European Psychiatry - Volume 33 - March 2016

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S730 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805
EV1192
Preventable schizophrenia
C.F. Silvia ∗, A. Gómez Peinado , P. Cano Ruiz
HNSPS, Psiquiatria, Albacete, Spain
∗ Corresponding author.
Introduction Schizophrenia is a psychiatric disorder with mul-
tiple causes, including genetic, immune, environmental causes of
various kinds, which all increase the vulnerability and predispo-
sition to the disorder. Among them stand out prenatal infections,
thus being a preventable risk potential factor in our daily clinical
practice.
Objectives To analyze the relation between prenatal infections
and schizophrenia.
Methods Review of the subject and recent articles on schizophre-
nia in psychiatric guides and magazines.
Results After analyzing several studies, it have shown that prena-
tal infections, where the nervous system is not yet fully developed,
may be a risk factor for the development of schizophrenia in adults,
in relationwith genetically predisposed individuals. Infections such
as influenza, especially during the first quarter of gestation; rubella,
toxoplasma and herpes simplex virus-type 2 are related to poten-
tially increase risk of suffer schizophrenia.
Conclusions Prenatal infections, especially in the first quarter and
the periconceptional period, constitute a risk factor in individuals
with vulnerability to develop schizophrenia. Awareness and pre-
vention is important in the pregnant population of the influence of
these infections on the possible origin of psychotic episodes.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
Further readings
Babulas V, Factor-Litvak P, Goetz R, et al. Prenatal exposure to
maternal genital and reproductive infections and adult schizophre-
nia. Am J Psychiatry 2006;163(5):927–9.
Brown AS, Susser ES. In utero infection and adult schizophrenia.
Ment Retard Dev Disabil Res Rev 2002;8(1):51–7.
EV1193
Medication adherence in
schizophrenia
F. Fatma , I. Baati , S. Omri , R. Sallemi ∗, J. Masmoudi
Hédi Chaker University Hospital, Psychiatry A, Sfax, Tunisia
∗ Corresponding author.
Introduction Compliance is a major issue in the treatment of
schizophrenia. Many studies have attempted to identify factors that
influence it.
Objective To assess treatment adherence in patients with
schizophrenia. To identify factors correlated with poor adherence.
Methods It was a cross-sectional, descriptive and analyti-
cal study, involving 37 outpatients with DSM-IV diagnosis of
schizophrenia, followed in the psychiatry department at the Hédi
Chaker University Hospital of Sfax (Tunisia). The questionnaire
included socio-demographic, clinical and therapeutic data. We also
used the Medication Adherence Rating Scale “MARS”, the Insight
Scale “IS” and the Stigma Scale (9 items).
Results The average age was 36.4 years. The majority of patients
was male (68.8%), did not exceed the level of secondary education
(89.2%) and had a low socioeconomic level (84.4%).
Paranoid schizophrenia was the most frequent type of schizophre-
nia (54.1%). Atypical antipsychotic were prescribed in 40.5% of
cases.
Patients were non-adherent to treatment in 56.8% of cases. The fac-
tors correlated with poor adherence were: psychoactive substance
use (P = 0.036), sexual dysfunction (P = 0.036), complexity of treat-
ment ( P = 0.036), poor insight according to the subscale “awareness
of the need for treatment” of the IS (P = 0.047) and high score on the
subscale “discrimination” of the Stigma Scale (P = 0.008).
Conclusion Tunisian schizophrenic patients have a poor adher-
ence to treatment. Acting on risk factors (such as substance
use, sexual side effects, poor insight and discrimination percep-
tion) would improve patient compliance and management of
schizophrenia.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1194
Rehospitalization rate of first episode
and chronic schizophrenia patients
one year after discharge
R. Softic∗, E. Becirovic , M. Mirkovic Hajdukov
University Clinical Center Tuzla, Psychiatry Clinic, Tuzla, Bosnia and
Herzegovina
∗ Corresponding author.
Introduction Relapse rate among patientswith schizophrenia can
determinate outcome of illness. Up to 40% of patients with first psy-
chosis responds well to treatment. Despite this fact relapse rate is
still high, in particular if treatment is discontinuated. Frequent use
of first generation antipsychotics (FGA) in underdeveloped coun-
tries can be one of possible reasons for treatment discontinuation
and consequent relapse.
Aims To analyse rehospitalisation rate in patients with first and
multiple episodes of schizophrenia, and compare it with medica-
tion choice.
Methods Retrospective analysis of medical records of patients
with schizophrenia hospitalised in Psychiatry Clinic of University
Clinical Center Tuzla in period from year 2011 to 2013.
Results During the two-year period, 37 patientswith first episode
of schizophrenia were hospitalised. Second generation antipsy-
chotics (SGA) were used in 40.5%, and first generation in 13.5%, long
acting injectibles - first generation (LAI)were used in8.1%, and com-
bination of FGA’s and SGA’s in 5.4% of cases. In the same period, 121
patientswithmultiple episodes of schizophreniawere hospitalised.
SGAwere used in 21.4%, FGA in 33%, LAI’s in 47.1%, and combination
FGA’s and SGA’s in 35.5% of cases. Relapse rate in the first year after
discharge was 16.2% in group with first psychotic episode, and 33%
in the group with multiple episodes of schizophrenia.
Conclusion High relapse rate in group withmultiple episodes can
be explained with nonadherence regarding the side effects of too
frequent use of FGA’s.
Keywords Schizophrenia; Relapse rate; Adherence;
Antipsychotics
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1195
Substance abuse in first episode
psychosis: Baseline characteristics and
clinical outcome
A. Toll ∗ ané , D. Bergé , V. Pérez-Solà
Hospital del Mar, Institut de Neuropsiquiatria i Addiccions (INAD),
Barcelona, Spain
∗ Corresponding author.
Introduction There are high rates of substance use disorders
(SUD) amongst first episode psychosis (FEP). SUD have been linked
to better premorbid adjustment, more severe positive and negative
symptoms at presentation and poorer symptomatic and functional
outcome [1]. Moreover, shorter duration of untreated psychosis