European Psychiatry - Volume 33 - March 2016

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S162 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348
the Asthma Control Test (ACT). Alexithymia was measured using
Toronto Alexithymia Scale (TAS 20).
Results Themean agewas 51 ans. Sex-ratio F/Mwas 14. Themean
duration of disease was 11 years. Long-term control medicines
were: inhaled corticosteroids, long-acting beta agonists and the-
ophylline respectively in 86.7%, 33.3% and 26.7%. Two thirds of our
patients had a bad therapeutic adherence. The average ACT score
was 16.8 points. Asthma was uncontrolled in 1/3 and well con-
trolled in 1/3 of cases. The average TAS 20 score was 64.8 points.
Twenty percent of patients were non-alexithymic, 13.3% had a
probable alexithymia and 66.7% were alexithymic. This score was
positively correlated to bad asthma control (P < 0.001), long term
evolution (P = 0.002) and use of inhaled corticoids (P < 0.001). It was
inversely correlated to ACT score (P< 0.001).
Conclusion Our study shows the high prevalence of alexithymia
in patients with asthma and its negative impact in asthma control.
Psychological support aiming specifically alexithymic dimension in
these patients is indispensable.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW135
Developmental coordination disorder
(DCD), an umbrella term for motor
dysfunctions, which could associate
minor neurological dysfunctions
L. Vaivre-Douret ∗, C. Lalanne , B. Golse
1 University of Paris Descartes, Sorbonne Paris City, Department of
Medicine, Necker–Enfants-Malades University Hospital, Child
psychiatry, Imagine affiliation, INSERM Unit 1178 and CESP Paris
Sud, UVSQ, Paris-Saclay university, and Department of Pediatrics,
Child development, Cochin-Port Royal University Hospitals of Paris
Center, Assistance publique–Hôpitaux de Paris, Paris, France
2 University of Paris Diderot, Paris Sorbonne City, EA 7334 REMES,
Patient-Centered Outcomes Research, Paris, France
3 University of Paris Descartes, Sorbonne Paris City, Department of
Medicine, Necker-Enfants Malades University Hospital, Child
psychiatry, INSERM Unit 1178 and CESP Paris Sud, UVSQ,
Paris-Saclay university, Paris, France
∗ Corresponding author.
Introduction Developmental Coordination Disorder (DCD)
defines a heterogeneous class of children exhibiting marked
impairment in motor coordination.
Objectives Explore in depth a general group of deficits in fine and
grossmotricity (subtypemixed group) common to all research sub-
typing studies. We aimed to highlight discriminant features and
specific comorbidities.
Methods Data from DCD children aged between 6 and 13 years
were eligible for inclusion in this study on DSM-5 criteria. All
children were assessed with a neuropsychological evaluation of
all brain functions and with developmental standardized physical
tasks in the neuropsychomotor battery (NP-MOT) which include
detection of minor neurological dysfunction (MND) and neurolog-
ical soft signs (NSS) using tone examination, never considered in
most previous studies.
Results Findings show in an unexpected way, a high incidence, in
33% of the children, of a motor pathway dysfunction, evidenced by
mild spasticity of gastrocnemiusmuscles in the lower limbs, associ-
ated with NSS, for instance failure of standing tone (P = 0.004) and
dysdiadochokinesia (P = 0.011) versus salient DCD markers of the
mixed subtype as imitation of gestures, fingers digital perception,
digital praxia, manual dexterity, and upper and lower limbs coordi-
nation. This mild spasticity (MND) appears as a comorbid disorder
increasing impairment of coordination between upper and lower
limbs and manual dexterity. It could explain why DCD appears
as a collection of motor disorders in a heterogeneous groups in
numerous studies.
Conclusions Our results provide important new evidence to
implement an extensive neuro-developmental assessment (men-
tal and physical), including neuromuscular tone examination
using appropriate standardized neurodevelopmental tools (com-
mon tasks across ages).
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW136
Psychiatric comorbidity does not only
depend on diagnostic thresholds: An
illustration with major depressive
disorder and generalized anxiety
disorder
H. van Loo ∗, R. Schoevers , K. Kendler , P. de Jonge ,
J.W. Romeijn
1 University Medical Center Groningen, Psychiatry, Groningen,
Netherlands
2 Virginia Commonwealth University, Virginia Institute of Psychiatric
and Behavioral Genetics, Richmond, USA
3 University of Groningen, Faculty of Philosophy, Groningen,
Netherlands
∗ Corresponding author.
Background High rates of psychiatric comorbidity are subject of
debate: to what extent do they depend on classification choices
such as diagnostic thresholds?
Aims/objectives To investigate the influence of different thresh-
olds on rates of comorbidity between major depressive disorder
(MDD) and generalized anxiety disorder (GAD).
Methods Point prevalence of comorbidity between MDD and
GADwas measured in 74,092 subjects from the general population
according to DSM-IV-TR criteria. Comorbidity rates were compared
for different thresholds by varying the number of necessary criteria
from ≥ 1 to all 9 symptoms forMDD, and from ≥ 1 to all 7 symptoms
for GAD.
Results According toDSM-thresholds, 0.86%hadMDDonly, 2.96%
GAD only and 1.14% both MDD and GAD (Odds Ratio [OR] 42.6).
Lower thresholds for MDD led to higher rates of comorbidity (1.44%
for ≥ 4 of 9 MDD-symptoms, OR 34.4), whereas lower thresh-
olds for GAD hardly influenced comorbidity (1.16% for≥ 3 of 7
GAD-symptoms, OR 38.8). Specific patterns in the distribution of
symptoms within the population explained this finding: 37.3% of
subjects with core criteria of MDD and GAD reported subthreshold
MDD symptoms, whereas only 7.6% reported subthreshold GAD
symptoms.
Conclusions Lower thresholds for MDD increased comorbidity
with GAD, but not vice versa, owing to specific symptom patterns
in the population. Generally, comorbidity rates result from both
empirical symptom distributions and classification choices and
cannot be reduced to either of these exclusively. This insight invites
further research into the formation of disease concepts that allow
for reliable predictions and targeted therapeutic interventions.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.