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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

S209

Aims

To investigate the associations among emotion dysregula-

tion dimensions and psychopathic traits, exploring similarities and

differences between the Interpersonal-Affective and the Antisocial-

Lifestyle facets of psychopathy.

Methods

A sample of male offenders incarcerated in Italian jails

completed the Self-Report Psychopathy Scale (SRP-4; Paulhus,

Neumann, & Hare, 2015) and the Difficulties in Emotion Regulation

Scale (DERS; Gratz & Roemer, 2004).

Results

In line with the expectations, emotion dysregulation

dimensions did predict higher levels of psychopathic traits. Struc-

tural Equation Modelling revealed that selected dimensions of

emotion dysregulationwere associatedwith different facets of psy-

chopathy.

Conclusions

Based on our findings, we argue that psychopathic

traits may be associated to a certain extent with emotion dysreg-

ulation, and thus a focus on improving emotion regulation skills

may hold the promise to dampen the therapeutic pessimismwhen

dealing with psychopathic offenders.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.390

EW273

Lifetime abuse among male inmates

in an italian prison: Psychiatric

clinical correlates

N. Verdolini

1 ,

, L. Attademo

1

, R. Garinella

1

, L. Pauselli

1

,

M. Piselli

2

, P. Moretti

2

, R. Qartesan

3

1

University of Perugia, School of Specialization in Psychiatry,

Department of Medicine, Perugia, Italy

2

University of Perugia, Section of Psychiatry, School of Specialization

in Psychiatry, Department of Medicine, Perugia, Italy

3

University of Perugia, Director of the School of Specialization in

Psychiatry, Section of Psychiatry, Department of Medicine, Perugia,

Italy

Corresponding author.

Aim

to evaluate the prevalence of lifetime abuse in inmates of

the Spoleto prison (Umbria, Italy) as well as the association with

psychiatric disorders, Axis I or II, lifetime drug abuse, self-harm in

the inmates and the history of legal problems or lifetime drug abuse

in their parents.

Subjects and methods

Five hundred and twenty-six convicted

males incarcerated in the Spoleto Prison between October 2010

and September 2011 were evaluated by trained interviewers with

the SCID-I, the SCID-II, the ASI-X and the DSHI. Chi

2

tests were

performed to examine the relation between the history of lifetime

abuse and the different clinical features.

Results

Ninety-seven (18.4%) inmates reported a lifetime history

of abuse. Among them, 65 (67%) suffered from an Axis I diagno-

sis and 65 (67%) were given an Axis II diagnosis. Inmates that

reported a lifetime history of abuse were more likely to have an

Axis II diagnosis (

P

= .002) but not an Axis I diagnosis (

P

= 0.086) or

a lifetime drug abuse (

P

= 0.060) than those without abuse. Further-

more, there was a significant relationship between history of abuse

and lifetime self-harm in inmates (

P

< .001) and legal problems or

lifetime drug abuse in their parents (

P

< .001).

Conclusion

Even though a lifetime history of abuse is not so

frequently reported in our sample of inmates, the high rates of psy-

chiatric disorders among those abused and the correlation with

self-harm should be taken in consideration when needs of inmates

are evaluated, mainly in those who require psychiatric treatments.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.391

Genetics & molecular neurobiology

EW274

Oxidative stress – A promising

candidate in explaining the

neurobiology of autism spectrum

disorders

M. Bækgaard Thorsen

1 , 2 ,

, N. Bilenberg

3

, E. Benedikz

4

,

Å. Fex Svenningsen

4

, P. Munk-Jørgensen

1

, T. Sheldrick-Michel

2

1

Psychiatric Hospital and University of Southern Denmark,

Psychiatric Research Academy Odense, Odense, Denmark

2

Psychiatric Hospital and University of Southern Denmark, Research

Unit of Psychiatry Odense, Odense, Denmark

3

Psychiatric Hospital and University of Southern Denmark, Research

Unit of Child, and Adolescent Psychiatry Odense, Odense, Denmark

4

Institute of Molecular Medicine, University of Southern Denmark,

Department of Neurobiology Research, Odense, Denmark

Corresponding author.

Introduction

The diagnoses of autism spectrum disorders (ASDs)

are based on a phenotype, characterized by impaired social interac-

tion and communication and by repetitive and restricted interests.

However, this might not represent a single clinical entity, but a

behavioral manifestation of different neurodevelopmental deficits

with a multifactorial etiology. Small studies have shown ele-

vated levels of oxidative stress and lower levels of anti-oxidants

in patients with ASD, and correlations with the severity of ASD.

Therapies targeting oxidative stress have shown improvements

regarding behavior, social interaction and verbal communication

in patients with ASD, supporting the oxidative stress theory.

Objectives

To evaluate the importance of oxidative stress in the

neurobiology of adults with ASD.

Aims

There is a need to understand the neurobiology of ASD,

therefore this study analyzes the level of oxidative stress in a larger

cohort of patients with ASD and compares to controls.

Methods

The study includes 350 patients over 18 years of age

diagnosed with ICD-10 diagnoses F84.0, F84.1, F84.5 or F84.8 and

compared to gender and age matched neurotypical controls. The

included probands will have their serum and plasma analyzed for

levels of oxidative stress (superoxide dismutase 1 and 2, catalase,

glutathioneperoxidase, malonialdehyde, thiobarbituric acid reac-

tive substances and xanthinoxidase).

Results

The preliminary results will be presented at the EPA in

March 2016 in Madrid.

Conclusion

With this study we aim to elucidate some of the

neurobiology in ASD. This could lead to new potential targets for

treatment and prevention of the disorders.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.392

EW275

Plasma micro-RNA profiles in patients

with major depressive disorder (MDD)

V.R. Enatescu

1 ,

, I. Papava

1

, I. Enatescu

2

, M. Antonescu

3

,

A. Anghel

3

, E. Seclaman

3

, I.O. Sirbu

3

, R. Romosan

1

, C. Marian

3

1

“Victor Babes” University of Medicine and Pharmacy Timisoara,

Department of Psychiatry, Timisoara, Romania

2

“Victor Babes” University of Medicine and Pharmacy Timisoara,

Department of Neonatology and Puericulture, Timisoara, Romania

3

“Victor Babes” University of Medicine and Pharmacy Timisoara,

Department of Biochemistry, Timisoara, Romania

Corresponding author.

Introduction

Micro-RNAs (miRs) are involved in processes

associated with MDD such as neural plasticity, neurogenesis,