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S162

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

the Asthma Control Test (ACT). Alexithymia was measured using

Toronto Alexithymia Scale (TAS 20).

Results

Themean agewas 51 ans. Sex-ratio F/Mwas 14. Themean

duration of disease was 11 years. Long-term control medicines

were: inhaled corticosteroids, long-acting beta agonists and the-

ophylline respectively in 86.7%, 33.3% and 26.7%. Two thirds of our

patients had a bad therapeutic adherence. The average ACT score

was 16.8 points. Asthma was uncontrolled in 1/3 and well con-

trolled in 1/3 of cases. The average TAS 20 score was 64.8 points.

Twenty percent of patients were non-alexithymic, 13.3% had a

probable alexithymia and 66.7% were alexithymic. This score was

positively correlated to bad asthma control (

P

< 0.001), long term

evolution (

P

= 0.002) and use of inhaled corticoids (

P

< 0.001). It was

inversely correlated to ACT score (

P

< 0.001).

Conclusion

Our study shows the high prevalence of alexithymia

in patients with asthma and its negative impact in asthma control.

Psychological support aiming specifically alexithymic dimension in

these patients is indispensable.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.252

EW135

Developmental coordination disorder

(DCD), an umbrella term for motor

dysfunctions, which could associate

minor neurological dysfunctions

L. Vaivre-Douret

1 ,

, C. Lalanne

2

, B. Golse

3

1

University of Paris Descartes, Sorbonne Paris City, Department of

Medicine, Necker–Enfants-Malades University Hospital, Child

psychiatry, Imagine affiliation, INSERM Unit 1178 and CESP Paris

Sud, UVSQ, Paris-Saclay university, and Department of Pediatrics,

Child development, Cochin-Port Royal University Hospitals of Paris

Center, Assistance publique–Hôpitaux de Paris, Paris, France

2

University of Paris Diderot, Paris Sorbonne City, EA 7334 REMES,

Patient-Centered Outcomes Research, Paris, France

3

University of Paris Descartes, Sorbonne Paris City, Department of

Medicine, Necker-Enfants Malades University Hospital, Child

psychiatry, INSERM Unit 1178 and CESP Paris Sud, UVSQ,

Paris-Saclay university, Paris, France

Corresponding author.

Introduction

Developmental Coordination Disorder (DCD)

defines a heterogeneous class of children exhibiting marked

impairment in motor coordination.

Objectives

Explore in depth a general group of deficits in fine and

grossmotricity (subtypemixed group) common to all research sub-

typing studies. We aimed to highlight discriminant features and

specific comorbidities.

Methods

Data from DCD children aged between 6 and 13 years

were eligible for inclusion in this study on DSM-5 criteria. All

children were assessed with a neuropsychological evaluation of

all brain functions and with developmental standardized physical

tasks in the neuropsychomotor battery (NP-MOT) which include

detection of minor neurological dysfunction (MND) and neurolog-

ical soft signs (NSS) using tone examination, never considered in

most previous studies.

Results

Findings show in an unexpected way, a high incidence, in

33% of the children, of a motor pathway dysfunction, evidenced by

mild spasticity of gastrocnemiusmuscles in the lower limbs, associ-

ated with NSS, for instance failure of standing tone (

P

= 0.004) and

dysdiadochokinesia (

P

= 0.011) versus salient DCD markers of the

mixed subtype as imitation of gestures, fingers digital perception,

digital praxia, manual dexterity, and upper and lower limbs coordi-

nation. This mild spasticity (MND) appears as a comorbid disorder

increasing impairment of coordination between upper and lower

limbs and manual dexterity. It could explain why DCD appears

as a collection of motor disorders in a heterogeneous groups in

numerous studies.

Conclusions

Our results provide important new evidence to

implement an extensive neuro-developmental assessment (men-

tal and physical), including neuromuscular tone examination

using appropriate standardized neurodevelopmental tools (com-

mon tasks across ages).

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.253

EW136

Psychiatric comorbidity does not only

depend on diagnostic thresholds: An

illustration with major depressive

disorder and generalized anxiety

disorder

H. van Loo

1 ,

, R. Schoevers

1

, K. Kendler

2

, P. de Jonge

1

,

J.W. Romeijn

3

1

University Medical Center Groningen, Psychiatry, Groningen,

Netherlands

2

Virginia Commonwealth University, Virginia Institute of Psychiatric

and Behavioral Genetics, Richmond, USA

3

University of Groningen, Faculty of Philosophy, Groningen,

Netherlands

Corresponding author.

Background

High rates of psychiatric comorbidity are subject of

debate: to what extent do they depend on classification choices

such as diagnostic thresholds?

Aims/objectives

To investigate the influence of different thresh-

olds on rates of comorbidity between major depressive disorder

(MDD) and generalized anxiety disorder (GAD).

Methods

Point prevalence of comorbidity between MDD and

GADwas measured in 74,092 subjects from the general population

according to DSM-IV-TR criteria. Comorbidity rates were compared

for different thresholds by varying the number of necessary criteria

from

1 to all 9 symptoms forMDD, and from

1 to all 7 symptoms

for GAD.

Results

According toDSM-thresholds, 0.86%hadMDDonly, 2.96%

GAD only and 1.14% both MDD and GAD (Odds Ratio [OR] 42.6).

Lower thresholds for MDD led to higher rates of comorbidity (1.44%

for

4 of 9 MDD-symptoms, OR 34.4), whereas lower thresh-

olds for GAD hardly influenced comorbidity (1.16% for

3 of 7

GAD-symptoms, OR 38.8). Specific patterns in the distribution of

symptoms within the population explained this finding: 37.3% of

subjects with core criteria of MDD and GAD reported subthreshold

MDD symptoms, whereas only 7.6% reported subthreshold GAD

symptoms.

Conclusions

Lower thresholds for MDD increased comorbidity

with GAD, but not vice versa, owing to specific symptom patterns

in the population. Generally, comorbidity rates result from both

empirical symptom distributions and classification choices and

cannot be reduced to either of these exclusively. This insight invites

further research into the formation of disease concepts that allow

for reliable predictions and targeted therapeutic interventions.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.254