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S718

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

been included in a delirium of persecution in 13 patients, delirium

of bewitchment (7 patients), mystical religious (

n

= 4) and finally

in apart of delusions of greatness (

n

= 6) so as to follow a single

assignment: to fight terrorism.

Conclusion

Delusions focused on the topic of DAECH were

observed frequently among young patients and formed an integral

part of especially persecution delirium, reflecting the collective fear

of this phenomenon.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.2139

EV1155

Analysis of the duration of untreated

illness (DUI) in the first episode

psychosis Program (FEP) in AGS South

Granada

B. Girela Serrano

, M. Guerrero Jiménez ,

C.M. Carrillo de Albornoz Calahorro , J.A. Rodrigo Manzano ,

O.B. Martínez García

Hospital Santa Ana Motril, Psiquiatría, Motril, Granada, Spain

Corresponding author.

Introduction

Duration of untreated illness (DUI) has been consid-

ered as a relevant variable used tomeasure the degree of disabilities

that are associated with psychotic disorders. In this paper we

describe a cluster of patientswith a DUI superior to 1 year according

to their symptoms and sociofamiliar functioning.

Methods

We compare a groupwith a DUI superior to 1 year (

n

= 7)

against a group with a DUI inferior to 1 year (

n

= 17).

Results

The group with a DUI superior to 1 year showed an

average age of 4 years younger (21) as the duration of untreated

psychosis (DUP) of 1 to 3months in the 80% of cases and higher

percentage of unemployed or without occupation. The 60% were

derived fromprimary care, compared to the 17% of the other group.

Although the consumption of toxic substances was similar in both

groups, no toxic psychosis were found in comparison with the 35%

present in the group with a DUI inferior to 1 year. PANSS’ profile

scored more positive and less negative symptoms. Both have sim-

ilar general psychopathology. There were group differences in the

Social Functioning Scale (SFS) with lower scores in the superior

to 1 year DUI, in the following scales: Prosocial, Autonomy, Execu-

tion and Employment. The Global Assessment of Functioning (GAF)

gives an average of almost 8 points higher.

Discussion

While the SFS shows significant differences in several

areas of social functioning, both PANSS ´profile and the family ques-

tionnaire do not support greater deterioration, as evidenced in the

GAF’s average score.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.2140

EV1156

Meta-analysis of the effectiveness of

the drug in the treatment of

schizophrenia

A. Golmohammadi Hafshejani

1 ,

, H .

Arizi

2 , A.

Abedi

2 ,

M. Shafiei Amiri

3

1

University of Isfahan, Clinical Psychology, Isfahafan, Iran

2

University Faculty of Humanities, University of Esfahan, Clinical

Psychology, Esfahan, Iran

3

Young Researchers Club, Azad University Roudehen, Clinical

Psychology, Rodehen, Iran

Corresponding author.

Introduction

In recent years, scientists have been looking for the

effects of the drug in the treatment of schizophrenia. In this meta-

analysis by integrating the results of various studies, shall specify

the size of treatment effect.

Aim

The study is based on research using meta-analysis model,

the impact of drugs on the treatment of schizophrenia.

Methods

For this purpose, nine of whichwere acceptable in terms

of methodology, and meta-analysis was performed on them.

Research tools

Meta-analysis checklist was included.

Research findings

The rate of drug treatment interventions on the

treatment of schizophrenia 2.41 respectively.

Conclusion

The study showed the effect of treatments on the

interpretation of Cohen in the treatment of schizophrenia high.

Keywords

Meta-analysis; Disorder; Schizophrenia; Drug

treatment

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.2141

EV1157

Psychosis-related polydipsia and

chronic hyponatremia – A case report

F. Gonc¸ alves Godinho

, A.L. Melo , S. Marques , D. Barrocas

Hospital Espírito Santo de Évora, Psychiatry and mental health,

Évora, Portugal

Corresponding author.

Introduction

Psychogenic polydipsia has an estimated preva-

lence of 6–20% in psychiatric population. Although first described

in the 1930s, there are few studies addressing this problem and

its management. The high water intake can lead to severe hypona-

tremia with a mortality rate high enough to merit clinical concern.

Aims

Report a case of a schizophrenic patient with psychogenic

polydipsia and hyponatremia.

Methods

Retrospective review of the clinical file and literature

research on this topic.

Results

A 41-year-old man with a long-term schizophrenia pre-

sented to the emergency room (ER) with exacerbation of psychotic

symptoms. In the prior 24months, he had stopped medication and

began excessive water intake (5 to 10 L/day). He presented with

auditory hallucinations, passivity phenomena and persecutory and

other delusional thoughts that justified this behavior – “The water

will end; I have to stock it, like camels do”. Presently he had

an asymptomatic hyponatremia (128mg/dL), but 6months before

he had been admitted in the ER with vomiting, altered state of

consciousness and convulsions secondary to severe hyponatremia

(108mg/dL). During the present hospitalization, organic causes of

hyponatremia were excluded and he was started on behavioral

measures and antipsychotics. The psychotic symptoms improved

and there was no need for water restriction after the first week,

with restored natremia values on discharge.

Conclusions

With this case report we intended to raise aware-

ness on this potentially fatal condition that despite its prevalence

has no defined diagnostic criteria, nor established controlled trials

concerning the effectiveness of treatments.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.2142

EV1158

Schizophrenia spectrum disorders:

Focus on social cognition and

empathy

C. Gramaglia

1 ,

, E. Gattoni

1

, G. Giovanna

1

, S. Gili

1

, A. Feggi

1

,

V. Binda

2

, P. Prosperini

2

, P. Zeppegno

1

1

University of Eastern Piedmont, Traslational Medicine, Novara, Italy

2

AOU “Maggiore della Carità”, S.C. Psichiatria, Novara, Italy

Corresponding author.