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S728

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

EV1186

A pilot early psychosis intervention

programme in Bolivia

G. Rivera Arroyo

Hospital Universitario Japonés, Mental Health, Santa Cruz, Bolivia

The problem

Less than half of the more than 250 adolescents and

young adults who are estimated to experience a first episode of

psychosis in the city of Santa Cruz each year are ever diagnosed

and receive treatment.

Of those patients who are eventually diagnosed, the average dura-

tion of their symptoms of psychosis prior to receiving treatment is

estimated to be over 2 years.

The opportunity

Multiple psychosocial variables, such as the

reaction of patients and their families to symptoms of psychosis,

which play a vital role in determining long-termoutcomes, demon-

strate their highest degree of flexibility during the period of early

psychosis. Psychological, social and evidence-based pharmacolog-

ical interventions undertaken during this time frame can have a

profound impact on the life-course of an individual with psychosis.

Our solution

We propose to establish a pilot early psychosis inter-

vention program that will provide age appropriate biopsychosocial

treatment and support for 15–25 years old with first episode psy-

chosis and their families in Santa Cruz. This will improve short

and long-term outcomes for those with psychosis, increase speed

of recovery, decrease the need for hospitalization, reduce family

disruption and decrease rates of relapse.

By utilizing a mobile, multidisciplinary treatment team that

emphasizes the roles of trained casemanagers focused onproviding

intensive individual and family support in the home, this program

will provide culturally appropriate care that will leverage contribu-

tions from a limited supply of psychiatrists and shift dependence

away from a fragmented medical system.

Disclosure of interest

The author has not supplied his declaration

of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.2171

EV1187

Impact of vulnerability to stress in the

development and course of first

psychotic episode

L. Rossini Gajsak

1 ,

, M. Celic Ruzic

1

, M. Rojnic Kuzman

2

1

Neuropsychiatric Hospital Dr. Ivan Barbot, Department of Biological

Psychiatry, Popovaca, Croatia

2

University Hospital Centre Zagreb, Department of Psychiatry,

Zagreb, Croatia

Corresponding author.

Introduction

The stress diathesis hypothesis is one of the lead-

ing models of etiology of psychotic disorders. Cortisol is one of

the most researched stress hormone; yet its role in first psychotic

episode is currently subject of many researches. Psychotic disorder

occurs when “enough” stress attacks vulnerable personality. Stress

response activatesHPAaxis that results in cascade effects on several

body systems (immune, neuroendocrine and inflammatory). Dys-

regulation of the HPA axis and increased cortisol levels have been

implicated in psychotic as well as in other psychiatric disorders.

Objective

To follow treatment response through changes in clin-

ical status and stress biomarkers evaluation in longitudinal 18

months research in drug naive FEP.

Aim

To assess endocrine and autonomic responses to acute psy-

chosocial stress, their associations with onset of the first psychotic

episode and their subsequent remission.

Methods

We studied 17 subjects with FEP and age and gender

matched controls who were exposed to the Trier Social Stress Test.

Other materials have explored clinical status through standard-

ized clinical psychiatric interview and validated psychiatry scales

as well as measured laboratory biomarkers (cortisol, prolactin,

insulin).

Results

Our preliminary findings on a sample of 40 participants

indicate a differences between patients and controls in terms of

response to stress measured by TSST.

Conclusion

In our continued longitudinal research, we plan to

further explore the role of hypothalamic-pituitary-adrenal activ-

ity in onset and course of psychotic disorder and its relation with

other biomarkers.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.2172

EV1188

A case of rare allele T 126, 30,32 base

pairs in a schizophrenic patient: A

study case

A.I. Sabau

1 ,

, P. Cristina

2

, B. Valerica

2

, P. Delia Marina

3

1

Vasile Goldi, Western University of Arad, Arad, Romania

2

Vasile Goldi, Western University of Arad, the Institute of Life

Science, Arad, Romania

3

Vasile Goldi, Western University of Arad, Psychiatry Department,

Emergency County clinical Hospital of Arad, Arad, Romania

Corresponding author.

Introduction

Schizophrenia is a severe and complex disease clin-

ically characterized by disturbed thought processes, delusions,

hallucinations and reduced social skills. Gene coding for neregulin

1 (NRG 1) located in 8 p21chromosomeand single nucleotide poly-

morphism (SNPs) have been identified strongly supporting

NRG1

gene as a susceptibility gene for schizophrenia.

Objective

The present preliminary study, determines the rela-

tionship between polymorphism nucleotide sites (SNPs2) of

NRG1

gene and schizophrenia.

Aims

Identifying rare allele T of neregulin 1 genein schizophrenic

patients.

Method

We analyzed the polymorphism (SNPs2) of

NRG1

gene

in 20 patients recruited from Psychiatry Department of Emergency

Clinical Hospital of Arad diagnosed with schizophrenia according

to DSM-5-TM and ICD-10 criteria and 10 healthy controls. From all

subjects, we obtained 2mL of peripheral blood samples. Genomic

DNA was extracted using the phenol-chloroform method. Geno-

typing was performed byPCR-based RFLP analysis for all subjects.

The obtained PCR product mixture was completely digested with

restriction enzyme, separated on SNP1 and SNP2 agarose gel. We

present the case of a 31 years old, male, schizophrenic patient with

the SNPs2 polymorphism and rare allele T 126.

Results

In both groups, common allele G 127 and 60 base pairs

was identified but only 2 schizophrenic patients presented rare

allele T 126 and 30,32 base pairs.

Conclusions

The polymorphism SNPs2 of

NRG1

gene with rare

allele T 126 and 30,32 base pairs, may play a role in predisposing

an individual to schizophrenia. Further and extended replicating

studies with multiple sequencing of

NRG1

gene are necessary.

Keywords

Schizophrenia;

Neregulin 1

(

NRG1

) gene; Allele T 126

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.2173

EV1189

Role of specialized hospital units in

integrative treatment of first and early

course psychosis – 10-year experience

of Zagreb first psychosis unit

A. Savic

, D. Ostojic , A. Silic , A. Bacekovic , V. Jukic

University Psychiatric Hospital Vrapce, Department of Diagnostics

and Intensive Care, First Psychosis Unit, Zagreb, Croatia

Corresponding author.