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S168

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

3

University of Limerick, Graduate Entry Medical School, Limerick,

Ireland

Corresponding author.

Introduction

Traditionally psychomotor subtypes have been

investigated in patients with delirium in different settings and it

has been found that those with hypoactive type is the largest pro-

portion, often missed and with the worst outcomes.

Aims and objectives

We examined the psychomotor subtypes in

an older age inpatients population, the effects that observed clinical

variables have on psychomotor subtypes and their associationwith

one year mortality.

Methods

Prospective study. Participants were assessed using the

scales CAM, APACHE II, MoCA, Barthel Index and DRS-R98. Pre-

existing dementia was diagnosed according to DSM-IV criteria.

Psychomotor subtypeswere evaluatedusing the two relevant items

of DRS-R98. Mortality rates were investigated one year after admis-

sion day.

Results

The sample consisted of 200 participants [mean age

81.1

±

6.5; 50% female; pre-existing cognitive impairment in 126

(63%)]. Thirty-four (17%) were identified with delirium (CAM+).

Motor subtypes of the entire sample was: none: 119 (59.5%), hypo:

37 (18.5%), mixed: 15 (7.5%) and hyper: 29 (14.5%). Hypoactive

and mixed subtype were significantly more frequent to delirious

patients than to those without delirium, and none subtype more

often to those without delirium. There was no difference in the

hyperactive subtype between those with and without delirium.

Hypoactive subtype was significant associated with delirium and

lower scores in MoCA (cognition), while mixed was associated

mainly with delirium. Predictors for one-year mortality were lower

MoCA scores and severity of illness.

Conclusions

Psychomotor disturbances are not unique to delir-

ium. Hypoactivity, this “silent epidemic” is also part of a

deteriorated cognition.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.270

EW153

Use of antipsychotics and

antidepressants in patients with HIV

P. Mu˜noz-Calero

, F. García Sánchez , N. Rodriguez Criado ,

R. Martín Aragón , J.F. Cruz Fourcade , S. Bravo Herrero ,

B. Sánchez Sánchez

Hospital Universitario de Móstoles, Psychiatry, Móstoles, Spain

Corresponding author.

Introduction

Psychological distress appears in the majority of

people infected with HIV. Depression is the most important affec-

tion, the prevalence in comparison with general population arises

to 37%. Psychotic symptoms in patientswithHIV are a very frequent

entity, in some cases, these symptoms are pre-existent in others the

evolution of the infection or a medical cause related with the infec-

tion can cause its apparition. Psychosis and depression in patients

with HIV have some clinical and therapeutical considerations.

Antidepressants and antipsychotics have many pharmacological

interactions with antiretroviral therapy.

Objectives

Review the efficacy and safety of antidepressants and

antipsychotics in patients with HIV infection.

Methods

PubMed was searched for articles published between

1966 and January 1, 2015, using the search terms HIV, AIDS, depres-

sion, phycosis, antipsychotics, antidepressants, antiretrovirals. We

selected randomized placebo controlled or active comparator con-

trol trials.

Results

Twelve studies for depression treatment and 2 studies

for psychosis treatment in patients with HIV infection. Selective

serotonin reuptake inhibitors (SSRI) especially fluoxetine and tryci-

clic antidepressants are effective in treating depressive symptoms

in patients with HIV infection. Testosterone and stimulants have

been used in patients with mild depressive symptoms, however

studies with these agents had a small sample size. Haloperidol

and chlorpromazine were effective for AIDS delirium, there are not

controlled trials with other antipsychotics.

Conclusions

Psychiatrists must be concern about the clinical

particularities of patients with HIV and depression or psychotic

symptoms. The election of antidepressant or antipsychotic has to be

made very carefully because of their side effects and interactions.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.271

EW154

Living with Parkinson disease – the

central role of primary care physicians

and a multidisciplinary approach

M. Oliveira

, M. Marinho , C. Santos

Centro Hospitalar São João - EPE, Psychiatry and Mental Health

Clinic, Porto, Portugal

Corresponding author.

Introduction

Parkinson disease is a frequent neurodegenerative

disorder. Presence of psychopathology is well described in this ill-

ness, nevertheless the etiology is still unknown.

Methods and aims

The authors present a clinical case of a patient

with idiopathic Parkinson disease with depressive symptoms after

the decline of his functioning. We aim to emphasize the impor-

tance of amultidisciplinary approach and the central role of general

physicians in screening these situations.

Results

The patient is a male with 64 years old, reformed with

a personal history of hypertension. With 62 years old he started

with mild motor complaints that got worse over time, culminat-

ing after a year and half on him being almost dependant for most

of his daily activities. He also started to express feelings of sad-

ness, despair, and recurrent thoughts of death. He refused to seek

out medical help, but was convinced by his wife to consult his

general physician that observed the patient and referenced him

to Neurology and Psychiatry consultations. He also started ser-

traline 50 mg/day. He was diagnosed with Parkinson disease and

started medication with ropinirole, levodopa and carbidopa with

a good response. In Psychiatry consultation the dose of sertraline

was increased to 100mg/day with improvement, and it was pro-

vided information on the disease to the patient and family and also

supportive psychotherapy.

Conclusions

General physicians have a privileged position on

screening patients with psychopathology when other physical con-

ditions or illnesses are present. The fast and correct referencing of

these patients can improve the prognosis.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.272

EW155

Psychological mechanisms of the

formation of non-psychotic mental

disorders in patients with

hyperthyroidism

O. Pityk

1 ,

, M .

Pityk

2 , I. K

uzhda

3

1

Ivano-Frankivsk National Medical University, Department of

Psychiatry- Narcology and Medical Psychology, Ivano-Frankivsk,

Ukraine

2

Ivano-Frankivsk National Medical University, Department of

Neurology, Ivano-Frankivsk, Ukraine

3

Ivano-Frankivsk Regional Children Hospital, Department of

Ophthalmology, Ivano-Frankivsk, Ukraine

Corresponding author.