European Psychiatry - Volume 33 - March 2016

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S264 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348
1 family had 5 members participating. One hundred ninety-four
(42.8%) were children and 259 (57.2%) were parents. The mean age
of the childrenwas 23.62 (SD: 6.35) and 68 (35%) were males. Mean
age of the parents was 51.4 (SD: 8.2) and 117 (45.2%) were males.
SCL-90 identified 183 participants as caseness. Multilevel analysis
showed that individual psychopathology (caseness) was the only
statistical significant factor for family dysfunctioning.
Conclusion There is strong association between family dysfunc-
tion and psychopathology of a member. Dysfunctional families
need further psychiatric evaluation of the members. Cause-effect
cannot be concluded from this cross-sectional study.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW428
Subthreshold depression as a
predictor of emergence and
persistence of psychotic experiences:
A six-year longitudinal
population-based cohort
H. Elbi ∗, T. Binbay , U. Kırlı , B. Kayahan , H. Onay ,
F. Özkınay , K. Alptekin
1 Ege University Faculty of Medicine, Department of Psychiatry, Izmir,
Turkey
2 Dokuz Eylul University Faculty of Medicine, Department of
Psychiatry, Izmir, Turkey
3 Ege University Faculty of Medicine, Department of Medical
Genetics, Izmir, Turkey
∗ Corresponding author.
Introduction Subthreshold depression is prevalent in general
population and is associated with poorer quality of life, higher
health care use and increased risk of mental disorders mainly
depression.
Objectives Testing predictive impact of subthreshold depression
on emergence and persistence of subclinical psychotic experiences.
Aims To assess associationbetween subthresholddepression and
persistence of subclinical psychotic experiences in a 6-year follow-
up of a representative general population sample.
Methods A longitudinal prospective cohort study (the TürkSch
The Izmir Mental Health Survey for Gene–Environment in Psy-
choses) was conductedwith a general population sample (n = 4011)
from Izmir, Turkey, who were 15–64 years of age at baseline.
Sociodemographic factors, subthreshold depression (based on
responses to systematic screening questions of the relevant ques-
tions with having less than five symptoms or having symptoms
less than two weeks or having non-interfering impairment due
to symptoms), and measures of psychopathology (subclinical psy-
chotic experiences) were assessed across two waves (T1-2008 and
T2-2014; n = 2192) using the Composite International Diagnostic
Interview.
Results Prevalence estimates of subthreshold depression at
T1 and persisted psychotic experiences were 4.2% and 8.3%,
respectively. Subthreshold depression at T1 was associated with
persistence (OR = 1.6; 95% CI = 0.6–2.9) of psychotic experiences at
T2.
Conclusions Psychosis may be a poor outcome of subthreshold
extended phenotypes in the general population with early expres-
sion of sets of symptoms blending from depressive, anxious and
psychotic states. Assessing the early dynamics of symptoms that
affect each other over time may facilitate the understanding of the
dynamic circuit of early psychopathology.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW429
Thought overactivation as a marker of
bipolar disorder
M. Ferrari ∗, P. Ossola , V. Lucarini , V. Accardi , C. De Panfilis ,
M. Tonna , C. Marchesi
1 University of Parma, Department of Neuroscience, Parma, Italy
2 Local Health Agency, Mental Health Department, Parma, Italy
∗ Corresponding author.
Introduction Recent studies have underlined the importance of
considering the form of thoughts, beyond their content, in order to
achieve a better phenomenological comprehensionofmental states
in mood disorders. The subjective experience of thought overacti-
vation is an important feature of mood disorders that could help in
identifying, among patients with a depressive episode, those who
belong to the bipolar spectrum.
Objectives Patients with a diagnosis of bipolar disorder (BD) were
compared with matched healthy controls (HC) on a scale that eval-
uates thought overactivation.
Aims Validate the Italian version of a scale for thought overacti-
vation (i.e. STOQ) in a sample of bipolar patients.
Methods Thirty euthymic BD and 30 HC completed the Subjec-
tive Thought Overactivation Questionnaire (STOQ), the Ruminative
Responses Scale (RRS), the Beck Depression Inventory-II (BDI-II)
and global functioning (VGF).
Results The 9-items version of the STOQ has been back trans-
lated and its internal consistency in this sample was satisfactory
(alpha = .91). Both the brooding subscore of RRS (b-RRS) ( r= .706;
P < .001) and STOQ (r = .664; P < .001) correlate significantly with
depressive symptoms whereas only the first correlate with VGF
(r = –.801; P < .001). The two groups did not differed in the b-RRS
(HC = 8.41 vs BD = 9.72; P = .21), whereas BD where significantly
higher in the STOQ total score (HC = 6.62 vs. BD = 14.9; P = .007).
Conclusion Our results, although limited by the small sample
size, confirm the validity of the STOQ and suggest that this scale
could grasp a feature characteristic of BD, independently from their
tendency to ruminate. The latter seems to impact more on global
functioning.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW430
Psychometric evaluation of a 33-item
subset of MOODS-SR for
distinguishing bipolar disorder
M. Ioannou ∗, M. Dellepiane , A. Benvenuti , K. Feloukatzis ,
N. Skondra , S. Steingrimsson
1 University of Gothenburg, Institute of Medicine, Psykiatri Affektiva,
Gothenburg, Sweden
2 University of Pisa, Section of Psychiatry, Department of Clinical and
Experimental Medicine, Pisa, Italy
3 University of Gothenburg, Centre of Ethics, Law and Mental Health
CELAM, Gothenburg, Sweden
∗ Corresponding author.
Introduction The MOODS-SR is a self-report instrument consist-
ing of 161 dichotomous items. It is designed to assess lifetime
presence of mood spectrum psychopathology. Recently, it has been
proposed that a subset of 33 items can be used to distinguishing
bipolar disorder.
Aim To evaluate psychometric properties of a 33-itemsubset and
to propose a clinically relevant cut-off for screening for bipolar
disorder.
Methods Patients with mood disorders were recruited from out-
patient services at Sahlgrenska University Hospital. Patients and a
convenience sample of healthy controls were offered to fill in the