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S166

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

EW146

The prevalence of depression and its

correlates in ankylosing spondylitis:

A systematic review and meta-analysis

C. Hopkins

1 ,

, C. Moulton

2

1

Prospect Park Hospital, Berkshire Healthcare NHS Foundation Trust,

Reading, United Kingdom

2

Institute of Psychiatry Psychology & Neuroscience, King’s College

London, London, United Kingdom

Corresponding author.

Introduction

Ankylosing spondylitis (AS) is a chronic inflam-

matory disease, associated with significant pain, functional

impairment, and diminished quality of life. However, there is sig-

nificant uncertainty regarding the prevalence of depression in AS

and its associations.

Objectives

We performed a meta-analysis to examine the preva-

lence of depression in AS and its associated correlates.

Methods

The study protocol was prospectively registered with

PROSPERO (CRD42015019676). EMBASE, Medline, PsycINFO and

Web of Science were systematically searched for cross-sectional

studies with

50 adult AS patients, which reported depression

prevalence using diagnostic criteria or a validated screening tool.

Depression prevalence, tool and threshold used, age, gender, dis-

ease duration, as well as measures of disease activity, functional

impairment, pain and innate inflammation, were abstracted. Open-

Meta was used to calculate pooled prevalence estimates and to

conduct meta-regression.

Results

Eight hundred and seventy-seven texts were identified

and 17 studies satisfied inclusion criteria, totalling 3187 partici-

pants (75.2% male). Six diagnostic tools and 10 different thresholds

were reported, with depression prevalence estimates ranging from

4.9–55.5%. In studies using the depression subscale of the Hospi-

tal Anxiety and Depression Scale (HADS-D), 37.1% of participants

satisfied criteria for mild (

8) and 8.2% met criteria for moderate

depression (

11). Multivariate meta-regression demonstrated sig-

nificant positive correlations between depression and, respectively,

disease activity (

P

< 0.001) and C-reactive protein (

P

< 0.001).

Conclusions

The prevalence of depression in AS is comparable

with that of other rheumatic and degenerative diseases. Moreover,

depression demonstrates significant associations with age, inflam-

mation and disease activity, which require further investigation in

prospective studies.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.264

EW147

Medically unexplained

syndromes–Looking for common

reasons

A. Kulik

, A. Smotrycka

The John Paul II Catholic Uniwersity of Lublin, Department of

Psychotherapy and Health Psychology, Lublin, Poland

Corresponding author.

Approximately 15% of general practice doctor’s patients and 50% of

patients with chronic disease experience persistent physical symp-

toms, which do not have medical reasons. Those symptoms are

often associated with high levels of distress, limited efficiency and

consumption of health resources. Each set of symptoms has partic-

ular diagnostic features and own operational definition. However,

there is a phenomenon of combination of different syndromes.

Approximately 96% of patients have several concurrent diagnoses

of different syndromes at the same time. One of the explicative

hypotheses is the premise that there is a latent factor common for

all medically unexplained syndromes (Deary, 1999). The verifica-

tion of the assumption about latent factor was based on studies of

premenstrual syndrome (PMS) and chronic fatigue (CF). The aim of

this study is to determine the relationship between selected sets of

symptoms and their conditions in the biopsychosocial paradigm.

Hundred and fourty-nine young women (aged 18–27 years) were

examined following questionnaires: PSST, CFSQ, NEO-FFI, PTS, TPI,

KAS. The relationship between symptoms of PMS and CF is 0.517

(

P

= 0.000). The adopted model explaining variables: (1) the PMS

33.3% of the variability of results, the most important are: neuroti-

cism ( = 0.436), the strength of excitation ( = 0.229) and negative

emotions–anger ( = 0.206); 2) in CF 57.1% of the variability of

results, the most important are: neuroticism ( = 0.298) and neg-

ative emotions-anxiety ( = 0.275). The relationship between the

severity of different medically unexplained syndromes in women

ismoderate. Among biopsychosocial determinants themost impor-

tant is the severity of neuroticism and negative emotionality.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.265

EW148

Psychological factors influence the

symptoms of Gastroesophageal Reflux

Disease (GERD) and their effect on

quality of life in Korean fire fighter

S.Y. Lee

1 ,

, D.I. Jon

2

, M. Kyung-Joon

3

1

Wonkwang University and Hospital, Psychiatry, Iksan, Republic of

Korea

2

Hallym University Colloege of Medicine, psychiatry, Chuncheon,

Republic of Korea

3

Chungang University College of Medicine, psychiatry, Seoul,

Republic of Korea

Corresponding author.

Objective

The aim of the study was to investigate the psycho-

logical factors influence the symptoms of gastroesophageal reflux

disease (GERD) and their effect on quality of life in Korean Fire

Fighters.

Methods

This study examined data collected from1217 fire fight-

ers. Depression andAnxietywere identified using the Patient health

questionnaire-9(PHQ-9) and the 7-item Generalized Anxiety Dis-

order Scale. Occupational stress and Stress coping were identified

using the KOSS-26 and the Ways of Coping Checklist-Revised. Self-

esteem and quality of life were identified using the Rosenberg’s

Self-Esteem Scale and World Health Organization quality of life

scale abbreviated version (WHOQOL-BREF). The scores for anxiety,

depression and QoL of the two groups were analyzed. The correla-

tion between psychological factors and QoL was also analyzed.

Results

Current psychological variables were associated with

increased odds of concurrent GERD-related symptoms. Current

depression, anxiety and stress were associated with increased

odds of GERD-related symptoms. According to the WHOQOL-BREF,

depression, anxiety, stress, stress coping and self-esteemwere sig-

nificantly correlated with quality of life in patients with GERD.

Quality of life was obviously affected by psychological variables

in patients with GERD.

Conclusions

These results indicate that psychological symptoma-

tology, depression, anxiety, occupational stress and self-esteemare

associatedwithGERD-related symptoms. Acknowledging this com-

mon comorbidity may facilitate recognition and treatment, and

opens new questions as to the pathways and mechanisms of the

association.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.266