European Psychiatry - Volume 33 - March 2016

736 / 812

S732 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805
Wahlbeck K, Cheine M, Essali A, Adams C. Evidence of clozapine’s
effectiveness in schizophrenia: a systematic review and meta-
analysis of randomized trials. Am J Psychiatry;156:990–9.
EV1199
Timing and chronometric counting in
patients with first episode of
schizophrenia and schizophrenia
spectrum disorders
Y. Zaytseva ∗, Z. Garakh , J. Horacek , M. Wittmann
1 National Institute of Mental Health, National IT System of Mental
Health and Brain Monitoring, Klecany/Prague, Czech Republic
2 Institute of Higher Nervous Activity and Neurophysiology Russian
Academy of Science, Psychophysiology, Moscow, Russia
3 Institute for Frontier Areas of Psychology and Mental Health,
Freiburg, Germany
∗ Corresponding author.
Background The ability to encode time intervals underlies var-
ious cognitive processes. In the light of compromised cognitive
functions in schizophrenia patients, it is noteworthy that there
are numerous reports indicating impaired timing abilities of these
patients. The aimof the present studywas to investigate if such tim-
ing disruptions are similarly present in patients with first episode
of schizophrenia spectrum disorders (SSD).
Methods Time reproduction paradigm was administered in
patients with first episode psychoses with the diagnoses of
paranoid schizophrenia (n = 43); schizoaffective disorder (n = 33);
schizotypal disorder (n = 31) and healthy individuals (n = 94). Par-
ticipants reproduced time durations of 10, 20, 15 and 25 s. by
pressing the mouse’s button at the beginning and at the end of the
interval with the supposed duration. The ratio between the real
time interval duration and produced time interval duration was
estimated (= 1-norm, > 1-overestimation, < 1-underestimation).
Results All participants used counting as a strategy for repro-
duction of the intervals. In healthy individuals, we observed an
increasing accuracy (values close to 1) with each trial. The per-
formance of patients differed significantly from controls [F(12,
508.28) = 3.46, P = 0.013].While patientswith schizophrenia signifi-
cantly overestimated the time durations, patients with schizotypal
disorder demonstrated marked underestimation (Fig. 1). Patients
with schizoaffective disorder performed close to norm.
Conclusions Our results suggest that patients with first episode
of schizophrenia and SSD are less accurate at estimating time
durations but in a various ways, possibly underlying distinct neu-
robiological mechanisms of timing disruptions.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1200
A case of somatopsychic
depersonalization in schizotypal
disorder: A multimodal approach
Y. Zaytseva ∗ Wittmann
1 National Institute of Mental Health, National IT System of Mental
Health and Brain Monitoring, Klecany/Prague, Czech Republic
2 Institute for Frontier Areas of Psychology and Mental Health,
Freiburg, Germany
∗ Corresponding author.
Background In the general concept of self-disturbances in
schizophrenia and schizophrenia spectrum disorders, somatopsy-
chic depersonalization (SPD) occupies a special place, as it
constitutes a syndrome that comprises feelings of detachment
from one’s own body and mental processes. However, apart from
clinical descriptions, to date the pathophysiology of SPD is not fully
understood due to the rareness of the syndrome and a lack of exper-
imental studies.
Methods In a case study of one patient with schizotypal dis-
order (M.M., male, 29 y.o.), we applied a multimodal evaluation
(phenomenological, neuropsychological, behavioural, application
of fMRI paradigm) in order to understand the SPD phenomena.
Results The patient’s clinical profile was identified as disruption
of implicit bodily function, accompanied by depressive symptoms.
On a neuropsychological level, the patient exhibited impairment
in executive functioning, intact tactile perception and kinesthetic
praxis. Behavioral tests revealed an altered sense of time but
unimpaired self-agency. Furthermore, the patient exhibited a lack
of empathy and he had autistic traits, although with a suffi-
cient ability to verbalize his feelings. On the neurobiological level
using an active and passive touch paradigm during functional
magnetic resonance imaging (fMRI), we found a hyperconnec-
tivity of the default-mode network and salience network and a
hypoconnectivity of the central executive brain networks in the
performance of the touch task as well as intact perceptual touch
processing emerging from the direct comparisons of the touch
conditions.
Conclusions Our data provide evidence for the important role of
altered large-brain network functioning in SPD that corresponds to
the specific behavioral and neurocognitive phenomena.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
Sexual disorders
EV1201
A journey across perversions history –
from Middle Age to DSM
A. Amaral∗ erraz , M. Mota
Centro Hospitalar de São João, Psychiatry and Mental Health Clinic,
Porto, Portugal
∗ Corresponding author.
Introduction Psychiatry’s viewpoint of sexual deviance has
waved between the normal and the pathological. “Normal” is not
determined by nature but by the values of a specific society.
Aims To review the main landmarks in paraphilias history and
the importance of social and cultural dimensions to it.
Methods PubMed database was searched using the keywords
perversion, sexual deviance, paraphilia, culture and society.
Results Throughout Middle Age and Renaissance any sexual
act that differed from the natural/divine law was considered
a vice. Unnatural vices (masturbation, sodomy, bestiality) were
the most severely punished, as they could not result in con-
ception. In 1886, Krafft-Ebing stated perversions were functional
diseases of the sexual instinct caused by “hereditary taintedness”
in the family pedigree and worsened by excessive masturbation.
Proper perversions were sadism, masochism, antipathic sexual-
ity (homosexuality, transvestism, transsexuality) and fetishism.
Later, Havelock Ellis and Hirschfeld claimed sexual interest in the
population followed a statistical norm, opposed the idea that mas-
turbation led to diseases and demanded the decriminalization of
homosexuality. Freud believed the “perverse disposition” to be uni-
versal in the childhood giving rise to healthy and pathological adult
behaviors. In 1950’s, Albert Kinsey surprised America when he
proved many supposedly deviant sexual practices were quite com-
mon. The first Diagnostic and Statistical Manual (1952) was mainly
psychoanalytic. Later, by 1973, homosexuality was removed from