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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

S181

studies demonstrated a positive correlation between inflammatory

cytokines and suicidal behavior.

Conclusions

The mentioned association between inflammatory

cytokines, depression, and suicidal behavior does not imply the

existence of a causal relationship. Further additional studies should

clarify the molecular mechanisms of the immune activation path-

ways underlying depression and suicidality.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.311

EW194

N–methyl–D–aspartate antagonists in

depression–15 years after the first

ketamine clinical study what has

changed?

J. Ribeiro

, D. Mota , L. Rosa

Coimbra Hospital and University Centre, Psychiatry Department,

Coimbra, Portugal

Corresponding author.

Introduction

In the last decades, multiple studies have sug-

gested evidences of disturbances within the glutamate system

in depressed patients. The first clinical study using ketamine in

depression treatment was conduct fifteen years ago. Since then

several studies tried to understand the mechanisms underlying the

antidepressant effects of ketamine, as well as discover new drugs

with better pharmacodynamic profiles.

Objectives/aims

Review the literature on the role of gluta-

mate system in depression and novel approaches with glutamate

N–methyl–D–aspartate receptor antagonists in depression.

Methods

Search and review of scientific literature on PubMed

database with the keywords.

“major depressive disorder”, “depression”, “ketamine”, “gluta-

mate”, “NMDA”, “neuroplasticity”.

Results

Abnormalities of the glutamate clearance at synap-

tic space and astrocytic dysfunction associated with glutamate

metabolism have been associated with depressive symptomato-

logy. In depressed patients, reduced levels of glutamate have been

described by magnetic resonance spectroscopy in multiple cortical

areas, amygdala and hippocampus, supportting the hypothesis of

glutamate system involvement in the neurobiology of depression.

Indeed, in the last 15 years, multiple clinical studies using ketamine

provided some evidence that glutamate N–methyl–D–aspartate

receptor antagonism could be an approach for refractory forms

of depression. However, regardless all of the evidences, no drug

targeting specifically the glutamate system has been approved for

depression treatment.

Conclusions

The glutaminergic system plays a role in the patho-

physiology of depression, why it’s a possible therapeutic target. So,

it’s of utmost importance that future studies keep the focus in this

area, looking for new drugs active in this system.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.312

EW195

Disturbance of serum albumin

conformation in patients with

melancholic depression

M. Uzbekov

1 ,

, T. Syrejshchikova

2

, N. Smolina

3

, V. Brilliantova

1

,

G. Dobretsov

3

, V. Krujkov

4

, I. Emel’yanova

4

, V. Krasnov

4

1

Moscow Research Institute of Psychiatry, Brain Pathology, Moscow,

Russia

2

Lebedev Physical Institute, High energy, Moscow, Russia

3

Federal Research and Clinical Center of Physical-Chemical Medicine,

Biophysical methods of diagnostics, Moscow, Russia

4

Moscow Research Institute of Psychiatry, Affective disorders,

Moscow, Russia

Corresponding author.

Introduction

The last years it is became clear that disturbances in

molecular processes in pathological conditions can be connected

with conformational changes in protein structure.

Aim

Investigation of blood albumin conformation in patients

with melancholic depression.

Material and methods

There were investigated 19 patients with

melancholic depression (12 women and 7 men) and 25 health vol-

unteers. Patient’s state according to ICD-10 criteria was defined as a

depressive episode in the frame of bipolar depressive disorder (type

2) (F32) and in the structure of recurrent depressive disorder (F33).

Subnanosecond laser time resolved fluorescence spectroscopy

(SLTRFS) (subnanosecond diapason) with K-35 fluorescent probe

was used for the investigation of albumin conformation.

Results and discussion

There were revealed 3 binding sites in

albumin molecule with fluorescent decay time of 1, 3 and 9

nanoseconds (A1, A3 and A9 sites, respectively) in healthy vol-

unteers using SLTRFS approach. There were found significant

differences between albumin binding sites of volunteers and

patients with melancholic depression, respectively, A1–117

±

7

и

142

±

10; A3–358

±

14

и

420

±

26; A9–371

±

16

и

433

±

29.

Conclusion

These findings point out that melancholic depression

is followed by conformational changes of albumin molecule that

can affect its functional properties. We can hypothesized that albu-

min binding properties can serve as a biomarker of the efficacy of

psychopharmacotherapy.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.313

EW196

Differential profile amongst patients

with depressive disorder (DD) and

adjustment disorder (AD)

J. Martínez Arnaiz

1 ,

, B. Vallejo-Sánchez

1

, C. Garcia Blanco

1

,

A.M. Pérez-García

2

1

Santa Barbara Hospital, Mental Health Unit, Puertollano- Ciudad

Real, Spain

2

UNED, Psychology Faculty, Madrid, Spain

Corresponding author.

Introduction

Adjustment disorder (AD) is a condition that

includes both emotional or/and behavioral symptoms and occurs

when individual is unable to cope with stress. It is a common diag-

nosis but few studies have been done due to controversial diagnosis

related to their diagnostic criteria definition. It is often difficult to

establish differential diagnosis with condition such as depressive

and anxiety disorders or even normal reaction to stressful situa-

tions. There are limited tools to evaluate such condition and its

definition is focused or based on lack of severity.

Objectives

Study objective target is to analyse the differences

between two groups, a first group with AD and another one

with Major Depressive Disorder (MDD) (with different sociode-

mographic, clinical and triggering individual factors such as

vulnerability or copying management).

Aims

We try to have a better comprehension and management

of depressive conditions.

Methods

Two groups that belongs to Mental Health Commu-

nity Team are compared. The first one with a diagnosis of AD,

and another group with the diagnosis of MD. They have been

diagnosed through a structured clinical interview and standard

questionnaires to evaluate personality copyingmanagement. Other