European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348 S221
EW308
Abnormal Stroop-related event
related potentials in patients with late
onset depression in remission period
M. Piˇsljar ∗, Z. Pirtoˇsek
1 Psychiatric Hospital Idrija, Geriatric department, Idrija, Slovenia
2 University Medical Centre, Department of Neurology, Ljubljana,
Slovenia
∗ Corresponding author.
Introduction Depression in late life follows a relapsing course
and it has been related to impaired cognitive control. Informa-
tion processing speed, memory and executive abilities are most
frequently impaired.
Objectives Cognitive changes are difficult to confirm during
depressive episode, as signs of both disorders largely overlap.
Therefore, it makesmore sense to assess cognition after a remission
has been reached. Electrophysiology may be particularly conve-
nient as a tool in such studies, as it can separate central cognitive
processing from the motor processing.
Aims The study of cognition was focused on executive function
and speed of information processing. It was measured with Stroop-
related event related potentials (ERPs) and reaction times (RTs)
in a modified computer version of the Stroop test which is highly
sensitive to frontal functions.
Methods Thirty-four patients with late-onset depression were
included after they had reached remission. They were compared
to twenty-four age-, gender- and education-matched healthy con-
trols. Each participant completed a single item computer version
of the Stroop task using verbal response mode. EEG and RT were
simultaneously recorded.
Results Revealed abnormal late positive Stroop-related poten-
tials in the period of about 500–600ms period corresponding to
the latency of the so-called P300b wave.
Conclusion Study supports the view that patients with late onset
depression are also cognitively impaired and that this impairment
persists in the period of early remission. Using more sensitive ERP
measurement of the Stroop task, we demonstrated impaired infor-
mation processing at an earlier, pre-response related stage.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW309
Cognitive screening in the acute
hospital: Preliminary findings from a
cognitive screening program in a
university-affiliated, tertiary-referral
hospital with 6-month interval
outcomes
C. Power ∗, H. Bates , M. Healy , P. Gleeson , E. Greene
1 St James’s Hospital, Memory Clinic- Mercer’s Institute for Research
in Ageing, Dublin, Ireland
2 St James’s Hospital, Psychiatry of the Elderly, Dublin, Ireland
∗ Corresponding author.
Introduction Cognitive impairment impacts on patient outcomes
[1] but is under-recognised in acute hospitals [2]. Data on rates and
degree of impairment among hospital inpatients remain sparse.
This information is vital for strategic planning of health services
as the European population ages.
Objectives To examine the rates and degree of cognitive impair-
ment among patients aged 65 and older who were admitted to an
acute general hospital and to assess its impact on patient outcomes.
Methods All patients aged over 65 who were admitted over a
2-week period were invited to participate. Those who met the
inclusion criteria were screened for delirium then underwent a
cognitive screening battery. Normative values for age and level of
education were obtained from the TILDA study [3]. Demographic
and outcome data were obtained from medical records.
Results One hundred and forty-eight patients underwent cogni-
tive screening. Thirty-nine over 148 (26%) met the DSM-IV criteria
for dementia of whom only 16 (41%) had a previously-documented
impairment. Thirty over 148 (20%) had evidence of cognitive
impairment that did not meet criteria for dementia, only 3 (10%) of
whomwere previously documented. Seventy-three over 148 (49%)
were normal. Six over 148 (4%) were not classifiable. The impact of
cognitive status on length of hospital stay, number of readmissions
in 6 months and discharge destination was investigated. Impact on
length of stay was significant (P = 0.017) but significance was not
achieved against number of readmissions or discharge destination.
Conclusions Cognitive impairment is pervasive and under-
recognised in the acute hospital and impacts on length of hospital
stay. Longer interval analysis is necessary to investigate further
implications.
References 1–3 available upon request.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW310
Clinical and cognitive outcome,
course of late onset depression –
A study from geriatric services of a
tertiary care center in India
S. Rajur ∗, M. Varghese , P.T. Sivakumar , K.J. Kumar
1 National Institute of Mental Health & Neurosciences, Psychiatry,
Bangalore, India
2 National Institute of Mental Health & Neurosciences, Clinical
Psychology, Bangalore, India
∗ Corresponding author.
Introduction Literature on outcome studies of late onset depres-
sion (LOD) is inconsistent and long-term follow-up over LOD is
lacking from India.
Aims and objective To study the course, outcome in LOD and to
compare the cognitive performance betweenpatientswith LODand
healthy controls.
Methodology Study design was a naturalistic follow-up study.
Two hundred and ten case files of LOD between 2007 and 2012
were reviewed. Physical follow-up was done for fifty patients.
Depression was assessed using GDS and MADRS, follow-up data
using Longitudinal Interval Follow-up Evaluation (LIFE) and cogni-
tive functions using HMSE, neuropsychological battery for Indian
elderly, which was compared with matched healthy controls.
Results Among 210 file reviews, 22.4% cases dropped out after
initial visit. Among 79 cases, where follow-up information was
available, 3 cases converted into BPAD, 1 had MCI and 1 of
them was converted to dementia who was missing. Thirty-three
were still symptomatic, 5 patients attained partial remission, 40
attained complete remission. Among 50 where in person evalu-
ation was done, only 28% of patients had regular follow-up and
66% had attained remission from index episode out of which
54% had at least one relapse at follow-up. Subjects in LOD group
had significantly inferior performance in Wordlist {IR (P< 0.001),
DR (P < 0.001)}, Design {Construction (P = 0.013), IR (P = 0.040), DR
(P = 0.014)}, DigitSpan {Forward (P = 0.014), Reverse (P = 0.012)},
CorsiSpan {Forward (P = 0.011), Reverse( P = 0.039)}, Verbal fluency
total (P = 0.010) and Total time for Tower of Hanoi ( P= 0.009).
However, remitted LOD patients performed better in executive
functions and memory.
Conclusion Patients with LOD appear to have poorer outcome
with fewer remission rates, longer duration to achieve remission,
high probability of relapse and poorer performance in cognitive
functions.