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S182

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

pathologies (such as psychotic, organic,

. . .

) were excluded through

a structured clinical interview. We analyzed variables considered

through variance analysis.

Results

Significant differences between groups were found in

some of the variables considered.

Conclusions

This study have important implications regarding

evaluation, differential diagnosis and psychotherapeutic approach

to patients with AD and MD.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.314

EW197

Use of GP services over a five-year

period after an episode of depression

P. Verhaak

University Medical Center Groningen, General Practice, Groningen,

Netherlands

Background

Depression occurs frequently and is mostly treated

in general practice. Little has been reported about its long-term

course and long-term use of medical services.

Aim

To follow up patients with these depression in general

practice for five years, looking at the length and number of index

episodes, prescribing behaviour and use of services within gen-

eral practice and compare them with patients with psychological

symptoms and mentally healthy patients.

Design and setting

A case-control study based on data from Elec-

tronic Medical Records (EMR).

Methods

Three cohorts of patients with depression (

n

= 453),

anxiety symptoms (

n

= 442) and emotional distress (

n

= 185) were

compared against a cohort of control patients (

n

= 4156) during a

5-year follow-up looking at the occurrence or recurrence of the

index disorders, other psychological disorders and medical disor-

ders, numbers of prescriptions and the number of contacts with the

general practice.

Results

The depression group had 1.1 follow-up episodes of

depression, the anxiety group 0.9 follow-up episodes of anxiety and

the emotional distress group 0.5 follow-up episodes of emotional

distress during five years. All three groups had more consultations

(for both psychological and somatic reasons) during each of the

follow-up years than control patients. Furthermore, they are given

more prescriptions for psychopharmacological treatment.

Conclusion

Five years after the index episode in 2007, patients

with an episode of depression, anxiety or emotional distress are

still not comparable with control patients, in terms of the preva-

lence of psychological disorders, the number of prescriptions and

healthcare use. Depression appears to be a chronic disease.

Disclosure of interest

The author has not supplied his/her decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.315

EW198

Anhedonic brain while attending

sexual and emotional pictures

F. Von Duering

Heiligenthal, Germany

Anhedonia is defined as the inability to gain pleasure from nor-

mally pleasurable experiences and reduced sexual desire. Rees et al.

(2007) showed that limbic and paralimbic areas are responsible for

sexual arousal and that anhedonia is associated with frontolim-

bic inhibition. In major depression, reduced ventral striatum and

increased ventral prefrontal cortex areas was associatedwith anhe-

donia(Gorwood, 2009). Walter et al. (2009) indicated that there is a

deviation in the neuronal activation pattern of the pregenual ante-

rior cingulate cortex in anhedonic depression which is related to

a glutamergic deficit. Glutamate was suggested to play a relevant

role in reward system (Birgner et al., 2005). ACC is a key involved

in affective state and glutamate mediates ACC activation to sex-

ual attraction(Wu et al., 2009). Thus, a glutamatergic deficit might

be related to reduced hedonic effect specific to major depression.

Using an attention modulation of emotional and sexual pictures,

we investigate the role of anhedonia on the ventral and dorsal sys-

tems in healthy volunteers and patients with major depression.

They undergo an expectancy task in a 7 T scanner and passively

view sexual and emotional photographs and are asked to expect

either high salient pictures or high erotic pictures. Half of these

pictures are announced by an expectancy cue, whereas the other

half are preceded by a fixation cross. Snaith-Hamilton-Pleasure-

Scale and Hamilton Depression Rating Scale are employed to assess

anhedonia and depressive symptom severity. Brain metabolites in

the dorsal and pgACC are measured using MRS. We will show how

anhedonia modulates the neural response to sexual arousal.

Disclosure of interest

The author has not supplied his/her decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.316

Eating disorders

EW199

Oxytocin secretion in anorexia

nervosa and bulimia nervosa:

Investigation of its relationships to

temperament personality dimensions

M. Nigro

1 ,

, A.M. Monteleone

1

, L. Steardo

1

, G. Patriciello

1

,

V. Di Maso

1

, M. Cimino

1

, U. Volpe

1

, P. Monteleone

2

1

Department of Psychiatry, University of Naples SUN- Naples- Italy,

Naples, Italy

2

University of Salerno, Neuroscience Section- Department of

Medicine and Surgery, Salerno, Italy

Corresponding author.

Introduction

Some temperament characteristics of personality

seem to be modulated by oxytocin. Patients suffering from eating

disorders (EDs) display aberrant personality traits.

Objectives and aims

We investigated the relationships between

plasma oxytocin levels and personality dimensions of patients with

anorexia nervosa (AN) and bulimia nervosa (BN) and compared

them to those of healthy controls.

Methods

Plasma oxytocin levels were measured in 23 women

with AN, 27 women with BN and 19 healthy controls and assessed

their personality traits by means of the Cloninger’s Temperament

and Character Inventory-Revised (TCI-R).

Results

AN patients showed plasma levels of the hormone sig-

nificantly lower than BN and healthy controls. In healthy women,

plasma oxytocin levels resulted significantly correlated negatively

with novelty seeking scores and positively with both harm avoid-

ance (HA) scores and the attachment subscale scores of the reward

dependence: these correlations explained 82% of the variability

in circulating oxytocin. In BN patients, plasma oxytocin resulted

negatively correlated with HA, whereas no significant correlations

emerged in AN patients.

Conclusions

These findings confirm a dysregulation of oxytocin

secretion in AN but not in BN and show, for the first time, that the

association of circulating oxytocin to patients’ temperament traits

is totally lost in underweight patients with AN and partially lost or

even inverted in women with BN. These findings suggest a role of

oxytocin in certain deranged behaviours of ED patients, which are

influenced by the subjects’ personality traits.