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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

S221

EW308

Abnormal Stroop-related event

related potentials in patients with late

onset depression in remission period

M. Piˇsljar

1 ,

, Z. Pirtoˇsek

2

1

Psychiatric Hospital Idrija, Geriatric department, Idrija, Slovenia

2

University Medical Centre, Department of Neurology, Ljubljana,

Slovenia

Corresponding author.

Introduction

Depression in late life follows a relapsing course

and it has been related to impaired cognitive control. Informa-

tion processing speed, memory and executive abilities are most

frequently impaired.

Objectives

Cognitive changes are difficult to confirm during

depressive episode, as signs of both disorders largely overlap.

Therefore, it makesmore sense to assess cognition after a remission

has been reached. Electrophysiology may be particularly conve-

nient as a tool in such studies, as it can separate central cognitive

processing from the motor processing.

Aims

The study of cognition was focused on executive function

and speed of information processing. It was measured with Stroop-

related event related potentials (ERPs) and reaction times (RTs)

in a modified computer version of the Stroop test which is highly

sensitive to frontal functions.

Methods

Thirty-four patients with late-onset depression were

included after they had reached remission. They were compared

to twenty-four age-, gender- and education-matched healthy con-

trols. Each participant completed a single item computer version

of the Stroop task using verbal response mode. EEG and RT were

simultaneously recorded.

Results

Revealed abnormal late positive Stroop-related poten-

tials in the period of about 500–600ms period corresponding to

the latency of the so-called P300b wave.

Conclusion

Study supports the view that patients with late onset

depression are also cognitively impaired and that this impairment

persists in the period of early remission. Using more sensitive ERP

measurement of the Stroop task, we demonstrated impaired infor-

mation processing at an earlier, pre-response related stage.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.426

EW309

Cognitive screening in the acute

hospital: Preliminary findings from a

cognitive screening program in a

university-affiliated, tertiary-referral

hospital with 6-month interval

outcomes

C. Power

1 ,

, H. Bates

2

, M. Healy

2

, P. Gleeson

2

, E. Greene

2

1

St James’s Hospital, Memory Clinic- Mercer’s Institute for Research

in Ageing, Dublin, Ireland

2

St James’s Hospital, Psychiatry of the Elderly, Dublin, Ireland

Corresponding author.

Introduction

Cognitive impairment impacts on patient outcomes

[1] but is under-recognised in acute hospitals [2]. Data on rates and

degree of impairment among hospital inpatients remain sparse.

This information is vital for strategic planning of health services

as the European population ages.

Objectives

To examine the rates and degree of cognitive impair-

ment among patients aged 65 and older who were admitted to an

acute general hospital and to assess its impact on patient outcomes.

Methods

All patients aged over 65 who were admitted over a

2-week period were invited to participate. Those who met the

inclusion criteria were screened for delirium then underwent a

cognitive screening battery. Normative values for age and level of

education were obtained from the TILDA study [3]. Demographic

and outcome data were obtained from medical records.

Results

One hundred and forty-eight patients underwent cogni-

tive screening. Thirty-nine over 148 (26%) met the DSM-IV criteria

for dementia of whom only 16 (41%) had a previously-documented

impairment. Thirty over 148 (20%) had evidence of cognitive

impairment that did not meet criteria for dementia, only 3 (10%) of

whomwere previously documented. Seventy-three over 148 (49%)

were normal. Six over 148 (4%) were not classifiable. The impact of

cognitive status on length of hospital stay, number of readmissions

in 6 months and discharge destination was investigated. Impact on

length of stay was significant (

P

= 0.017) but significance was not

achieved against number of readmissions or discharge destination.

Conclusions

Cognitive impairment is pervasive and under-

recognised in the acute hospital and impacts on length of hospital

stay. Longer interval analysis is necessary to investigate further

implications.

References 1–3 available upon request.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.427

EW310

Clinical and cognitive outcome,

course of late onset depression –

A study from geriatric services of a

tertiary care center in India

S. Rajur

1 ,

, M. Varghese

1

, P.T. Sivakumar

1

, K.J. Kumar

2

1

National Institute of Mental Health & Neurosciences, Psychiatry,

Bangalore, India

2

National Institute of Mental Health & Neurosciences, Clinical

Psychology, Bangalore, India

Corresponding author.

Introduction

Literature on outcome studies of late onset depres-

sion (LOD) is inconsistent and long-term follow-up over LOD is

lacking from India.

Aims and objective

To study the course, outcome in LOD and to

compare the cognitive performance betweenpatientswith LODand

healthy controls.

Methodology

Study design was a naturalistic follow-up study.

Two hundred and ten case files of LOD between 2007 and 2012

were reviewed. Physical follow-up was done for fifty patients.

Depression was assessed using GDS and MADRS, follow-up data

using Longitudinal Interval Follow-up Evaluation (LIFE) and cogni-

tive functions using HMSE, neuropsychological battery for Indian

elderly, which was compared with matched healthy controls.

Results

Among 210 file reviews, 22.4% cases dropped out after

initial visit. Among 79 cases, where follow-up information was

available, 3 cases converted into BPAD, 1 had MCI and 1 of

them was converted to dementia who was missing. Thirty-three

were still symptomatic, 5 patients attained partial remission, 40

attained complete remission. Among 50 where in person evalu-

ation was done, only 28% of patients had regular follow-up and

66% had attained remission from index episode out of which

54% had at least one relapse at follow-up. Subjects in LOD group

had significantly inferior performance in Wordlist

{

IR (

P

< 0.001),

DR (

P

< 0.001)

}

, Design

{

Construction (

P

= 0.013), IR (

P

= 0.040), DR

(

P

= 0.014)

}

, DigitSpan

{

Forward (

P

= 0.014), Reverse (

P

= 0.012)

}

,

CorsiSpan

{

Forward (

P

= 0.011), Reverse(

P

= 0.039)

}

, Verbal fluency

total (

P

= 0.010) and Total time for Tower of Hanoi (

P

= 0.009).

However, remitted LOD patients performed better in executive

functions and memory.

Conclusion

Patients with LOD appear to have poorer outcome

with fewer remission rates, longer duration to achieve remission,

high probability of relapse and poorer performance in cognitive

functions.