European Psychiatry - Volume 33 - March 2016

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S178 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348
modern patients’ challenges make them fail mostly in the treat-
ment compliance. Some reports have described that escitalopram
orally disintegrating tablets (ODT) induce faster response and lower
dropout rate than oral standard tablets (OST), although both forms
have equal bioavailability.
Aim We tried to clarify effectiveness rates between escitalopram
ODT and OST treatments in depressive patients.
Method An open-label, 6-month, randomized, flexible-dose
study was conducted for direct comparison of the effects of esc-
italopram ODT (N16) and OST (N15) on dropout rate and clinical
outcomes in patients with major depression.
Results Outcome measures included Hamilton Depression Rat-
ing Scale (HDRS), Drug Attitude Inventory-10 (DAI), Clinical Global
Improvement Scale (CGI), and Psychological General Well-Being
Scale (PGWB). The tolerability was assessed by the UKU scale. No
significant difference was found in HDRS, CGI, PGWB and GAF
between the two forms of tablets. No significant difference was
found in any tolerability rates. However, dropout rate favored esc-
italopram ODT group (N5, 31.3%) vs escitalopram OST (N7, 47.0%).
DAI-10 outcomes, both in patients’ general attitude and subjec-
tive feelings, were significantly improved in ODT group (P = 0.000),
comparing with OST.
Discussion Escitalopram in its classical form (OST) has become a
leader in a group of antidepressants, thanks to safety of use, efficacy
and tolerability. In the ODT form, escitalopram can meet additional
needs, both clinical and lifestyle. ODT may reduce dropout rate and
costs of long-term treatment improving the patients’ compliance.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW184
Psychosocial and clinical
characteristics of depressed patients
with metabolic syndrome
M. Martina ∗ Babi´c Pavlovi´c
1 Public Health Centre Mostar, Centre for Mental Health, Mostar,
Bosnia and Herzegovina
2 University Clinical Hospital Mostar, Department of Psychiatry,
Mostar, Bosnia and Herzegovina
∗ Corresponding author.
Introduction Depression is a complex disease associated with
sleep, appetite and body weight disturbances as well as with the
level of physical activity, all of which may be the risk factors for the
development of metabolic disorders. Different physiological mech-
anisms as well as psychosocial factors such as gender, age, smoking,
stress level, nutrition and level of physical activity can affect the
metabolic syndrome (MS) development in depressed patients. It is
considered that chronic stress causes depression and subsequent
poor lifestyle that can lead to the MS development, which results
in increased incidence of cardiovascular disease.
Aim To determine the psychosocial and clinical characteristics of
depressed patients with MS diagnosis.
Methods Cross-sectional study was conducted on a sample of 80
patients suffering from depressive disorder. The structured socio-
demographic questionnaire, MINI questionnaire, Hamilton Rating
Scale for Depression (HAMD-17) and the Clinical Global Impression
Scale (CGI) were used as diagnostic instruments. MS diagnosis was
made according to NCEP/ATP III criteria.
Results Depressive patients withMS diagnosis had a significantly
higher frequency of suicide attempts, while MS diagnosis signifi-
cantly more frequently was present in female patients. Increased
intake of carbohydrates was an important characteristic of the
depression as well as MS.
Conclusion Further studies are needed in order to explain the
observed gender differences, and whether interventions focused
on the treatment of depression may contribute to the acceptance
of healthy lifestyles, particularly in changing of dietary habits, and
thus indirectly contribute to the reduction of MS frequency.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW185
Self-esteem and emotional distress in
a population of unemployed persons
K. Medhaffar ∗ eki , R. Sellami , I. Baati , D. Trigui , I. Abida ,
J. Masmoudi
Hédi Chaker University Hospital, Psychiatry “A”, Sfax, Tunisia
∗ Corresponding author.
Introduction For most individuals, basic life requirements are
met through employment. It can satisfy creative urges, promote
self-esteem, and provide an avenue for achievement and self-
realization.
Objective To assess the level of depression, anxiety and self-
esteem in a population of unemployed persons.
Method It was a cross-sectional study involving unemployed
people we met in the office of employment of Sfax in Tunisia. The
level of anxiety and depressionwas assessed by the Beck depression
and anxiety inventories. The self-esteem Rosenberg scale allowed
us to evaluate the level of self-esteem of our population.
Results The average age of oursubjects was 33 years six months.
The average duration of unemployment of our population was 4
years 7 months and 38.2% of them had never worked before. The
anxiety level was moderate in 38.2%, while moderate to severe
depression was found in 47%. Self-esteem was low to very low in
47.1%. A low level of depressionwas positively correlatedwith a low
socioeconomic level (P = 0.000), a low level of anxiety (P = 0.000)
and a high self-esteem level (P = 0.000).
Conclusion People with strong support systems and greater
self-esteem seemed to experience less unemployment stress. Iden-
tifying those who are at high risk for psychological and physical
problems and finding ways of preventing them from suffering the
adverse effect of unemployment are important areas for further
study.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW186
Religion and depression among
Iranian college students
M.M. Naderi
Islamic Azad University- Azadshar Branch- IRAN, Psychology,
Azadshahr, Iran
Objective The main aim of the present study is to investigate the
relationship between religious attitudes and depression.
Method The statistical sample of this study is 129 students of
Islamic Azad university Azadshahr branch selected randomly sub-
jects have been asked to fill out the beck depression Inventory
(1978) and religious Attitude Questionnaire (Serahzade, 1978).
Pearson correlation coefficient and Multiple factor regression have
been used to analyze the research hypothesis.
Results The findings suggested that there is significant relation-
ship between depression and religious attitudes. Furthermore,
religious attitudes could explain the depression variance signifi-
cantly.
Conclusion Religion plays a major role in human life and mental
health.
Disclosure of interest The author has not supplied his/her decla-
ration of competing interest.