome Scale (PANSS) (symptoms) and the Global

Assessment of Functioning Scale (GAF) (functioning). The dose

of antipsychotic medications was calculated in chlorpromazine

equivalents (ChlorpromEqs). Antipsychotic polypharmacy versus

monotherapy receipt and the total duration of pharmacothe-

rapy were also recorded. Multiple linear regression models were

employed to investigate the relationship of BVRT total errors

with PANSS total and subscales’ scores, controlling for antipsy-

chotic dose, receipt of antipsychotic polypharmacy and duration of

pharmacotherapy.

Results

The mean age of participants (32 males, 8 females)

was 43.07 years (standard deviation [SD] = 12), mean duration of

pharmacotherapy = 15.94 years (SD = 9.65), meanGAF score = 55.16

(SD = 9.76) and the mean antipsychotic dose = 937.26 (SD = 630.39)

ChlorpromEqs. Twenty-four individuals were receiving polyphar-

macy and 16 monotherapy. The PANSS total score was positively

associated with the number of total errors in BVRT (B = 0.152, 95%

CI = 0.048, 0.256,

t

= 3.06,

P

= 0.006). This association was driven

by the relationship of visual memory errors with PANSS nega-

tive (B = 0.310, 95% CI = 0.053, 0.568,

t

= 2.53,

P

= 0.021) and general

psychopathology (B = 0.237, 95% CI = 0.1, 0.374,

t

= 3.63,

P

= 0.02)

scores. The relationship of visual memory performance with posi-

tive symptoms was not significant.

Conclusions

Visual memory deficits are associated with negative

and general psychopathology symptoms in schizophrenia.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.647

EW530

COMT polymorphisms and

Mini-Mental State Examination

performance in schizophrenia

D. Kontis

1 , 2 ,

, E . T

heochari

1 , 2 , V . G

rigoriou

1 , K. G

oulas

1 ,

M. Kafritsa

1 , D.

Vassos

1 , A.

Andreopoulou

1 , S. V

assilouli

1 ,

D. Giannakopoulou

1 , A.

Prokopiou

1 , V.

Avgikou

1 ,

M. Kouloumpi

1 , E. T

saltas

2

1

Psychiatric Hospital of Attica, Unit for the Study of Cognition in

Psychosis, Athens, Greece

2

Athens University Medical School, 1st Department of Psychiatry,

Athens, Greece

Corresponding author.

Introduction

Individuals with schizophrenia have cognitive

deficits which have been associated with genetic polymor-

phisms such as those of the gene coding for the catechol-O-

methyltransferase enzyme (COMT-[rs4680]).

Aim

To examine the relationship of schizophrenia diagnosis and

COMT-[rs4680] polymorphisms with the performance on theMini-

Mental State examination (MMSE).

Patients and methods

Ninety-two individuals with schizophrenia

and 29 healthy controls were tested on the MMSE. COMT polymor-

phisms were characterized using the Restriction Fragment Length

Polymorphisms method from DNA isolated from peripheral blood

sample lymphocytes. Hierarchical linear regression analysis was

used to examine the COMT polymorphisms X diagnosis interaction

and the effects on MMSE scores, controlling for age and education.

Results

Individuals with schizophrenia versus healthy controls

had a mean age of 43.69 (standard deviation [SD] = 9.71) versus

43.79 (SD = 7.80) years and mean education of 10.92 (SD = 3.42)

versus 12.82 (2.91) years. The two groups significantly differed

in education (Mann-Whitney z = 2.55,

P

= 0.011). We found no evi-

dence that COMT polymorphismsmoderated any effect of diagnosis

onMMSE or that they are associatedwithMMSE performance. Indi-

viduals with schizophrenia had lower MMSE scores than controls

(mean difference = 1.676; 95% Confidence Interval = 0.499, 2.85;

t

= 2.822, df = 115;

P

= 0.006).

Conclusion

Schizophrenia patients have lower MMSE scores con-

trolling for the effect of age and education. COMT polymorphisms

are not associated with MMSE scores.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.648

EW531

Is clinical global impression

associated with intelligence in

schizophrenia?

D. Kontis

1 , 2 ,

, E . T

heochari

1 , 2 , A .

Andreopoulou

1 , V.

Grigoriou

1 ,

K. Goulas

1

, M. Kafritsa

1

, S. Vasilouli

1

, D. Giannakopoulou

1

,

D. Vassos

1

, A. Melachrinou

1

, A. Tsichlakis

1

, E. Tsaltas

2

1

Psychiatric hospital of Attica, unit for the study of cognition in

psychosis, Athens, Greece

2

Athens University Medical School, 1st Department of Psychiatry,

Athens, Greece

Corresponding author.

Introduction

The findings of studies examining the association

of cognition with symptoms or functioning in schizophrenia are

contradictory.

Aim

To investigate the clinical and functional correlates of gen-

eral intelligence in schizophrenia.

Method

Forty-nine stabilized individuals with schizophrenia

were recruited in a cross-sectional study. Intelligence was assessed

using the Wechsler Adult Intelligence Scale III (WAIS). Clinical

symptoms were measured with the Positive and Negative Syn-

drome Scale (PANSS) and the Clinical Global Impression Scale (CGI).

Functioning was assessed with the Global Assessment of Function-

ing Scale (GAF) and the Strauss-Carpenter Scale (SCS). Separate

linear regression analyses were conducted using WAIS full scale

as the dependent variable and the following predictors: PANSS

total or PANSS positive or PANSS negative scores or CGI or GAF or

SCS scores. Significant predictors were entered in one final overall

model. Age and gender were entered as covariates in all analyses.

Results

ANOVA models for PANSS total, positive and nega-

tive psychopathology scores and SCS scores were not significant.

However, negative symptoms were inversely associated with

intelligence (B =

0.61, 95% CI =

1.012,

0.209,

t

=

3.06, df = 45,

P

= 0.004). CGI scores inversely correlated with WAIS total scores

(B =

6.078, 95% CI =

9.029,

3.128,

t

=

4.151, df = 44,

P

< 0.001).

GAF was positively associated with intelligence (B = 0.336, 95%

CI = 0.084, 0.589,

t

= 2.679, df = 45,

P

= 0.01). In the final (overall)

model, only CGI remained significant. One unit increase in CGI

(e.g. mildly versus moderately ill) was associated with 5.2 units

decrease in full IQ scores (B =

5.168, 95% CI =

9.257,

1.078,

t

=

2.550, df = 0.002,

P

= 0.015).

Conclusions

Clinical global impression of stabilized individuals

with schizophrenia predicts their level of general intelligence.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.649

EW532

Serum hormone levels and cognitive

functioning in male schizophrenia

patients

K. Krysta

, A. Bratek , A. Ko´zmin-Burzy ´nska ,

I. Krupka-Matuszczyk

Medical university of Silesia, department of psychiatry and

psychotherapy, Katowice, Poland

Corresponding author.

Background

Hormones deregulation is a common feature in

schizophrenia. Among the hormones that gained increased interest