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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

S177

EW180

Maladaptive emotion regulation

mediating the link between the recall

of early affiliative memories and

depressive symptomatology

J. Marta-Simões , C. Ferreira

, A.L. Mendes , I.A. Trindade

Faculty of Psychology and Educational Sciences - University of

Coimbra, CINEICC - Cognitive Behavioural Centre for Research and

Intervention, Coimbra, Portugal

Corresponding author.

The inability of recalling warm and safe memories with parents

and close relatives has been often associated in literature with

a negative and judgmental sense of self, and a higher proneness

to experience feelings of inferiority, inadequacy, and defective-

ness. Thus, intending to deal with self-judgment and inferiority,

individuals may become submissive as a way of compensating

one’s negative emotional states with other’s positive attention and

desirability. However, both early negative affiliative memories and

submissiveness are associated with higher vulnerability to psy-

chopathology, namely depression. Using a sample of 338 young

women, the present study intended to examine the association

between early affiliative memories and depressive symptoma-

tology, and the mediator roles of self-judgment and submissive

attitudes and behaviours on this association, through a path anal-

ysis. The tested model provided an excellent fit to the data,

accounting for 41% of the depressive symptomatology’s vari-

ance. Results revealed a direct effect of early affiliative memories

on depressive symptomatology; and also on self-judgement and

submissiveness, explaining 28% and 23% of their variances, respec-

tively. Moreover, part of these memories’ effect on depressive

symptomatology was explained by self-judgment and submissive-

ness, which seems to suggest that submissiveness, although used

to compensate feelings of inferiority and a judging attitude towards

the self, may be a maladaptive strategy due to its positive associ-

ation with depressive symptoms. This study’s findings appear to

emphasize the relevance of targeting submissiveness, especially

in the context of a scarce recall of early affiliative experiences,

when approaching women’s depressive symptomatology on men-

tal health promotion programs.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.298

EW181

Monitoring of liver function in major

depressive disorder treated with SSRI

P. Ifteni

, A. Teodorescu

Spitalul de Psihiatrie si Neurologie, Psihiatrie Clinica III, Brasov,

Romania

Corresponding author.

Background

Major depressive disorder is one of the most preva-

lent psychiatric illnesses in the world affecting more than 12% of

men and more than 21% of women in their lifetime. Selective sero-

tonin reuptake inhibitors (SSRIs) are worldwide prescribed to treat

depression. SSRIs drugs can cause drug-induced liver injury (DILI).

Aims

The aim of the study was to evaluate the liver function in

patients treated with SSRI in order to detect DILI.

Methods

All the patients with first major depressive episode

treated with the same SSRI antidepressant for at least 3 months

between September 2013 and September 2015 were entered into

the study. The hepatic function panel included aminotransferases,

total and direct bilirubin, albumin, total protein, gamma glutamyl

transferase (GGT), LDH cholesterol, hepatitis B virus (HBV), and

hepatitis C virus (HCV).

Results

Of 134 subjects with MDD according to The Diagnostic

and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5)

whomet inclusion criteria, 98 patients entered into study. Seventy-

seven (76.5%) were treated with SSRI for at least 3 months with

mean age were 45.4 (SD = 6.3), 65 women (66.3%). Five patients

(5.1%) were newly diagnosed with hepatitis, and 10 (10.2%) pre-

sented elevated values of ALT, AST. Themean duration of depressive

symptoms was 9.2 months (SD = 6.9).

Conclusions

The treatment with SSRI seems to be effective and

safe in our sample. A relative small number of patients with MDD

were diagnosed with viral hepatitis during this cross-sectional

study. Further randomized and controlled trials are needed.

Keywords

Depression; Antidepressants; SSRI; Hepatitis

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.299

EW182

Biopsychosocial model of prevention

of depression

M. Khan

1 ,

, S. Asghar

2

, Z. Mukhtar

3

, S. Niaz

4

1

Lahor, Pakistan

2

Sexual Health Institute Pakistan, Psychology, Lahore, Pakistan

3

Azm center, Psychology, Sargodha, Pakistan

4

Chase form, Psychiatry, London, United Kingdom

Corresponding author.

Introdution

Depression is ranked third highest among disorders

responsible for global disease burden. Preventive strategies are

more cost effective than treatment alone. Depression is biological

disease having serious psychological and social consequences com-

prehensive program based on biopsychsocial model can curtail its

mortality and morbidity.

Method

Pubmed search was made to study about prevention of

depression.

Result

Different studies suggested food, exercise relaxation and

social support systemto prevent depression. At biological level food

is the first item. It should include omega 3, antioxidant, vitamin

D3, B6, B12, folic acid, fiber. Foods with anti inflammatory effects

too are recommended. Moderate exercise has biological effects

mediated by endorphins. It is advised to avoid proinflammatory

foods, refined sugar, smoking, and addiction. Whole some sexual

life has anti anxiety and antidepressant effects. At psychological

level high risk population is screened. Susceptible are taught cog-

nitive restructuring and coping strategies for stress. At social level

greater integration with family and friend can help the person.

Disscussion

Essential ingredients like omega 3 is derived from

fish, nuts seed oils. Fruit and vegetable and beans are rich in antiox-

idant, vitamins and fiber. Healthy food maintains hippocampal

volume, which gets shrunken by unhealthy food. Increased levels of

homocystine due to inflammation can decreasemonoamine neuro-

transmitters. Anti-inflammatory food include turmeric and garlic.

Sex increase blood levels of oxytocin during arousal dopamine sero-

tonin and endorphins at orgasm. Depression is less prevalent in

peaceful societies.

Conclusion

Every effort should be made to prevent depression.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.300

EW183

Escitalopram orally-disintegrating

tablets (ODT) in major depression

treatment

M. Polikowska , B. Łoza

Medical University of Warsaw, Psychiatry, Warsaw, Poland

Corresponding author.

Introduction

The growing rate of depressive disorders causes

needs for more effective and more innovative solutions. The