Table of Contents Table of Contents
Previous Page  267 / 812 Next Page
Information
Show Menu
Previous Page 267 / 812 Next Page
Page Background

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

S263

EW425

Neuroleptic effect in aggressive mice

after the transplantation of immune

cells treated in vitro with

chlorpromazine

E. Markova

1 ,

, M. Knyazheva

1

, T. Shushpanova

2

1

State Research Institute of Fundamental and Clinical Immunology,

Neuroimmunology Laboratory, Novosibirsk, Russia

2

Mental Health Research Institute, Clinical neuroimmunology and

neurobiology, Tomsk, Russia

Corresponding author.

Introduction

Existence of integration, mutual relations of ner-

vous and immune systems, which cellular elements are character-

ized by expressed phenotype and functional similarity, means the

possibility of immune cells participation in the regulation of higher

nervous activity.

Objectives

Previously, we demonstrated the possibility of tar-

geted regulation of animal’s behavior by the transplantation of

immune cells with definite functional characteristics. Based on the

our previous research results in the present study, we investigated

the modulating effect of the immune cells, treated in vitro with

chlorpromazine on the nervous and immune systems functional

activity in aggressive mice.

Methods

(CBA

×

C57Bl/6) F1 aggressive mice, exposed to 10-

days chronic social stress, were undergoing the transplantation

of immune cells in vitro treated with chlorpromazine. Ani-

mal’s behavioral parameters, cytokines synthesis in the brain and

immune cells before and after transplantation were estimated.

Results

It was shown that aggression is associated with the

increased production of spleen T-helper 1 cell-derived cytokines

IL-2 and IFN , as well as decreased TNF production by the spleen

mononuclear phagocyte cells. These alterations were more pro-

nounced following mitogen stimulation. Spleen cells, obtaining

from aggressive mice, were treated in vitro with chlorpromazine

and then injected intravenously into syngeneic aggressive recipi-

ents. The cell’s transplantation led to the reduction of the recipient’s

motor activity in the “open field” and Porsolt swimming tests

and normalized cytokines synthesis in the brain and immune

cells.

Conclusion

Research results demonstrated the neuroleptic effect

in aggressivemice, obtained by the transplantation of immune cells

treated in vitro with chlorpromazine.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.543

EW426

Impact of anti-inflammatory drugs on

the risk of anxiety disorders after

critical illness

C.R. Medici

1 , 2 ,

, S.D. Østergaard

3 , 4

, H.T. Sørensen

1

,

C.F. Christiansen

1

1

Aarhus University Hospital, Department of Clinical Epidemiology,

Aarhus, Denmark

2

Aarhus University Hospital, Psychiatric Research Academy,

Department of Affective Disorders, Aarhus, Denmark

3

Aarhus University Hospital, Department of Clinical Medicine,

Aarhus, Denmark

4

Aarhus University Hospital, Research Department P, Aarhus,

Denmark

Corresponding author.

Introduction

Critical illness increases the risk of mental illness,

including anxiety disorders. As critically ill patients exhibit high

levels of inflammation and inflammation plays a role in mental

illness, critical and mental illnesses may be linked by systemic

inflammation.

Objective

To investigate whether anti-inflammatory drugs

reduce the risk of subsequent anxiety disorders among intensive

care patients requiring mechanical ventilation.

Aims

To assess the risk of anxiety disorders after intensive care

requiring mechanical ventilation according to pre-admission use

of non-steroidal anti-inflammatory drugs (NSAID), glucocorticoids,

statins or combination. To compare risk in users with non-users.

Methods

This nationwide, registry-based, cohort study includes

all patients receiving mechanical ventilation in Danish intensive

care units during 2005–2013. Preadmission use of NSAIDs, glu-

cocorticoids, statins or combinations will be identified from filled

prescriptions. Risk of anxiety disorders in users and non-users of

these anti-inflammatory drugs will be estimated using the cumu-

lative incidence method, accounting for death as a competing risk.

After propensity-score matching, risk in users and non-users will

be compared using hazard ratios from a Cox regression.

Results

N/A. The estimated number of patients is 100,000.

Expected preadmission use is 14% for statins, 15% for NSAIDs, and

10% for glucocorticoids. The study will have 95% power to detect a

10% decrease in risk between users and non-users.

Conclusions

N/A. The study potentially will contribute knowl-

edge about the pathogenesis of anxiety disorders and a mechanism

linking critical illness and mental illnesses. If anti-inflammatory

drugs reduce risk of anxiety disorders, this may guide trials.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.544

Psychopathology

EW427

Family functioning and individual

psychopathology in a non-clinical

general population

D. Adamis

1 ,

, I. P

etmeza

2 , G.

McCarthy

3 , A. T

samparli

4

1

Sligo Mental Health Services, Psychiatry, Sligo, Ireland

2

National and Kapodistrian University of Athens, Early Childhood

Education, Athens, Greece

3

Sligo Mental Health Services, Sligo Medical Academy, NUI Galway,

Psychiatry, Sligo, Ireland

4

University of the Aegean, Clinical Psychology, Rhodes, Greece

Corresponding author.

Introduction

A family “constructs” an identity of its own derived

from their assumptions about relationships and the social envi-

ronment they live in. This identity transcends the individual while

at the same time encourages individual differentiation. Family

functioning is influenced from different factors like social context,

qualitative characteristics, and from individual’s medical or psychi-

atric condition.

Aims and objectives

To examined the effects of sociodemographic

factors and individual psychopathology on the function of family

in a non-clinical sample.

Methods

Cross-sectional study of participants and their families.

The follow data collected:

–demographics (age, gender, occupation, education);

–description of the family (number ofmembers, single parents fam-

ily, adoption);

–history of mental or physical illnesses;

–Family Assessment Device (FAD);

–Symptom Checklist-90 (SCL-90).

Results

The sample constituted of 151 families, (453 individuals),

in 48 families, 2 family members participated, in 56 families, 3

members participated, in 46 families 4 members participated and