European Psychiatry - Volume 33 - March 2016

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S216 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348
Background The ability to recognize facial emotion is consid-
ered as an important skill for social interaction. There is evidence
of impairments of this ability in psychiatric diseases such as
schizophrenia. The fact that this could be the same in bipolar disor-
der (BD) is controversial. Moreover, no studies address the impact
of aging on social cognition in BD.
Objective The main objective of this study was to evaluate facial
emotion recognition (FER) in euthymic elderly patients with BD
compared to healthy elderly volunteers. The secondary objective
was to search for correlations between FER, clinical and neurocog-
nitive features.
Methods Sixteen subjects with BD, in a euthymic state, with a
mean age of 73.94 years were included. They were assessed for FER
along with 16 healthy elderly volunteers. Neurocognitive abilities
were also assessed. A gender facial recognition task was used as
control.
Results BD patients had lower FER performance compared to
healthy controls, more specifically in fear, disgust and anger recog-
nition. No differencewas found for happiness or for the gender task.
Additionally, correlations were found between disgust, recognition
and certain executive function (EF) abilities.
Limitations The main limitation is the small size of the sample.
Also, we were not able to account for an influence of treatments.
Conclusions FER in BD seems to weaken with aging, especially for
negative emotions, maybe with an impact of EF decline. Longitu-
dinal studies with larger samples are required to investigate this
issue and to explore possible correlations with cognitive decline or
psychosocial functioning.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW294
Connection between cognitive
impairment and risk factors that can
be prevented
J. Jovi´c ∗ Iganjtovi´c-Risti´c isti´c istovi´c li´c
A. ´Corac
1 School of Medicine, University of Prishtina-Kosovska Mitrovica,
Department of Preventive Medicine, Kosovska Mitrovica, Serbia
2 Psychiatric clinic, Clinical Center “Kragujevac”, Psychiatry,
Kragujevac, Serbia
3 School of Medicine, University of Kragujevac, Psychiatry,
Kragujevac, Serbia
4 School of Medicine, University of Belgrade, Psychiatry, Beograd,
Serbia
5 The Public Health Institute of Uzice, Public Health, Uzice, Serbia
∗ Corresponding author.
Introduction Recent research in dementia was focused on deter-
mining risk factors that can be prevented. There is strong evidence
that these risk factors are: low levels of education, smoking, unreg-
ulated high blood pressure, blood sugar levels, blood lipid levels,
diabetes.
Objectives Following some of the risk factors for cognitive
impairment that can be prevented.
Aim Evaluating the connection between cognitive impairment
and education levels, blood glucose, cholesterol (chl) and triglyc-
eride (tgl) levels.
Methods Two hundred and thirty-seven subjects (162 women
and 75 men), with an average age of 80.75 ± 6.69 were included
in the research. Based on the MMSE score (single cutoff, < 24 is
abnormal), they were divided to a control group (without cognitive
impairment) and experimental group (with cognitive impairment).
We used Accu-Check Active appliance for determining blood levels
of tryglicerides, cholesterol and glucose.
Results Subjects in the experimental group were significantly
older (chi = 2.13, P < 0.01). Glucose levels were higher in the exper-
imental group but the difference was not statistically significant
(chi = 0.13, P = 0.56). Cholesterol and trygliceride levelswere signifi-
cantly higher in subjects with cognitive impairment (chl–chi = 3.56,
P < 0.05; tgl–chi = 8.78, P < 0.05). In the experimental group, there
was a statistically significant prevalence of subjects with less than
one year of education (chi = 13.8, P < 0.01).
Conclusion Confirming the connections between cognitive
impairment and education levels, glucose, cholesterol and
trygliceride blood levels can lead towards potential strategies for
prevention of those parameters. Even though our research con-
firmed the results from previous scientific studies, the connection
should be tested in future randomized controlled trial.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW295
Cognitive functions and magnetic
resonance imaging findings in
patients with late onset major
depression
O. Khalaf ∗, A.H. Hashem Hashem , M. Nasr El Din Sadek ,
A. Ismail Kamel , M. Al Adrousy Gomaa
1 Giza, Egypt
2 Faculty of Medicine, Cairo University, Psychiatry, Cairo, Egypt
3 Faculty of Medicine, Cairo University, Radiodiagnosis, Cairo, Egypt
∗ Corresponding author.
Background As many as three-quarters of patients with major
depressive disorder presenting to old age psychiatrists have late-
onset depression. Late-onset depression was conceptualized as
a neurologic disease and more often associated with cognitive
impairment than early-onset depression.
Objectives To compare cognitive functions between early-onset
(< 60 years) and late-onset ( ≥ 60 years) depression in geriatric
patients todetectwhitematter hyperintensities viaMRI usingmod-
ified Fazekas score.
Design A cross-sectional, comparative study with a consecutive
sample.
Subjects Eighty elderly patients with depression were recruited
from the Geriatric Outpatient Clinic-Psychiatry and Addiction Hos-
pital in Al Kasr Al-Ainy, Cairo University. They were divided
according to the age of onset of depression into 2 groups: Late onset
group (A) and Early onset group (B) depression, they were sub-
jected to the following: SCID-I, HDRS (Hamilton Depression Rating
Scale), BCRS (Brief Cognitive Rating Scale), GDS (Global deteriora-
tion Scale), ACE-R (Addenbrook’s Cognitive Examination-Revised),
Trail B Test, Digit symbol coding and Digit span subtest of Wechsler
Adult Intelligence Scale, MRI-Brain to assess white matter hyper-
intensities by using modified Fazekas rating.
Results Group A had worse performance than group B in trail
B test, total memory score, verbal fluency test, total language
score, visuospatial abilities, the total (ACE-R) and ischemic changes
periventricular and in deep white matter were more in group A
than in group B.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.