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S726

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

4

Campo del Vescovo Union, Therapeutic Psychiatric Community, La

Spezia, Italy

Corresponding author.

Introduction

Limited research has been devoted to the subjective

impact of switching antipsychotic maintenance treatment (AMT)

from oral to LAI formulation in schizophrenia.

Objective

To compare LAI AMT with oral AMT in terms of sub-

jective experience of treatment, taking into account the effects on

psychopathology.

Methods

Twenty outpatients (7 males, mean age 40.55

±

11.00

years) with remitted schizophrenia treated with either olanza-

pine or paliperidone and switching from oral to LAI AMT were

recruited before the switch (LAI-AMT group). A group of 20 remit-

ted schizophrenic subjects with oral AMT andmatched for themain

socio-demographic, clinical and treatment variables made up the

controls (oral-AMT group). All participants were assessed bymeans

of the PANSS and of the SWN-K at baseline (T0) and after 6 months

(T1).

Results

Between T0 and T1, general psychopathology of the

PANSS and all but one of the SWN-K dimensions (except for “social

integration”), showed significantly higher percent improvements

in the LAI-AMT group compared to the oral-AMT group. After 6

months (T1), the LAI-AMT group showed significantly lower PANSS

total and general psychopathology scores, as well as higher mean

score of perceived “mental functioning” compared to the oral-

AMT group. Item analysis of the general PANSS at T1 showed

significant differences between the two groups in anxiety, ten-

sion, depression, guilt feelings, poor attention, and active social

avoidance.

Conclusions

Our data on switching fromoral to LAI AMT in remit-

ted schizophrenia suggest a better efficacy of the latter in terms of

improvement of general psychopathology and subjective experi-

ence of treatment.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.2165

EV1181

LAI versus oral antipsychotic

treatment of schizophrenia: A

12-month prospective study on

patient’s attitude towards treatment

and quality of life

F. Pietrini

, A. Ballerini , I. Burian , B. Campone , F. Chiarello ,

E. Ciampi , E. Corsi , N. Ferruccio , M. Moneglia , L. Poli ,

A. Santangelo , S. Spitoni , V. Ricca

University of Florence, Department of Neuroscience, Psychology, Drug

Research and Child Health, section of Neuroscience, Florence, Italy

Corresponding author.

Introduction

It is still a matter of debate whether LAI antipsy-

chotics are able to significantly improve patient’s attitude towards

treatment.

Objective

The aim of this 12-month observational study was to

investigate the impact of switching antipsychotic treatment from

oral to LAI formulation on patient’s attitude towards treatment and

quality of life.

Methods

A total of 41 schizophrenic patients (25 males, mean

age 42.10

±

11.88 years) were recruited. Patients were expected

not to need significant changes in concomitant treatments. All

patients were under a stabilized therapy with a single oral antipsy-

chotic (either olanzapine or paliperidone) and were switched to

the equivalent maintenance regimenwith the long-acting formula-

tion of the same antipsychotic (olanzapine pamoate or paliperidone

palmitate). Patients were assessed before the switch (T0), and after

6 (T1) and 12 months (T2) of LAI antipsychotic treatment by means

of the YMRS, MADRS, PANSS, DAI-10 and SF-36.

Results

Our data evidenced an overall significant improvement

of psychopathology, adherence and quality of life over the 12-

month period (T0 vs. T2). In particular, while all of the measures

significantly improved in the first semester (T0 vs. T1), only YMRS,

positive PANSS and DAI-10 improved both in the first and in the

second semester (T1 vs. T2), indicating an additional advantage of

a prolonged LAI treatment on these clinical dimensions.

Conclusions

The switch from oral to long-acting antipsychotic

treatment may provide considerable advantages in improving

patient’s attitude towards (and therefore adherence to) treatment.

Part of this improvement could be related with a better efficacy on

psychopathology and quality of life.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.2166

EV1182

Depot medication and compulsory

treatment

A. Poc¸ as

1 ,

, S. Azenha

2

1

Centro Hospital de Leiria, Servic¸ o de Psiquiatria, Braga, Portugal

2

Hospital de Braga, Servic¸ o de Psiquiatria, Braga, Portugal

Corresponding author.

Introduction

It is estimated that 90% of patients with schizophre-

nia only adhere partially to the treatment. The use of depot

medication is an option for patients with schizophrenia rather

using it in voluntary or compulsory treatment.

Objectives and aims

We tried to check on differences in the

outpatient treatment of schizophrenia among patients receiving

compulsory (involuntary outpatient commitment [IOC]) and vol-

untary treatment and analyzed the outcomes in patients in IOC

taking oral versus depot antipsychotics.

Method

We assessed and compared socio-demographic and clin-

ical features, therapeutics likelihood ofmedication adherence (with

Medication adherence rating scale [MARS]), personal and social

performance (PSP) scale and predominant kind of symptoms (with

Positive and Negative Syndrome Scale [PANSS]).

Results and conclusion

All patients were taking antipsychotics,

and 63% of compulsive and 33% of volunteers were taking oral

and injectable antipsychotics simultaneously. We observed that

21% of compulsive and 30% of the volunteers were simultaneously

doing typical and atypical antipsychotics. Depot medication was

being taken by 84% of patients in IOC and in just 54% of volunteers.

We do not find statistically significant differences in outcomes of

patients in IOC with injectable medication (

n

= 16) compared to

those who were only with oral medication (

n

= 3), in terms of prob-

ability of adherence to medication, functionality or predominant

symptomatic type. Compulsive patients had higher use of typical

antipsychotics, perhaps in order to have a more sedative effect

in patients with more severe disease. The prevalence of atypical

antipsychotics in volunteers focuses on the need of a better cogni-

tive performance and functionality.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.2167

EV1183

Catatonic schizophrenia vs anti-NMDA

receptor encephalitis – A video case

report

A. Ponte

1 ,

, J. Gama Marques

1

, L. Carvalhão Gil

1

, C. Nobrega

2

,

S. Pinheiro

3

, A. Brito

3

1

Centro Hospitalar Psiquiátrico de Lisboa, Psychiatry, Lisbon,

Portugal

2

Centro Hospitalar Psiquiátrico de Lisboa, Neurology, Lisbon,

Portugal