European Psychiatry - Volume 33 - March 2016

729 / 812

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805 S725
4 Centro de Rehabilitación Psicosocial y Laboral, Psicology, Talavera
de la Reina, Spain
∗ Corresponding author.
Introduction Sexual disinhibition is uncommon in patients with
schizophrenia and are included within the behavioral disorders
along with others such as agitation, aggression, sleep disorders
and circadian rhythm, due to multiple reasons: isolation, rejection,
difficulty in personal relationships.
Objectives We report the case of a male patient aged 58 with
multiple previous admissions for behavioral alteration symptoms,
including exhibitionism. He is referred as irritable, uninhibited and
sleeping disorders. There is a risk of flight as he is difficult to be held
so it is feared that he can be run over by a car. He shows a marked
self-referentiality.
Methodology The patient is admitted. He properly gets used to
the rules of the Ward. Pharmacological adjustment is performed.
During his admittance he shows no behavior disorders neither
episodes of self or hetero aggression and poor impulse. He properly
makes comments of what happened during his stay. He responds
well to treatment prescribed. Sleep pattern is restored.
Results Schizophrenia (undifferentiated) 295.90 (F.20.3); intel-
lectual disability mild 317 (F70); neurocognitive disorder (possi-
ble).
Conclusions This is unusual case because it is normal that the
sexual function of such patients is adversely affected, not find-
ing numerous cases of disinhibition in our medical consultation.
This is due to the different aspects that are affected, biological
(drugs), psychological and social levels. We have different ther-
apeutic alternatives to address this problem. However, they may
hinder sociability and patient rehabilitation.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1178
Implications of immunity and
inflammation in schizophrenia and
related psychotic disorders
J. Perestrelo∗, D. Mota , A. Coutinho , M. Santos , G. Lapa
Centro Hospitalar de Vila Nova de Gaia/Espinho, Psychiatry, Porto,
Portugal
∗ Corresponding author.
Introduction Intricate interactions between the immune system
and the brain might have important etiological and therapeu-
tic implications for neuropsychiatric brain disorders. A probable
association between schizophrenia and the immune system was
postulated over a century ago, and is supported by epidemiological
and genetic studies pointing to links with infection and inflamma-
tion.
Objective Todescribe some important areas of research regarding
immune response in schizophrenia and related psychotic disorders
and discuss potential mechanisms and therapeutic implications of
these findings.
Aims Associations between immune response, inflammation and
schizophrenia and related psychotic disorders are reviewed.
Methods A literature review of the theme is surveyed. Several
articles were search on MEDLINE with the keywords: schizophre-
nia, psychosis, inflammation, immunity, infection.
Results Schizophrenia is a multifactorial disease. It is associated
with multiple genetic loci that confer risk, in addition to develop-
mental and postnatal risk factors. Antipsychotic-naive first-episode
psychosis and acute psychotic relapse seems to be associated with
increased serum concentrations of interleukin 6 and other proin-
flammatory cytokines, which are normalized after remission of
symptoms with antipsychotic treatment.
Conclusions Inflammation and immune dysfunction might
contribute to cognitive, negative, and positive symptoms in
schizophrenia. Identification of specific inflammatory pathways for
neuropsychiatric symptoms would provide novel targets for ther-
apeutic intervention.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1179
Psychosocial interventions for
schizophrenia
A. Pestana Santos ∗ mílcar Teixeira
Centro Hospitalar e Universitário de Coimbra, Psychiatry, Coimbra,
Portugal
∗ Corresponding author.
Introduction Schizophrenia is a stress-related neurobiological
disorder characterized by disturbances in the form and content
of an individual’s thought and perceptual processes. People with
schizophrenia are facedwith social impairment, which affects their
global functioning.
Aims The authors aim to clarify the role of psychosocial interven-
tions for the treatment and recovery of people with schizophrenia.
Methods The authors conducted a literature search in MED-
LINE, PsycINFO, and Cochrane Library using the following words
“psychosocial practices”, “illness management and recovery”,
“rehabilitation” and “schizophrenia”.
Results In schizophrenia as in other psychiatric diseases, a
multimodal approach will increase the success of the interven-
tion. On psychosocial point of view, the interventions take into
consideration three factors: the characteristics of the individu-
als, the community requirements and the supportiveness of the
environment. According to literature psychosocial treatments for
schizophrenia is based on the recovery model of mental health and
the expanded stress-vulnerability model. Psychosocial evidence-
based practices include social skills training which help individuals
to practice and acquire behavioral skills in social interactions;
cognitive behavior therapy targets maladaptive thoughts and
behaviors; cognitive remediation approaches impairment in infor-
mation processing skills to indirectly improve social functioning.
Other psychosocial practices are family psychoeducation, sup-
ported employment and assertive community treatment. Although
the later improves daily living skills, it has little impact on psy-
chosocial functioning.
Conclusions Psychosocial interventions are important for treat-
ment and recovery of people with schizophrenia. Depending on
the used practices, it reduces the number of relapses as well as it
improves social functioning of people with schizophrenia.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1180
LAI versus oral antipsychotic
maintenance treatment of
schizophrenia: A case-control study
on subjective experience of treatment
F. Pietrini ∗ Spadafora atini . Talamba
E. Burchi alderani emignani allardo
C. Andrisano Boncompagni Manetti allerini
V. Ricca
1 University of Florence, Department of Neuroscience, Psychology,
Drug Research and Child Health, section of Neuroscience, Florence,
Italy
2 University of Bologna, Department of Biomedical and Neuromotor
Sciences, Bologna, Italy
3 Local Health Trust of Bologna, Department of Mental Health and
Substance Abuse, Bologna, Italy