European Psychiatry - Volume 33 - March 2016

191 / 812

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348 S187
EW212
Trauma, impulsiveness and
inflammatory dysfunction in eating
disorders
M. Diaz Marsá ∗, A. Navalon , A. Rodríguez Quiroga ,
K. MCDowell , J.C. Leza , M. Soto , C. Prado , J.L. Carrasco
1 Hospital Clinico San Carlos, Psychiatry, Madrid, Spain
2 Hospital Gregorio Mara˜nón, Psiquiatria, Madrid, Spain
3 Universidad Complutense De Madrid, Farmacología, Madrid, Spain
4 Hospital provincial de la Misericordia, Psiquiatria, Toledo, Spain
∗ Corresponding author.
Introduction Links between impulsiveness and eating disorders
(ED) is widely studied. The relationship between stress response
and inflammatory mechanisms in ED have also been suggested in
several studies.
Objectives To clarify role of impulsivity in ED and to relate it with
inflammatory response observed in previous studies.
Methods This study belongs to a larger one in which inflamma-
tory parameters inwhite blood cells were investigated in 50 female
patients with ED. Subjects were selected at the Eating Disorders
Unit of a general hospital. The psychopathology of the disorder was
evaluated by using different eating disorders assessment tools. A
neuropsychological battery test was also applied. In this study, we
used Barratt Impulsiveness Scale (BIS-11) to characterize impul-
siveness. We also divided sample in subgroups: impulsive ED and
non- impulsive ED in order to study differences in clinical variables
and inflammatory response between groups.
Results A significant increase in plasma levels of the proin-
flammatory cytokine IL1b that correlates with scores in BIS-11
(Cognitive impulsiveness) was showed. We also found correlation
between psychoneurological test and inflammatory response. A
relationship between clinical assessment: trauma questionnaire
(TQ), and BIS-11 was also found. Subgroup impulsive ED had sig-
nificant higher scores in trauma than non impulsive ED.
Conclusions Impulsiveness correlateswith greater dysfunction of
the inflammatory system. The increases in plasma levels of IL1b are
related to impulsive response, that indicates an inflammatory and
oxidative-nitrosative status in this particular clinical settings. This
study continued the investigation of a new line of inflammatory
biomarkers in patients with eating disorders.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW213
Emotional neglect as the colossus
among traumas in patients with
eating disorders. A case-control study
D. Piacentino ∗, C. Loriedo , M. Biondi , P. Girardi ,
J. Vanderlinden , A.M. Pignatelli
1 Sapienza - University of Rome, NESMOS Neuroscience- Mental
Health- and Sensory Organs Department, Rome, Italy
2 Sapienza - University of Rome, Department of Neurology and
Psychiatry, Rome, Italy
3 Catholic University of Leuven, Mind-Body-Unit- University
Psychiatric Center, Leuven, Belgium
∗ Corresponding author.
Introduction Individuals with eating disorders (EDs) often report
a history of early traumatization. Although a great attention has
been paid to sexual and physical trauma, less is known about emo-
tional one, especially neglect.
Objectives/aims We aimed to estimate the prevalence of sexual,
physical, and emotional trauma–occurring under 18 years of age–in
ED patients vs. healthy controls, focusing on emotional abuse and
neglect.
Methods We consecutively recruited 57 DSM-V ED outpatients
(91.2% females; age range = 18–42 years) at the Psychiatric Out-
patient Clinic of our University Hospital and 90 healthy controls
(78.9% females; age range = 20–39 years). Among EDpatients, 43.9%
had restrictive anorexia nervosa (AN), 29.8% binge/purging AN,
26.3% bulimia nervosa. Individuals completed the Eating Disorder
Inventory-2 (EDI-2) and the Traumatic Experiences Checklist (TEC).
We used Mann-Whitney U test and 2 test for comparisons.
Results ED patients scored significantly higher than controls on
all EDI-2 subscales (P-values < 0.05). On the TEC, emotional trauma
was more frequent than sexual/physical ones in both ED patients
and controls. Emotional trauma, and to a lesser extent physical one,
were significantly more frequent in ED patients than controls. Dis-
tinguishing between emotional abuse and neglect, the latter had
a higher prevalence than the former in both groups. Additionally,
ED patients reported significantly more neglect, but not emotional
abuse, than controls.
Conclusions Our findings show a high prevalence of emotional
trauma in EDs, mainly neglect, i.e., a lack of care and attention
potentially contributing to EDs. Thus, it is crucial to investigate
emotional neglect in ED patients.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW214
Severity of traumatic events in
patients with eating disorders. A
case-control study
A.M. Pignatelli ∗, C. Loriedo , M. Biondi , P. Girardi ,
J. Vanderlinden , D. Piacentino
1 Cisternino BR, Italy
2 Sapienza - University of Rome, Department of Neurology and
Psychiatry, Rome, Italy
3 Sapienza - University of Rome, NESMOS Neuroscience- Mental
Health- and Sensory Organs Department, Rome, Italy
4 Catholic University of Leuven, Mind-Body-Unit- University
Psychiatric Center, Leuven, Belgium
∗ Corresponding author.
Introduction A high proportion of individuals with eating disor-
ders (EDs) report childhood abuse and neglect. The prevalence of
traumatic events in ED patients has been extensively investigated;
less is known about their self-perceived–and reported–severity.
Objectives/Aims:We aimed to assess in EDpatients vs. healthy con-
trols the severity, i.e., duration, perpetrator, and subjective impact,
of sexual, physical, and emotional traumas suffered from 0 to 18
years, paying particular attention to emotional neglect.
Methods Fifty-seven consecutive DSM-V ED patients (91.2%
females; age range: 18–42 years) were recruited at the Psychi-
atric Outpatient Clinic of our University Hospital. Ninety controls
(78.9% females; age range: 20–39 years)were also recruited. Among
ED patients, 43.9% had restrictive anorexia nervosa (AN), 29.8%
binge/purging AN, 26.3% bulimia nervosa. Individuals completed
the Eating Disorder Inventory-2 (EDI-2) and the Traumatic Experi-
ences Checklist (TEC).
Results The severity of all traumatic events, according to the
TEC total score, was significantly higher in ED patients than con-
trols (P < 0.001). Moreover, ED patients showed significantly higher
scores with regard to emotional neglect (P< 0.001) and emo-
tional abuse (P < 0.001). The same can be said for physical traumas
(P < 0.01) and physical abuse (P < 0.01), although with a lower
significance, and for sexual abuse (P < 0.05), with an even lower sig-
nificance. No difference in the severity of sexual harassment was
found.
Conclusions All types of traumas, especially neglect, can occur in
ED patients and controls, however they are reported asmore severe
by ED patients.