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S212

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

EW282

Borderline personality disorder and

childhood maltreatment:

A genome-wide methylation analysis

L. Stenz

1 ,

, J. Prados

2

, P. Courtet

3

, P. Prada

4

, R. Nicastro

4

,

W. Adouan

5

, S. Guillaume

3

, E. Olié

3

, J.M. Aubry

4

, A. Dayer

6

,

N. Perroud

4

1

Switzerland

2

Geneva university, departement of psychiatry, Geneva, Switzerland

3

Centre Hospitalier Régional Universitaire de Montpelier,

Department of Emergency Psychiatry, Montpellier, France

4

University Hospitals of Geneva, Department of Mental Health and

Psychiatry, Geneva, Switzerland

5

University of Geneva, Department of Psychiatry, Geneva,

Switzerland

6

Geneva Unviersity, Department of Psychiatry, Geneva, Switzerland

Corresponding author.

Early life adversity plays a critical role in the emergence of bor-

derline personality disorder (BPD) and this could occur through

epigenetic programming. In this perspective, we aimed to deter-

mine whether childhood maltreatment could durably modify

epigenetic processes by the means of a whole-genome methyla-

tion scan of BPD subjects. Using the Illumina Infinium

®

Human

Methylation 450 Bead Chip, global methylation status of DNA

extracted from peripheral blood leucocytes was correlated to the

severity of childhood maltreatment in 96 BPD subjects suffering

from a high level of child adversity and 93 subjects suffering from

major depressive disorder (MDD) and reporting a low rate of child

maltreatment. Several CpGs within or near the following genes

(IL17RA, miR124-3, KCNQ2, EFNB1, OCA2,MFAP2, RPH3AL,WDR60,

CST9L, EP400, A2ML1, NT5DC2, FAM163A and SPSB2) were found

to be differently methylated, either in BPD compared with MDD

or in relation to the severity of childhood maltreatment. A highly

relevant biological result was observed for cg04927004 close to

miR124-3 thatwas significantly associatedwithBPDand severity of

childhood maltreatment. miR124-3 codes for a microRNA (miRNA)

targeting several genes previously found to be associated with BPD

such as NR3C1. Our results highlight the potentially important role

played by miRNAs in the etiology of neuropsychiatric disorders

such as BPD and the usefulness of using methylome-wide asso-

ciation studies to uncover such candidate genes. Moreover, they

offer new understanding of the impact of maltreatments on bio-

logical processes leading to diseases and may ultimately result in

the identification of relevant biomarkers.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.400

EW283

Effect of Disrupted-in-Schizophrenia

1 gene on treatment response in

patients with a first episode of

psychosis

J. Vázquez Bourgon

, R. Ayesa Arriola , P. Suarez Pinilla ,

R. Roiz Santia˜nez , D. Tordesillas Gutierrez ,

V. Ortiz-García de la Foz , B. Crespo-Facorro

University Hospital Marqués de Valdecilla-IDIVAL, CIBERSAM,

Psychiatry, Santander, Spain

Corresponding author.

Introduction

There is substantial evidence suggesting that indi-

vidual variability in antipsychotic treatment response could be

genetically determined. Disrupted-in-Schizophrenia 1 (DISC1)

gene has been previously associated to the illness and to treatment

response in a sample of patients suffering from psychosis. How-

ever, there is a lack of studies on the effect of DISC1 on treatment

response in samples of first episode psychosis.

Objectives

The aim of this study was to explore the relation

between variations in DISC1 gene and treatment response to

antipsychotics in a sample of drug-naïve patients with a first

episode of psychosis.

Methods

Two hundred and twenty Caucasian drug-naive

patients experiencing a first episode of non-affective psychosis

were genotyped for rs821616 (Ser704Cys), rs6675281 (Leu607Phe)

and rs1000731. Early (6 weeks) response to antipsychotic treat-

ment was assessed with the Brief Psychiatric Rating Scale, the

Scale for the Assessment of Positive Symptoms, and the Scale

for the Assessment of Negative Symptoms. Other clinical and

socio-demographic variables were recorded to eliminate potential

confounding effects.

Results

We found a significant association between rs1000731

and treatment response. Thus, those patients homozygous for

the G allele of rs1000731 were more frequently non-responders,

measured with SANS, after 6 weeks of treatment, than those carry-

ing the A allele (X

2

= 4.019;

P

= 0.032). Moreover, when analysing

the clinical improvement longitudinally, we observed that those

patients carrying the A allele for the rs1000731 presented a

greater improvement in positive symptoms dimension (F = 8.905;

P

= 0.003).

Conclusions

Our results suggest a minor contribution to antipsy-

chotic drug response of genetic alterations in the DISC1 gene.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.401

Geriatric psychiatry

EW284

Agreement and equation between

Mini Mental State Examination

(MMSE) and Montreal Cognitive

Assessment (MoCA) in an old age

psychiatry outpatient clinic

population

D. Adamis

1 ,

, L. Helmi

2

, O. Fitzpatrick

1

, D. Meagher

3

,

G. McCarthy

2

1

Sligo Mental Health Services, Psychiatry, Sligo, Ireland

2

Sligo Mental Health Services, Sligo Medical Academy, NUI Galway,

Psychiatry, Sligo, Ireland

3

Medical School, University of Limerick, Psychiatry, Limerick, Ireland

Corresponding author.

Introduction

Both MMSE and MoCA are two widely used cogni-

tive screening test. Comparison of the two tests has been done in

specific populations (Parkinson) but not in general elderly psychi-

atric populations. In research, equating methodologies has been

used to compare results among studies that use different scales,

which measure the same construct.

Aims

To explore their level of agreement within a particular clin-

ical setting.

Objectives

(a) To findMoCA andMMSE agreement. (b) To derive a

conversion formula between the two scales and test it in a random

population of similar setting.

Methods

Prospective study of consecutive community dwelling

older patients who attend outpatient clinic or day hospital. Both

tests were administered from the same researcher the same day in

random order.

Results

The total sample (

n

= 135) was randomly divided in

two. One from where the equating rule derived (

n

= 70) and a

second (

n

= 65) in which the derived conversion was tested. Agree-

ment of the two scales (Pearson’s

r

) was 0.86 (

P

< 0.001), and