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S178

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

modern patients’ challenges make them fail mostly in the treat-

ment compliance. Some reports have described that escitalopram

orally disintegrating tablets (ODT) induce faster response and lower

dropout rate than oral standard tablets (OST), although both forms

have equal bioavailability.

Aim

We tried to clarify effectiveness rates between escitalopram

ODT and OST treatments in depressive patients.

Method

An open-label, 6-month, randomized, flexible-dose

study was conducted for direct comparison of the effects of esc-

italopram ODT (N16) and OST (N15) on dropout rate and clinical

outcomes in patients with major depression.

Results

Outcome measures included Hamilton Depression Rat-

ing Scale (HDRS), Drug Attitude Inventory-10 (DAI), Clinical Global

Improvement Scale (CGI), and Psychological General Well-Being

Scale (PGWB). The tolerability was assessed by the UKU scale. No

significant difference was found in HDRS, CGI, PGWB and GAF

between the two forms of tablets. No significant difference was

found in any tolerability rates. However, dropout rate favored esc-

italopram ODT group (N5, 31.3%) vs escitalopram OST (N7, 47.0%).

DAI-10 outcomes, both in patients’ general attitude and subjec-

tive feelings, were significantly improved in ODT group (

P

= 0.000),

comparing with OST.

Discussion

Escitalopram in its classical form (OST) has become a

leader in a group of antidepressants, thanks to safety of use, efficacy

and tolerability. In the ODT form, escitalopram can meet additional

needs, both clinical and lifestyle. ODT may reduce dropout rate and

costs of long-term treatment improving the patients’ compliance.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.301

EW184

Psychosocial and clinical

characteristics of depressed patients

with metabolic syndrome

M. Martina

c 1 ,

, D .

Babi´c

2 , M.

Pavlovi´c

2

1

Public Health Centre Mostar, Centre for Mental Health, Mostar,

Bosnia and Herzegovina

2

University Clinical Hospital Mostar, Department of Psychiatry,

Mostar, Bosnia and Herzegovina

Corresponding author.

Introduction

Depression is a complex disease associated with

sleep, appetite and body weight disturbances as well as with the

level of physical activity, all of which may be the risk factors for the

development of metabolic disorders. Different physiological mech-

anisms as well as psychosocial factors such as gender, age, smoking,

stress level, nutrition and level of physical activity can affect the

metabolic syndrome (MS) development in depressed patients. It is

considered that chronic stress causes depression and subsequent

poor lifestyle that can lead to the MS development, which results

in increased incidence of cardiovascular disease.

Aim

To determine the psychosocial and clinical characteristics of

depressed patients with MS diagnosis.

Methods

Cross-sectional study was conducted on a sample of 80

patients suffering from depressive disorder. The structured socio-

demographic questionnaire, MINI questionnaire, Hamilton Rating

Scale for Depression (HAMD-17) and the Clinical Global Impression

Scale (CGI) were used as diagnostic instruments. MS diagnosis was

made according to NCEP/ATP III criteria.

Results

Depressive patients withMS diagnosis had a significantly

higher frequency of suicide attempts, while MS diagnosis signifi-

cantly more frequently was present in female patients. Increased

intake of carbohydrates was an important characteristic of the

depression as well as MS.

Conclusion

Further studies are needed in order to explain the

observed gender differences, and whether interventions focused

on the treatment of depression may contribute to the acceptance

of healthy lifestyles, particularly in changing of dietary habits, and

thus indirectly contribute to the reduction of MS frequency.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.302

EW185

Self-esteem and emotional distress in

a population of unemployed persons

K. Medhaffar

, I. F

eki , R. Sellami , I. Baati , D. Trigui , I. Abida ,

J. Masmoudi

Hédi Chaker University Hospital, Psychiatry “A”, Sfax, Tunisia

Corresponding author.

Introduction

For most individuals, basic life requirements are

met through employment. It can satisfy creative urges, promote

self-esteem, and provide an avenue for achievement and self-

realization.

Objective

To assess the level of depression, anxiety and self-

esteem in a population of unemployed persons.

Method

It was a cross-sectional study involving unemployed

people we met in the office of employment of Sfax in Tunisia. The

level of anxiety and depressionwas assessed by the Beck depression

and anxiety inventories. The self-esteem Rosenberg scale allowed

us to evaluate the level of self-esteem of our population.

Results

The average age of oursubjects was 33 years six months.

The average duration of unemployment of our population was 4

years 7 months and 38.2% of them had never worked before. The

anxiety level was moderate in 38.2%, while moderate to severe

depression was found in 47%. Self-esteem was low to very low in

47.1%. A low level of depressionwas positively correlatedwith a low

socioeconomic level (

P

= 0.000), a low level of anxiety (

P

= 0.000)

and a high self-esteem level (

P

= 0.000).

Conclusion

People with strong support systems and greater

self-esteem seemed to experience less unemployment stress. Iden-

tifying those who are at high risk for psychological and physical

problems and finding ways of preventing them from suffering the

adverse effect of unemployment are important areas for further

study.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.303

EW186

Religion and depression among

Iranian college students

M.M. Naderi

Islamic Azad University- Azadshar Branch- IRAN, Psychology,

Azadshahr, Iran

Objective

The main aim of the present study is to investigate the

relationship between religious attitudes and depression.

Method

The statistical sample of this study is 129 students of

Islamic Azad university Azadshahr branch selected randomly sub-

jects have been asked to fill out the beck depression Inventory

(1978) and religious Attitude Questionnaire (Serahzade, 1978).

Pearson correlation coefficient and Multiple factor regression have

been used to analyze the research hypothesis.

Results

The findings suggested that there is significant relation-

ship between depression and religious attitudes. Furthermore,

religious attitudes could explain the depression variance signifi-

cantly.

Conclusion

Religion plays a major role in human life and mental

health.

Disclosure of interest

The author has not supplied his/her decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.304