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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

S217

EW296

Efficacy of memantine for elderly

patients in the mild stage of

Alzheimer’s and vascular dementia in

Ukraine

V. Kholin

, N. Bachinskaya , I. Rozhelijuk

D.F. Chebotarev Institute of Gerontology NAMS of Ukraine, Age

Physiology and Pathology of Nervous System, Kiev, Ukraine

Corresponding author.

The aim of our research was to investigate the effectiveness of

memantine treatment of Ukrainian patients with Alzheimer’s (AD)

and vascular dementia (VaD) depending on existingApoE genotype.

Methods

It was a complex examination of 60 elderly persons

(72.40

±

1.35 years) with mild stage of AD and VD. The effective-

ness of response to (20mg/day) memantine intake was studied

during the first 3 months of treatment. Efficacy of short-term

treatment was determined by MMSE and the numbers of positive

statistically significant changes ADAS-cog subtests. Genetic ApoE

polymorphism was investigated too (using the of the PCR tech-

nique). Statistical Anova analysis was done.

Results

After 3 months of treatment significant changes in the

overall score of Adas-cog was observed in both groups with

some differences in subscale profiles. For AD patients, statisti-

cally positive changes (

P

< 0.05) were found in comprehension of

spoken language, naming objects, commands, ideational praxis

and delayed recall subtests. For VaD patients, statistically positive

changes (

P

< 0.05) were found in comprehension of spoken lan-

guage, naming objects, word finding difficulty and delayed recall

subtests. There was established a significant prevalence of individ-

uals with genotype 4/ 4 among patients with AD compared with

patients with VD. The main differences, according to the meman-

tine efficacy treatment in carriers ApoE3 and ApoE4 genotypes,

were in remembering test instructions subtest.

Conclusions

The memantine treatment efficacy in AD and VaD

patients in mild stage of dementia was not significantly associated

with an existing of Apo-E genotype polymorphism.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.414

EW297

A systematic literature review to

ascertain the effectiveness of using

bed-exit alarm in the prevention of

bed falls in a psycho-geriatric ward

C. Koh

Alexandra Health System, Khoo Teck Puat Hospital, Gericare@North,

Singapore, Singapore

Background and objectives

Bed exit alarms detect motion and

send alarm signals to alert caregivers when a patient is attempting

to exit a bed. Its use renders an opportunity for timely staff response

to a fall risk situation associated with unplanned/unassisted bed

exits. The utility of these devices is often appraised around the

concepts of preventing patient falls and related injuries. To acquire

further knowledge, a systematic review of literature was carried

out to generate practice-based evidence in relation to the use of

bed-exit alarms/monitors. This study was conducted: (1) to exam-

ine evidence-based articles regarding the use of bed exit alarms

in psycho-geriatric settings; and (2) to obtain and apply newly-

acquired knowledge towards assessing the effectiveness of such

devices in reducing bed fall incidents and injuries among elderly

inpatients in a psychiatric hospital in Singapore.

Methods

A systematic review of literature was the main method

used to generate evidence-based results.

Results

Due to lack of random clinical studies, all five studies

(conducted in the USA) find evidences offered on the effectives of

bed exit alarms as inconclusive. Its overall reliability in detecting

movements out of bed has not been established. The use of bed exit

alarms is useful but it should not compromise staff vigilance in any

way.

Conclusion

These findings indicate the there was little evidence

to show that bed-exit alarms have the capacity to prevent falls

totally. Decisions to use bed exit alarms as an assistive tool for

fall prevention remain open to the full discretion of any hospital

management.

Disclosure of interest

The author has not supplied his/her decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.415

EW298

Understanding adverse health effects

of widowhood in old age – A

cross-countries mixed methods study

C.B. Kristiansen

1 ,

, P. Munk-Jørgensen

2

, C. Mattisson

3

,

K. Andersen

2

1

Aarhus University hospital, Psychiatric Research Academy –

Department of Affective Disorders, Risskov, Denmark

2

Odense University Hospiral, Psychiatric Department, Odense,

Denmark

3

Lund University Hospital, Department of Clinical Sciences, Lund

Division of Psychiatry, The Lundby Study, Lund, Sweden

Corresponding author.

Introduction

Widowhood in old age increases mortality and

adverse health effects, particularly depression and need for psychi-

atric care. The causes of this are poorly understood. To study risk

factors and mechanisms, theories about what to study are needed.

Aqualitatively approach towidowhood fromthewidow/widower’s

perspective may uncover important knowledge.

Objectives

To investigate risk factors of the adverse health effects

associated with widowhood in old age from the perspective of the

widower/widowers and to test the generalisability of the theories

quantitatively.

Methods

This is a cross-country mixed methods study com-

bining narrative interviews with Danish widows/widowers and

a 50-year follow-up study from Sweden – The Lundby Study.

Widows/widowers above 65 years of age referred to in- or out-

patient treatment at the Department of Psychiatry at Odense or

Aarhus University Hospital are included. Narrative interviews are

conducted and analysed according to grounded theory. The qualita-

tively developed theorieswill then be tested quantitatively through

the Lundby Study by comparing widows/widowers above 65 years

with age-matched controls, who are still married.

Results

In the Lundby Study, 597 persons above 65 years

were identified in the latest follow-up: 176 (29.5%) were

widow/widowers, 421 (70.5%) were married/cohabitating.

Depending on the theories developed a total of 384 possible

variables regarding physical health, mental health and general

living circumstances are tested. Further results will be presented.

Conclusions

The causes of adverse health effects in widowhood

are poorly understood. This study will potentially contribute to

unravelling these by identifying possible risk factors.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.416