European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348 S209
Aims To investigate the associations among emotion dysregula-
tion dimensions and psychopathic traits, exploring similarities and
differences between the Interpersonal-Affective and the Antisocial-
Lifestyle facets of psychopathy.
Methods A sample of male offenders incarcerated in Italian jails
completed the Self-Report Psychopathy Scale (SRP-4; Paulhus,
Neumann, & Hare, 2015) and the Difficulties in Emotion Regulation
Scale (DERS; Gratz & Roemer, 2004).
Results In line with the expectations, emotion dysregulation
dimensions did predict higher levels of psychopathic traits. Struc-
tural Equation Modelling revealed that selected dimensions of
emotion dysregulationwere associatedwith different facets of psy-
chopathy.
Conclusions Based on our findings, we argue that psychopathic
traits may be associated to a certain extent with emotion dysreg-
ulation, and thus a focus on improving emotion regulation skills
may hold the promise to dampen the therapeutic pessimismwhen
dealing with psychopathic offenders.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW273
Lifetime abuse among male inmates
in an italian prison: Psychiatric
clinical correlates
N. Verdolini ∗, L. Attademo , R. Garinella , L. Pauselli ,
M. Piselli , P. Moretti , R. Qartesan
1 University of Perugia, School of Specialization in Psychiatry,
Department of Medicine, Perugia, Italy
2 University of Perugia, Section of Psychiatry, School of Specialization
in Psychiatry, Department of Medicine, Perugia, Italy
3 University of Perugia, Director of the School of Specialization in
Psychiatry, Section of Psychiatry, Department of Medicine, Perugia,
Italy
∗ Corresponding author.
Aim to evaluate the prevalence of lifetime abuse in inmates of
the Spoleto prison (Umbria, Italy) as well as the association with
psychiatric disorders, Axis I or II, lifetime drug abuse, self-harm in
the inmates and the history of legal problems or lifetime drug abuse
in their parents.
Subjects and methods Five hundred and twenty-six convicted
males incarcerated in the Spoleto Prison between October 2010
and September 2011 were evaluated by trained interviewers with
the SCID-I, the SCID-II, the ASI-X and the DSHI. Chi2 tests were
performed to examine the relation between the history of lifetime
abuse and the different clinical features.
Results Ninety-seven (18.4%) inmates reported a lifetime history
of abuse. Among them, 65 (67%) suffered from an Axis I diagno-
sis and 65 (67%) were given an Axis II diagnosis. Inmates that
reported a lifetime history of abuse were more likely to have an
Axis II diagnosis (P= .002) but not an Axis I diagnosis (P = 0.086) or
a lifetime drug abuse (P = 0.060) than those without abuse. Further-
more, there was a significant relationship between history of abuse
and lifetime self-harm in inmates (P< .001) and legal problems or
lifetime drug abuse in their parents (P < .001).
Conclusion Even though a lifetime history of abuse is not so
frequently reported in our sample of inmates, the high rates of psy-
chiatric disorders among those abused and the correlation with
self-harm should be taken in consideration when needs of inmates
are evaluated, mainly in those who require psychiatric treatments.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
Genetics & molecular neurobiology
EW274
Oxidative stress – A promising
candidate in explaining the
neurobiology of autism spectrum
disorders
M. Bækgaard Thorsen ∗, N. Bilenberg , E. Benedikz ,
Å. Fex Svenningsen , P. Munk-Jørgensen , T. Sheldrick-Michel
1 Psychiatric Hospital and University of Southern Denmark,
Psychiatric Research Academy Odense, Odense, Denmark
2 Psychiatric Hospital and University of Southern Denmark, Research
Unit of Psychiatry Odense, Odense, Denmark
3 Psychiatric Hospital and University of Southern Denmark, Research
Unit of Child, and Adolescent Psychiatry Odense, Odense, Denmark
4 Institute of Molecular Medicine, University of Southern Denmark,
Department of Neurobiology Research, Odense, Denmark
∗ Corresponding author.
Introduction The diagnoses of autism spectrum disorders (ASDs)
are based on a phenotype, characterized by impaired social interac-
tion and communication and by repetitive and restricted interests.
However, this might not represent a single clinical entity, but a
behavioral manifestation of different neurodevelopmental deficits
with a multifactorial etiology. Small studies have shown ele-
vated levels of oxidative stress and lower levels of anti-oxidants
in patients with ASD, and correlations with the severity of ASD.
Therapies targeting oxidative stress have shown improvements
regarding behavior, social interaction and verbal communication
in patients with ASD, supporting the oxidative stress theory.
Objectives To evaluate the importance of oxidative stress in the
neurobiology of adults with ASD.
Aims There is a need to understand the neurobiology of ASD,
therefore this study analyzes the level of oxidative stress in a larger
cohort of patients with ASD and compares to controls.
Methods The study includes 350 patients over 18 years of age
diagnosed with ICD-10 diagnoses F84.0, F84.1, F84.5 or F84.8 and
compared to gender and age matched neurotypical controls. The
included probands will have their serum and plasma analyzed for
levels of oxidative stress (superoxide dismutase 1 and 2, catalase,
glutathioneperoxidase, malonialdehyde, thiobarbituric acid reac-
tive substances and xanthinoxidase).
Results The preliminary results will be presented at the EPA in
March 2016 in Madrid.
Conclusion With this study we aim to elucidate some of the
neurobiology in ASD. This could lead to new potential targets for
treatment and prevention of the disorders.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW275
Plasma micro-RNA profiles in patients
with major depressive disorder (MDD)
V.R. Enatescu ∗, I. Papava , I. Enatescu , M. Antonescu ,
A. Anghel , E. Seclaman , I.O. Sirbu , R. Romosan , C. Marian
1 “Victor Babes” University of Medicine and Pharmacy Timisoara,
Department of Psychiatry, Timisoara, Romania
2 “Victor Babes” University of Medicine and Pharmacy Timisoara,
Department of Neonatology and Puericulture, Timisoara, Romania
3 “Victor Babes” University of Medicine and Pharmacy Timisoara,
Department of Biochemistry, Timisoara, Romania
∗ Corresponding author.
Introduction Micro-RNAs (miRs) are involved in processes
associated with MDD such as neural plasticity, neurogenesis,