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S264

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

1 family had 5 members participating. One hundred ninety-four

(42.8%) were children and 259 (57.2%) were parents. The mean age

of the childrenwas 23.62 (SD: 6.35) and 68 (35%) were males. Mean

age of the parents was 51.4 (SD: 8.2) and 117 (45.2%) were males.

SCL-90 identified 183 participants as caseness. Multilevel analysis

showed that individual psychopathology (caseness) was the only

statistical significant factor for family dysfunctioning.

Conclusion

There is strong association between family dysfunc-

tion and psychopathology of a member. Dysfunctional families

need further psychiatric evaluation of the members. Cause-effect

cannot be concluded from this cross-sectional study.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.545

EW428

Subthreshold depression as a

predictor of emergence and

persistence of psychotic experiences:

A six-year longitudinal

population-based cohort

H. Elbi

1 ,

, T. Binbay

2

, U. Kırlı

1

, B. Kayahan

1

, H. Onay

3

,

F. Özkınay

3

, K. Alptekin

2

1

Ege University Faculty of Medicine, Department of Psychiatry, Izmir,

Turkey

2

Dokuz Eylul University Faculty of Medicine, Department of

Psychiatry, Izmir, Turkey

3

Ege University Faculty of Medicine, Department of Medical

Genetics, Izmir, Turkey

Corresponding author.

Introduction

Subthreshold depression is prevalent in general

population and is associated with poorer quality of life, higher

health care use and increased risk of mental disorders mainly

depression.

Objectives

Testing predictive impact of subthreshold depression

on emergence and persistence of subclinical psychotic experiences.

Aims

To assess associationbetween subthresholddepression and

persistence of subclinical psychotic experiences in a 6-year follow-

up of a representative general population sample.

Methods

A longitudinal prospective cohort study (the TürkSch

The Izmir Mental Health Survey for Gene–Environment in Psy-

choses) was conductedwith a general population sample (

n

= 4011)

from Izmir, Turkey, who were 15–64 years of age at baseline.

Sociodemographic factors, subthreshold depression (based on

responses to systematic screening questions of the relevant ques-

tions with having less than five symptoms or having symptoms

less than two weeks or having non-interfering impairment due

to symptoms), and measures of psychopathology (subclinical psy-

chotic experiences) were assessed across two waves (T

1

-2008 and

T

2

-2014;

n

= 2192) using the Composite International Diagnostic

Interview.

Results

Prevalence estimates of subthreshold depression at

T

1

and persisted psychotic experiences were 4.2% and 8.3%,

respectively. Subthreshold depression at T

1

was associated with

persistence (OR = 1.6; 95% CI = 0.6–2.9) of psychotic experiences at

T

2

.

Conclusions

Psychosis may be a poor outcome of subthreshold

extended phenotypes in the general population with early expres-

sion of sets of symptoms blending from depressive, anxious and

psychotic states. Assessing the early dynamics of symptoms that

affect each other over time may facilitate the understanding of the

dynamic circuit of early psychopathology.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.546

EW429

Thought overactivation as a marker of

bipolar disorder

M. Ferrari

1 ,

, P. Ossola

1

, V. Lucarini

1

, V. Accardi

1

, C. De Panfilis

1

,

M. Tonna

2

, C. Marchesi

1

1

University of Parma, Department of Neuroscience, Parma, Italy

2

Local Health Agency, Mental Health Department, Parma, Italy

Corresponding author.

Introduction

Recent studies have underlined the importance of

considering the form of thoughts, beyond their content, in order to

achieve a better phenomenological comprehensionofmental states

in mood disorders. The subjective experience of thought overacti-

vation is an important feature of mood disorders that could help in

identifying, among patients with a depressive episode, those who

belong to the bipolar spectrum.

Objectives

Patients with a diagnosis of bipolar disorder (BD) were

compared with matched healthy controls (HC) on a scale that eval-

uates thought overactivation.

Aims

Validate the Italian version of a scale for thought overacti-

vation (i.e. STOQ) in a sample of bipolar patients.

Methods

Thirty euthymic BD and 30 HC completed the Subjec-

tive Thought Overactivation Questionnaire (STOQ), the Ruminative

Responses Scale (RRS), the Beck Depression Inventory-II (BDI-II)

and global functioning (VGF).

Results

The 9-items version of the STOQ has been back trans-

lated and its internal consistency in this sample was satisfactory

(alpha = .91). Both the brooding subscore of RRS (b-RRS) (

r

= .706;

P

< .001) and STOQ (

r

= .664;

P

< .001) correlate significantly with

depressive symptoms whereas only the first correlate with VGF

(

r

= –.801;

P

< .001). The two groups did not differed in the b-RRS

(HC = 8.41 vs BD = 9.72;

P

= .21), whereas BD where significantly

higher in the STOQ total score (HC = 6.62 vs. BD = 14.9;

P

= .007).

Conclusion

Our results, although limited by the small sample

size, confirm the validity of the STOQ and suggest that this scale

could grasp a feature characteristic of BD, independently from their

tendency to ruminate. The latter seems to impact more on global

functioning.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.547

EW430

Psychometric evaluation of a 33-item

subset of MOODS-SR for

distinguishing bipolar disorder

M. Ioannou

1 ,

, M. Dellepiane

1

, A. Benvenuti

2

, K. Feloukatzis

1

,

N. Skondra

1

, S. Steingrimsson

3

1

University of Gothenburg, Institute of Medicine, Psykiatri Affektiva,

Gothenburg, Sweden

2

University of Pisa, Section of Psychiatry, Department of Clinical and

Experimental Medicine, Pisa, Italy

3

University of Gothenburg, Centre of Ethics, Law and Mental Health

CELAM, Gothenburg, Sweden

Corresponding author.

Introduction

The MOODS-SR is a self-report instrument consist-

ing of 161 dichotomous items. It is designed to assess lifetime

presence of mood spectrum psychopathology. Recently, it has been

proposed that a subset of 33 items can be used to distinguishing

bipolar disorder.

Aim

To evaluate psychometric properties of a 33-itemsubset and

to propose a clinically relevant cut-off for screening for bipolar

disorder.

Methods

Patients with mood disorders were recruited from out-

patient services at Sahlgrenska University Hospital. Patients and a

convenience sample of healthy controls were offered to fill in the