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S262

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

EW422

Inflammatory markers in depressed

pregnant women

S. Hergüner

1 ,

, H. Toy

2

, E. Türen

2

, H. Dülger

3

1

Necmettin Erbakan University, Meram Faculty of Medicine,

Department of Child and Adolescent Psychiatry, Konya, Turkey

2

Necmettin Erbakan Univesity Meram Faculty of Medicine,

Department of Gynecology, Konya, Turkey

3

Necmettin Erbakan University, Meram Faculty of Medicine,

Department of Biochemistry, Konya, Turkey

Corresponding author.

Objectives

In the literature, there are limited number of studies

investigating the relation between depression and inflammatory

markers, including cytokines TNF alfa, and IL-6. In this study, we

aimed to examine the association between TNF alfa, and IL-6 levels

and depression, and anxiety levels in pregnant women.

Methods

The study group consisted of 145 pregnant women who

were their first and singletonpregnancies during their 28–36weeks

of gestation without any chronic physical conditions. They ful-

filled Edinburgh Postpartum Depression Scale (EPDS) and State

Trait Anxiety Inventory (STAI). Their blood was taken after they

completed the questionnaires and levels of TNF alfa, and IL-6 were

examined.

Results

The mean age of the participants were 23.2

±

4.5 years

and mean gestation week was 32.9

±

2.7. According to the EPDS

score, we divided the group into 2, as probable depressive (

12)

and non-depressive (< 12). There were no difference between the

two groups in terms of age, education, and gestational age. Women

with depression had significantly higher TNF alfa, and IL-6 levels

than non-depressive group.

Conclusion

Our findings support that depression in pregnant

women may be related with inflammatory process.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.540

EW423

Immunomodulatory role of

paliperidone in the poly(I:C) model of

schizophrenia

K. MacDowell

1 , 2 ,

, E. Munarriz-Cuezva

2 , 3

,

D. Martín-Hernández

1 , 2

, A. Sayd

1 , 2

, B. García-Bueno

1 , 2

,

J. Meana

2 , 3

1

University Complutense of Madrid-School of Medicine,

Pharmacology, Madrid, Spain

2

Centro de Investigación Biomédica en Red en el Área de Salud

Mental, CIBERSAM, Madrid, Spain

3

University of Basque Country UPV/EHU, Bizkaia, Department of

Pharmacology, Bilbao, Spain

Corresponding author.

Introduction

Alterations on the innate inflammatory response

may underlie the pathophysiology of psychiatric diseases, but

the mechanisms implicated remain elusive. Current antipsychotics

modulate pro/anti-inflammatory pathways, but the specific mech-

anisms involved remain elusive. One attractive possibility is the

regulation of the intracellular signalling pathways of the innate

immune receptors Toll-like 3 (TLR3), which triggers antiviral and

inflammatory responses.

Aims

To elucidate the regulatory role of paliperidone onmaternal

immune activation (MIA) induced alterations on TLR3 pathway and

on the two emerging endogenous antiinflammatory/antioxidant

mechanisms NRF2/antioxidant enzymes pathway and the cytokine

milieu regulating M1/M2 polarization in microglia.

Methods

Pregnant mice were treated with the synthetic Toll-like

Receptor 3 (TLR3) agonist Poly(I:C) in gestational day 9 and chron-

ically treated with paliperidone (0,05mg/kg i.p.) in adult offspring.

Animals were sacrificed one day after treatment and behavioral

test. Inflammation oxidative stress-related mediators were ana-

lysed at mRNA and protein level in prefrontal cortex samples. In

addition, behavioral test t-maze was conducted.

Results

Paliperidone prevented TLR3 pathway activation and

the subsequent MIA-induced neuroinflammatory response. Also,

paliperidone induced an increment in the activity and protein

expression of nuclear NRF2, as well as increased mRNA levels of

the antioxidant enzymes HO1, SOD and catalase in the MIA model.

Otherwise, paliperidone increases the antiinflammatory cytokines

levels TGF and IL-10 in favour of a M2 microglia profile and

increased the levels of the M2 cellular markers ArgI and FOLR2.

Conclusions

Themodulation of neuroinflammation and enhance-

ment of endogenous antioxidant/anti-inflammatory pathways by

current andnewantipsychotics could represent an interesting ther-

apeutic strategy for the future.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.541

EW424

Psychosis among HIV-infected

patients –a serious and complex

association

M. Marinho

1 ,

, J. Marques

2 , 3

, M. Braganc¸ a

1 , 3

1

São João Hospital Centre, Clinic of Psychiatry and Mental Health,

Porto, Portugal

2

Local Healthcare Unit of Matosinhos, Clinic of Psychiatry, Porto,

Portugal

3

Faculty of Medicine of Porto University, Department of Clinical

Neurosciences and Mental Health, Porto, Portugal

Corresponding author.

Introduction

Psychosis represents an uncommon but serious

complication in the course of HIV infection, and always requires

a careful differential diagnosis.

Objectives

To provide an overview of psychosis in HIV-infected

patients.

Methods

Literature reviewbased onPubMed/MEDLINE, using the

keywords “HIV” and “psychosis”.

Results

Psychosis in HIV-positive individuals can be divided into

psychotic disorders predating HIV infection and new-onset psy-

chotic disorders in HIV-seropositive patients. The pathophysiology

of psychosis in this population is complex and a multifactorial

etiology is likely in most instances. The authors will analyze

them and describe the differences of psychopathological pattern

in first-episode psychosis between HIV-positive and HIV-negative

patients. Antipsychotic agents are the treatments of choice regard-

less of the underlying diagnosis. However, they should always be

used at the lowest possible dose for the shortest possible dura-

tion. Increased sensitivity to extrapyramidal reactions, high risk for

dyslipidemia and hyperglycemia, potential interactions between

HAART and some antipsychotic agents are also important consid-

erations. Importantly, psychosis may be a harbinger of dementia.

Cross-sectional studies have also suggested that psychosis may

adversely impact the morbidity and mortality associated with HIV-

infection.

Conclusions

Psychosis disorders may arise before or at any time

during the course of HIV infection. A solid understanding of the

complex relationship between psychosis and HIV allows for better

evaluation and more effective treatment for psychotic individuals

at risk for or infected with HIV. Thus, both HIV care programs and

psychiatric care clinics should bemade familiar with this important

subject.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.542