European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348 S261
Introduction The influence of the immune deregulation on the
risk and psychopathology of schizophrenia is increasingly recog-
nized in the literature.
Aim To assess the association between serum IL-1RA on
schizophrenia psychopathology.
Methods We recruited 88 schizophrenia patients (38 males
and 49 females, mean age 38.12 ± 12.67 years) and 88 healthy
adult control subjects (68 males, 20 females, mean age
40.63 ±7.99 years). Lifetime psychopathology was evaluated using
Operational Criteria for Psychotic Illness (OPCRIT) checklist, while
current psychopathology was assessed using Positive and Negative
Syndrome Scale (PANSS). Serum samples were stored in aliquots at
–80 ◦C. Serum levels of IL1-RA were measured using Immunoassay
(ELISA).
Results There were statistically significant differences
between schizophrenia patients and healthy controls
(median ± interquartile range: 350,81 ±227.04 and 888.74 ±
762.63, respectively [pg/ml]) (U Mann–Whitney test, Z = –7.99,
P < 0.0001). There were no differences in serum IL1-RA levels
between male and female among patients with schizophrenia
(U Mann–Whitney test, Z = –0.22, P= 0.82) nor among healthy
control subjects (U Mann–Whitney test, Z = –0.17, P = 0.86).
Among schizophrenia patients, there was a trend-level association
between IL-1RA serum level with negative symptoms (Spearman
correlation coefficient, r = –0.23, P = 0.056), positive symptoms
(Spearman correlation coefficient r= –0.22, P = 0.066), and on a
statistically significant level with general symptoms (Spearman
correlation coefficient r = –0.28, P = 0.018).
Conclusion SerumIL1-RA level is higher in schizophrenia patients
in comparison to healthy controls and it is associated with
schizophrenia psychopathology.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW420
The prevalence of voltage-gated
potassium channel (VGKC) and
glutamic acid decarboxylase (GAD)
autoantibodies in psychotic disorders:
A systematic review and meta-analysis
R. Grain ∗, J. Lally , A. Lemince , B. Stubbs , F. Gaughran
1 London, United Kingdom
2 Institute of Psychiatry, Psychology and Neuroscience IOPPN,
Psychosis Studies, London, United Kingdom
3 South London and Maudsley NHS Trust, South London and
Maudsley NHS Trust, London, United Kingdom
4 South London and Maudlsey NHS Trust, Physiotherapy, London,
United Kingdom
5 Institute of Psychiatry, Psychology and Neuroscience, Psychosis
Studies, London, United Kingdom
∗ Corresponding author.
Introduction Antibodies to the voltage-gated potassium channel
(VGKC) complex and glutamic acid decarboxylase (GAD) have been
reported in some cases of psychosis. We conducted the first sys-
tematic review on VGKC and GAD, and meta-analysis on GAD, to
investigate their prevalence in people with psychosis.
Objectives The objective was to examine the available evidence
to determine the prevalence of serum VGKC and GAD antibody
positivity in psychosis.
Aims To search the available literature for data indicating the
prevalence of these antibodies in psychosis. If data were sufficient,
we anticipated conducting a meta-analysis.
Methods Two authors searched major electronic databases for
studies reporting the prevalence of VGKC and GAD65 antibody
seropositivity in psychotic disorders. We then conducted a random
effects analysiswith ComprehensiveMeta-Analysis software (CMA,
Version 3).
Results Only three studies presenting prevalence rates of VGKC
sero-positivity in psychosis could be identified, with an overall
prevalence of 0.5% (1/196) with to 0% in healthy controls (0/50).
Meta-analysis established the pooled prevalence of GAD65 autoan-
tibodies was 8.67% (95% CI 3.9–17.80%, I2 = 75%, 8 studies) in
psychotic disorders. People with psychosis were more likely to
have GAD65 antibodies than controls (OR 3.14 95% CI 1.55–6.37%,
P = 0.001, 7 studies, I2 = 0%).
Conclusions Rates of VGKC antibody positivity appear to be low
in psychosis, although there is a lack of published evidence. The
prevalence of GAD65 antibodies is higher but available studies did
not control for the presence of T1 diabetes, a condition in which
GAD65 antibodies are also found.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW421
Adverse childhood experiences and
later in life depression as risk factors
for cancer incidence and mortality.
A nationally representative,
prospective longitudinal study
M.V. Hansen
Aarhus, Denmark
Introduction Adverse childhood experiences (ACEs) have shown
to influence the risk of various chronic diseases alone, and in combi-
nation with depression later in life. To date, only little research has
examined the relationship, and findings have been inconsistent.
Objective To conduct a nationwide prospective study on ACEs
and the risk of cancer.
Aims – Examine the relationship between ACE and a range of
cancer types;
– to test for a linear dose-response relationship;
– to investigate differences in the effects of the specific ACE on the
risk of cancer;
– to determine if there are any sex differences as well as windows
of vulnerability;
– to examine if later in life occurrence of depression influence the
risk of cancer in combination with ACE.
Methods A prospective population-based study including
approximately 1.1 mio individuals was conducted using linked
Danish registries that hold data on objective measures of ACEs and
cancer incidences. Survival analyses were used to estimate relative
risk of cancer among those with ACE and depression, compared to
those without, while adjusting for relevant confounders.
Results This study will provide results on the relative risk of can-
cer after exposure to ACE compared to those without, as well as
information on the combination of ACE and depression, sex differ-
ences, effect of timing and dose-response analyses.
Conclusion This preliminary study will help to further advance
our understanding on how ACES influence the risk of serious
chronic diseases later in life, and the findings may contribute to
understanding the etiology of cancer.
Disclosure of interest The author has not supplied his/her decla-
ration of competing interest.