European Psychiatry - Volume 33 - March 2016

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S212 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348
EW282
Borderline personality disorder and
childhood maltreatment:
A genome-wide methylation analysis
L. Stenz ∗, J. Prados , P. Courtet , P. Prada , R. Nicastro ,
W. Adouan , S. Guillaume , E. Olié , J.M. Aubry , A. Dayer ,
N. Perroud
1 Switzerland
2 Geneva university, departement of psychiatry, Geneva, Switzerland
3 Centre Hospitalier Régional Universitaire de Montpelier,
Department of Emergency Psychiatry, Montpellier, France
4 University Hospitals of Geneva, Department of Mental Health and
Psychiatry, Geneva, Switzerland
5 University of Geneva, Department of Psychiatry, Geneva,
Switzerland
6 Geneva Unviersity, Department of Psychiatry, Geneva, Switzerland
∗ Corresponding author.
Early life adversity plays a critical role in the emergence of bor-
derline personality disorder (BPD) and this could occur through
epigenetic programming. In this perspective, we aimed to deter-
mine whether childhood maltreatment could durably modify
epigenetic processes by the means of a whole-genome methyla-
tion scan of BPD subjects. Using the Illumina Infinium® Human
Methylation 450 Bead Chip, global methylation status of DNA
extracted from peripheral blood leucocytes was correlated to the
severity of childhood maltreatment in 96 BPD subjects suffering
from a high level of child adversity and 93 subjects suffering from
major depressive disorder (MDD) and reporting a low rate of child
maltreatment. Several CpGs within or near the following genes
(IL17RA, miR124-3, KCNQ2, EFNB1, OCA2,MFAP2, RPH3AL,WDR60,
CST9L, EP400, A2ML1, NT5DC2, FAM163A and SPSB2) were found
to be differently methylated, either in BPD compared with MDD
or in relation to the severity of childhood maltreatment. A highly
relevant biological result was observed for cg04927004 close to
miR124-3 thatwas significantly associatedwithBPDand severity of
childhood maltreatment. miR124-3 codes for a microRNA (miRNA)
targeting several genes previously found to be associated with BPD
such as NR3C1. Our results highlight the potentially important role
played by miRNAs in the etiology of neuropsychiatric disorders
such as BPD and the usefulness of using methylome-wide asso-
ciation studies to uncover such candidate genes. Moreover, they
offer new understanding of the impact of maltreatments on bio-
logical processes leading to diseases and may ultimately result in
the identification of relevant biomarkers.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW283
Effect of Disrupted-in-Schizophrenia
1 gene on treatment response in
patients with a first episode of
psychosis
J. Vázquez Bourgon ∗, R. Ayesa Arriola , P. Suarez Pinilla ,
R. Roiz Santia˜nez , D. Tordesillas Gutierrez ,
V. Ortiz-García de la Foz , B. Crespo-Facorro
University Hospital Marqués de Valdecilla-IDIVAL, CIBERSAM,
Psychiatry, Santander, Spain
∗ Corresponding author.
Introduction There is substantial evidence suggesting that indi-
vidual variability in antipsychotic treatment response could be
genetically determined. Disrupted-in-Schizophrenia 1 (DISC1)
gene has been previously associated to the illness and to treatment
response in a sample of patients suffering from psychosis. How-
ever, there is a lack of studies on the effect of DISC1 on treatment
response in samples of first episode psychosis.
Objectives The aim of this study was to explore the relation
between variations in DISC1 gene and treatment response to
antipsychotics in a sample of drug-naïve patients with a first
episode of psychosis.
Methods Two hundred and twenty Caucasian drug-naive
patients experiencing a first episode of non-affective psychosis
were genotyped for rs821616 (Ser704Cys), rs6675281 (Leu607Phe)
and rs1000731. Early (6 weeks) response to antipsychotic treat-
ment was assessed with the Brief Psychiatric Rating Scale, the
Scale for the Assessment of Positive Symptoms, and the Scale
for the Assessment of Negative Symptoms. Other clinical and
socio-demographic variables were recorded to eliminate potential
confounding effects.
Results We found a significant association between rs1000731
and treatment response. Thus, those patients homozygous for
the G allele of rs1000731 were more frequently non-responders,
measured with SANS, after 6 weeks of treatment, than those carry-
ing the A allele (X 2 = 4.019; P = 0.032). Moreover, when analysing
the clinical improvement longitudinally, we observed that those
patients carrying the A allele for the rs1000731 presented a
greater improvement in positive symptoms dimension (F = 8.905;
P = 0.003).
Conclusions Our results suggest a minor contribution to antipsy-
chotic drug response of genetic alterations in the DISC1 gene.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
Geriatric psychiatry
EW284
Agreement and equation between
Mini Mental State Examination
(MMSE) and Montreal Cognitive
Assessment (MoCA) in an old age
psychiatry outpatient clinic
population
D. Adamis ∗, L. Helmi , O. Fitzpatrick , D. Meagher ,
G. McCarthy
1 Sligo Mental Health Services, Psychiatry, Sligo, Ireland
2 Sligo Mental Health Services, Sligo Medical Academy, NUI Galway,
Psychiatry, Sligo, Ireland
3 Medical School, University of Limerick, Psychiatry, Limerick, Ireland
∗ Corresponding author.
Introduction Both MMSE and MoCA are two widely used cogni-
tive screening test. Comparison of the two tests has been done in
specific populations (Parkinson) but not in general elderly psychi-
atric populations. In research, equating methodologies has been
used to compare results among studies that use different scales,
which measure the same construct.
Aims To explore their level of agreement within a particular clin-
ical setting.
Objectives (a) To findMoCA andMMSE agreement. (b) To derive a
conversion formula between the two scales and test it in a random
population of similar setting.
Methods Prospective study of consecutive community dwelling
older patients who attend outpatient clinic or day hospital. Both
tests were administered from the same researcher the same day in
random order.
Results The total sample (n = 135) was randomly divided in
two. One from where the equating rule derived (n = 70) and a
second ( n = 65) in which the derived conversion was tested. Agree-
ment of the two scales (Pearson’s r) was 0.86 (P < 0.001), and