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S300

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

Fig. 1

Q-les-Q domains in the controls and the patients. Statis-

tically significant relation was marked by *. *

P

< 0.05; **

P

< 0.01;

***

P

< 0.001.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.642

EW525

Cognitive function in early psychosis

patients from a low-income country

M.O. Husain

1 ,

, I.B. Chaudhry

2

, T. Kiran

2

, R. Thomasson

3

,

N. Mehmood

4

, N. Husain

2

1

Manchester mental health and social care Trust, general adult

psychiatry, Manchester, United Kingdom

2

University of Manchester, psychiatry, Manchester, United Kingdom

3

Penine acute care NHS Trust, psychiatry, Manchester, United

Kingdom

4

Pakistan institute of learning and living, research and development,

Karachi, Pakistan

Corresponding author.

Background

Cognitive impairments are well established findings

in schizophrenia and are associated with significant impairment of

social functioning. Episodic memory, working memory and execu-

tive function test scores are typically 1 standard deviation below

healthy controls. There are reports suggesting the presence of neu-

rocognitive deficits prior to illness onset, opening the possibility

of using cognitive profiles as disease markers. Interest in exploring

cognitive functioning in early stages schizophrenia has continued

to grow, as earlier treatments could possibly lead to improved out-

comes.

Methods

This is a cross-sectional assessment of cognitive profiles

in patients with early psychosis. A total of 51 patients suffering

from psychosis in the age group of 18–65 years were recruited and

matched with 51 healthy controls. A wide range of neurocogni-

tive domains were assessed using standardised neuropsychological

tests.

Results

There was evidence of statistically significant impair-

ments in cognitive functioning across a broad range of cognitive

domains in early-psychosis patients, as compared to healthy con-

trols. More pronounced deficits were seen in executive function

tests.

Conclusions

To our knowledge, this is the first study to report

cognitive deficits across a range of domains in patients with first

episode psychosis from a low-income country. This study found

deficits across multiple domains, including language, memory,

attention, executive function, and visuospatial function in patients

with early psychosis. Evidence of neuropsychological deficits in

the early course of the disease may highlight crucial therapeutic

windows for both pharmacological treatments and cognitive reha-

bilitation. This may improve functional outcomes in this patient

group in the longer term.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.643

EW526

Short-term compliance in

first-episode psychosis

N. Iriarte Yoller

1 ,

, J. V

icente Garcí

a 1 , F. R

ico Villademoros

2

1

Hospital universitario de Burgos, psiquiatría, Burgos, Spain

2

Instituto de neurociencias, universidad de Granada, Granada, Spain

Corresponding author.

Introduction

Non-compliance is a significant problem in patients

with first-episode psychosis (FEP), representing a challenge for

mental health professionals due to the heterogeneous course and

functional outcomes.

Objectives

The aimwas to describe the short-term compliance in

FEP and analyze the demographics, clinical features, and manage-

ment issues potentially associated with non-compliance.

Methods

This observational and retrospective study included all

consecutive FEP admitted to our psychiatry unit from January to

June 2015, belonging to our catchment area. To be categorized as

compliant, patients had to attend month-1 and month-3 follow-up

visits. Characteristics of compliant and non-compliant were com-

pared using a bivariate analysis.

Results

We included 18 patients whose characteristics are

shown in the table. Overall, 8 (44.4%) were non-compliant. Patients

who were non-compliant had a significantly shorter length of stay

(10.3 [6.3] vs. 18.5 [8.9] days). Most patients (66.7%) had cannabis

abuse, being slightly more frequent among non-compliant (75% vs.

60%,

P

=NS); in addition, the diagnosis of substance-induced psy-

chotic disorder was alsomore common among non-compliant (50%

vs 20%,

P

=NS). There were 2 patients who were readmitted, both

in the non-compliant group (Table 1).

Conclusions

Short-term non-compliance is high among patients

with FEP. Despite the limitations of our study, our results suggest

that, beside other factors (e.g. substance abuse), non-compliance

could be associated with management-related factors.

Table 1