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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

S725

4

Centro de Rehabilitación Psicosocial y Laboral, Psicology, Talavera

de la Reina, Spain

Corresponding author.

Introduction

Sexual disinhibition is uncommon in patients with

schizophrenia and are included within the behavioral disorders

along with others such as agitation, aggression, sleep disorders

and circadian rhythm, due to multiple reasons: isolation, rejection,

difficulty in personal relationships.

Objectives

We report the case of a male patient aged 58 with

multiple previous admissions for behavioral alteration symptoms,

including exhibitionism. He is referred as irritable, uninhibited and

sleeping disorders. There is a risk of flight as he is difficult to be held

so it is feared that he can be run over by a car. He shows a marked

self-referentiality.

Methodology

The patient is admitted. He properly gets used to

the rules of the Ward. Pharmacological adjustment is performed.

During his admittance he shows no behavior disorders neither

episodes of self or hetero aggression and poor impulse. He properly

makes comments of what happened during his stay. He responds

well to treatment prescribed. Sleep pattern is restored.

Results

Schizophrenia (undifferentiated) 295.90 (F.20.3); intel-

lectual disability mild 317 (F70); neurocognitive disorder (possi-

ble).

Conclusions

This is unusual case because it is normal that the

sexual function of such patients is adversely affected, not find-

ing numerous cases of disinhibition in our medical consultation.

This is due to the different aspects that are affected, biological

(drugs), psychological and social levels. We have different ther-

apeutic alternatives to address this problem. However, they may

hinder sociability and patient rehabilitation.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.2162

EV1178

Implications of immunity and

inflammation in schizophrenia and

related psychotic disorders

J. Perestrelo

, D. Mota , A. Coutinho , M. Santos , G. Lapa

Centro Hospitalar de Vila Nova de Gaia/Espinho, Psychiatry, Porto,

Portugal

Corresponding author.

Introduction

Intricate interactions between the immune system

and the brain might have important etiological and therapeu-

tic implications for neuropsychiatric brain disorders. A probable

association between schizophrenia and the immune system was

postulated over a century ago, and is supported by epidemiological

and genetic studies pointing to links with infection and inflamma-

tion.

Objective

Todescribe some important areas of research regarding

immune response in schizophrenia and related psychotic disorders

and discuss potential mechanisms and therapeutic implications of

these findings.

Aims

Associations between immune response, inflammation and

schizophrenia and related psychotic disorders are reviewed.

Methods

A literature review of the theme is surveyed. Several

articles were search on MEDLINE with the keywords: schizophre-

nia, psychosis, inflammation, immunity, infection.

Results

Schizophrenia is a multifactorial disease. It is associated

with multiple genetic loci that confer risk, in addition to develop-

mental and postnatal risk factors. Antipsychotic-naive first-episode

psychosis and acute psychotic relapse seems to be associated with

increased serum concentrations of interleukin 6 and other proin-

flammatory cytokines, which are normalized after remission of

symptoms with antipsychotic treatment.

Conclusions

Inflammation and immune dysfunction might

contribute to cognitive, negative, and positive symptoms in

schizophrenia. Identification of specific inflammatory pathways for

neuropsychiatric symptoms would provide novel targets for ther-

apeutic intervention.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.2163

EV1179

Psychosocial interventions for

schizophrenia

A. Pestana Santos

, J. A

mílcar Teixeira

Centro Hospitalar e Universitário de Coimbra, Psychiatry, Coimbra,

Portugal

Corresponding author.

Introduction

Schizophrenia is a stress-related neurobiological

disorder characterized by disturbances in the form and content

of an individual’s thought and perceptual processes. People with

schizophrenia are facedwith social impairment, which affects their

global functioning.

Aims

The authors aim to clarify the role of psychosocial interven-

tions for the treatment and recovery of people with schizophrenia.

Methods

The authors conducted a literature search in MED-

LINE, PsycINFO, and Cochrane Library using the following words

“psychosocial practices”, “illness management and recovery”,

“rehabilitation” and “schizophrenia”.

Results

In schizophrenia as in other psychiatric diseases, a

multimodal approach will increase the success of the interven-

tion. On psychosocial point of view, the interventions take into

consideration three factors: the characteristics of the individu-

als, the community requirements and the supportiveness of the

environment. According to literature psychosocial treatments for

schizophrenia is based on the recovery model of mental health and

the expanded stress-vulnerability model. Psychosocial evidence-

based practices include social skills training which help individuals

to practice and acquire behavioral skills in social interactions;

cognitive behavior therapy targets maladaptive thoughts and

behaviors; cognitive remediation approaches impairment in infor-

mation processing skills to indirectly improve social functioning.

Other psychosocial practices are family psychoeducation, sup-

ported employment and assertive community treatment. Although

the later improves daily living skills, it has little impact on psy-

chosocial functioning.

Conclusions

Psychosocial interventions are important for treat-

ment and recovery of people with schizophrenia. Depending on

the used practices, it reduces the number of relapses as well as it

improves social functioning of people with schizophrenia.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.2164

EV1180

LAI versus oral antipsychotic

maintenance treatment of

schizophrenia: A case-control study

on subjective experience of treatment

F. Pietrini

1 ,

, M .

Spadafora

1 , L. T

atini

1 , G.A

. Talamba

1 ,

E. Burchi

1 , E. C

alderani

1 , S. G

emignani

1 , L. M

allardo

1 ,

C. Andrisano

2 , G.

Boncompagni

3 , M.

Manetti

4 , A. B

allerini

1 ,

V. Ricca

1

1

University of Florence, Department of Neuroscience, Psychology,

Drug Research and Child Health, section of Neuroscience, Florence,

Italy

2

University of Bologna, Department of Biomedical and Neuromotor

Sciences, Bologna, Italy

3

Local Health Trust of Bologna, Department of Mental Health and

Substance Abuse, Bologna, Italy