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S720

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

course of this disease. This process emphasizes all the cognitive

as both individual capacities as motor through an approach to

vocational, residential, recreational, social and educational support,

tailored to the unique demands of the patient, in every situation and

custom mode.

For this, working through concepts such as social cognition and

insight, interdisciplinary way, so to SET goals and accomplish them

with a specific planning.

Schizophrenia is a chronic disease that occurs in 1 to 2% of theworld

population, and causes social marginalization and stigmatization

in patients who have it. Be treated, then, since the integration of

multidimensional therapeutic resources.

In this paper, descriptively explains the techniques and activities

developed individually for each professional and interdisciplinary

area of building situational and individual patient diagnosis, poten-

tial and limitations as well as the specific treatment that may lead

to improved cognitive and motor skills of the patient, and from it

an improvement in their social inclusion and quality of life.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.2146

EV1162

Effect of switching to long-acting

injectable (LAI) aripiprazole on

long-lasting antipsychotic-induced

hyperprolactinemia: A report of two

cases

M. Juncal Ruiz

, B. Fernández-Abascal Puente ,

R. Landera Rodríguez

Hospital Universitario Marqués de Valdecilla, Psychiatry, Santander,

Spain

Corresponding author.

Introduction

Antipsychotic-induced

hyperprolactinemia

(> 29 ng/ml in women) is associated with relevant side-effects.

Aim

We describe the case of two women aged 50 and 54 years,

respectively, diagnosed with schizophrenia who were receiving

outpatient treatment with paliperidone depot 100mg/month and

risperidone depot 50mg/2weeks, respectively and complained of

oligoamenorrhoea and amenorrhoea for at least 6months.

Methods

Routine blood tests showed hyperprolactinemia of

203.5 ng/ml and 306.2 ng/ml, respectively. The patients were eval-

uated by the Endocrinology unit and an MRI was performed

discarding the presence of any primary brain condition. Both

patients were switched to LAI aripiprazole due to its partial ago-

nism of D2-brain receptors. At the time of switching both patients

were stable in terms of psychopathology.

Results

Changes in prolactin levels 3months after switching are

shown in the

Fig. 1 .

Two months after switching, both patients

regained cyclic menstrual function. After 6months, they still

showed psycopathological stability.

Conclusions

Several studies have described an improvement of

drug-induced hyperprolactinemia after switching to or adding oral

aripiprazole. In these two cases, the normalization of prolactin

levels and the resolution of oligoamenorrhoea/amenorrhoea were

observed as soon as 2–3months after switching to LAI aripiprazole.

These findings suggest that switching to LAI aripiprazole may be

an effective alternative for managing antipsychotic-induced hyper-

prolactinemia.

Fig. 1

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.2147

EV1163

Capgras-delusion in a female patient

with schizophrenia: A case report and

study of the literature

P. Kolarov

1 ,

, P. Chumpalova

1

, G. Georgiev

1

, A. Todorov

2

,

M. Stoimenova

1

1

Medical University, Pleven, Bulgaria, Department of Psychiatry and

Medical Psychology, Pleven, Bulgaria

2

University Hospital, Pleven, Bulgaria, Psychiatry Clinic, Pleven,

Bulgaria

Corresponding author.

Background

The Capgras syndrome is a rarely observed condition

in patients with different psychiatric diseases, which is character-

ized with delusional misidentification of people, places, objects,

etc.

Objective

In this case report we aim to describe the clinical char-

acteristics and manifestation of Capgras syndrome in a female

patient with schizophrenia, performa literature search on the topic

and compare our report to literature findings.

Results and discussion

A 50-year-old female patient was verbally

and physically aggressive to her family members upon admis-

sion to our center. The onset of disease was marked 2 years ago

when she first started feeling deserted and isolated and had a pre-

scribed therapy for her condition which she did not follow. During

the current admission a psychiatric assessment was performed.

Delusional misidentification of her family members was observed

and consequent food and sleep self-deprivation due to psychosis

was noted. The patient denied being suicidal but was intense and

psychotic, and reported different objects to have started disap-

pearing mysteriously from her home. The patient was diagnosed

with schizophrenia and was treated with haloperidol, olanzapine,

chlorpromazine, and biperiden. The patient was discharged in an

improved condition, without episodes of obsessive delusions and

improved communication with her relatives.

Conclusion

Although according to the literature organic substrate

may be found in some patients with Capgras syndrome, in the case

presented here it is the dominant psychotic theme, which deter-

mined the content of the disease.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.2148