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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

S187

EW212

Trauma, impulsiveness and

inflammatory dysfunction in eating

disorders

M. Diaz Marsá

1 ,

, A. Navalon

1

, A. Rodríguez Quiroga

2

,

K. MCDowell

3

, J.C. Leza

3

, M. Soto

4

, C. Prado

1

, J.L. Carrasco

1

1

Hospital Clinico San Carlos, Psychiatry, Madrid, Spain

2

Hospital Gregorio Mara˜nón, Psiquiatria, Madrid, Spain

3

Universidad Complutense De Madrid, Farmacología, Madrid, Spain

4

Hospital provincial de la Misericordia, Psiquiatria, Toledo, Spain

Corresponding author.

Introduction

Links between impulsiveness and eating disorders

(ED) is widely studied. The relationship between stress response

and inflammatory mechanisms in ED have also been suggested in

several studies.

Objectives

To clarify role of impulsivity in ED and to relate it with

inflammatory response observed in previous studies.

Methods

This study belongs to a larger one in which inflamma-

tory parameters inwhite blood cells were investigated in 50 female

patients with ED. Subjects were selected at the Eating Disorders

Unit of a general hospital. The psychopathology of the disorder was

evaluated by using different eating disorders assessment tools. A

neuropsychological battery test was also applied. In this study, we

used Barratt Impulsiveness Scale (BIS-11) to characterize impul-

siveness. We also divided sample in subgroups: impulsive ED and

non- impulsive ED in order to study differences in clinical variables

and inflammatory response between groups.

Results

A significant increase in plasma levels of the proin-

flammatory cytokine IL1b that correlates with scores in BIS-11

(Cognitive impulsiveness) was showed. We also found correlation

between psychoneurological test and inflammatory response. A

relationship between clinical assessment: trauma questionnaire

(TQ), and BIS-11 was also found. Subgroup impulsive ED had sig-

nificant higher scores in trauma than non impulsive ED.

Conclusions

Impulsiveness correlateswith greater dysfunction of

the inflammatory system. The increases in plasma levels of IL1b are

related to impulsive response, that indicates an inflammatory and

oxidative-nitrosative status in this particular clinical settings. This

study continued the investigation of a new line of inflammatory

biomarkers in patients with eating disorders.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.330

EW213

Emotional neglect as the colossus

among traumas in patients with

eating disorders. A case-control study

D. Piacentino

1 ,

, C. Loriedo

2

, M. Biondi

2

, P. Girardi

1

,

J. Vanderlinden

3

, A.M. Pignatelli

2

1

Sapienza - University of Rome, NESMOS Neuroscience- Mental

Health- and Sensory Organs Department, Rome, Italy

2

Sapienza - University of Rome, Department of Neurology and

Psychiatry, Rome, Italy

3

Catholic University of Leuven, Mind-Body-Unit- University

Psychiatric Center, Leuven, Belgium

Corresponding author.

Introduction

Individuals with eating disorders (EDs) often report

a history of early traumatization. Although a great attention has

been paid to sexual and physical trauma, less is known about emo-

tional one, especially neglect.

Objectives/aims

We aimed to estimate the prevalence of sexual,

physical, and emotional trauma–occurring under 18 years of age–in

ED patients vs. healthy controls, focusing on emotional abuse and

neglect.

Methods

We consecutively recruited 57 DSM-V ED outpatients

(91.2% females; age range = 18–42 years) at the Psychiatric Out-

patient Clinic of our University Hospital and 90 healthy controls

(78.9% females; age range = 20–39 years). Among EDpatients, 43.9%

had restrictive anorexia nervosa (AN), 29.8% binge/purging AN,

26.3% bulimia nervosa. Individuals completed the Eating Disorder

Inventory-2 (EDI-2) and the Traumatic Experiences Checklist (TEC).

We used Mann-Whitney U test and

2

test for comparisons.

Results

ED patients scored significantly higher than controls on

all EDI-2 subscales (

P

-values < 0.05). On the TEC, emotional trauma

was more frequent than sexual/physical ones in both ED patients

and controls. Emotional trauma, and to a lesser extent physical one,

were significantly more frequent in ED patients than controls. Dis-

tinguishing between emotional abuse and neglect, the latter had

a higher prevalence than the former in both groups. Additionally,

ED patients reported significantly more neglect, but not emotional

abuse, than controls.

Conclusions

Our findings show a high prevalence of emotional

trauma in EDs, mainly neglect, i.e., a lack of care and attention

potentially contributing to EDs. Thus, it is crucial to investigate

emotional neglect in ED patients.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.331

EW214

Severity of traumatic events in

patients with eating disorders. A

case-control study

A.M. Pignatelli

1 ,

, C. Loriedo

2

, M. Biondi

2

, P. Girardi

3

,

J. Vanderlinden

4

, D. Piacentino

3

1

Cisternino BR, Italy

2

Sapienza - University of Rome, Department of Neurology and

Psychiatry, Rome, Italy

3

Sapienza - University of Rome, NESMOS Neuroscience- Mental

Health- and Sensory Organs Department, Rome, Italy

4

Catholic University of Leuven, Mind-Body-Unit- University

Psychiatric Center, Leuven, Belgium

Corresponding author.

Introduction

A high proportion of individuals with eating disor-

ders (EDs) report childhood abuse and neglect. The prevalence of

traumatic events in ED patients has been extensively investigated;

less is known about their self-perceived–and reported–severity.

Objectives/Aims:We aimed to assess in EDpatients vs. healthy con-

trols the severity, i.e., duration, perpetrator, and subjective impact,

of sexual, physical, and emotional traumas suffered from 0 to 18

years, paying particular attention to emotional neglect.

Methods

Fifty-seven consecutive DSM-V ED patients (91.2%

females; age range: 18–42 years) were recruited at the Psychi-

atric Outpatient Clinic of our University Hospital. Ninety controls

(78.9% females; age range: 20–39 years)were also recruited. Among

ED patients, 43.9% had restrictive anorexia nervosa (AN), 29.8%

binge/purging AN, 26.3% bulimia nervosa. Individuals completed

the Eating Disorder Inventory-2 (EDI-2) and the Traumatic Experi-

ences Checklist (TEC).

Results

The severity of all traumatic events, according to the

TEC total score, was significantly higher in ED patients than con-

trols (

P

< 0.001). Moreover, ED patients showed significantly higher

scores with regard to emotional neglect (

P

< 0.001) and emo-

tional abuse (

P

< 0.001). The same can be said for physical traumas

(

P

< 0.01) and physical abuse (

P

< 0.01), although with a lower

significance, and for sexual abuse (

P

< 0.05), with an even lower sig-

nificance. No difference in the severity of sexual harassment was

found.

Conclusions

All types of traumas, especially neglect, can occur in

ED patients and controls, however they are reported asmore severe

by ED patients.