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S732

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

Wahlbeck K, Cheine M, Essali A, Adams C. Evidence of clozapine’s

effectiveness in schizophrenia: a systematic review and meta-

analysis of randomized trials. Am J Psychiatry;156:990–9.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.2183

EV1199

Timing and chronometric counting in

patients with first episode of

schizophrenia and schizophrenia

spectrum disorders

Y. Zaytseva

1 ,

, Z. Garakh

2

, J. Horacek

1

, M. Wittmann

3

1

National Institute of Mental Health, National IT System of Mental

Health and Brain Monitoring, Klecany/Prague, Czech Republic

2

Institute of Higher Nervous Activity and Neurophysiology Russian

Academy of Science, Psychophysiology, Moscow, Russia

3

Institute for Frontier Areas of Psychology and Mental Health,

Freiburg, Germany

Corresponding author.

Background

The ability to encode time intervals underlies var-

ious cognitive processes. In the light of compromised cognitive

functions in schizophrenia patients, it is noteworthy that there

are numerous reports indicating impaired timing abilities of these

patients. The aimof the present studywas to investigate if such tim-

ing disruptions are similarly present in patients with first episode

of schizophrenia spectrum disorders (SSD).

Methods

Time reproduction paradigm was administered in

patients with first episode psychoses with the diagnoses of

paranoid schizophrenia (

n

= 43); schizoaffective disorder (

n

= 33);

schizotypal disorder (

n

= 31) and healthy individuals (

n

= 94). Par-

ticipants reproduced time durations of 10, 20, 15 and 25 s. by

pressing the mouse’s button at the beginning and at the end of the

interval with the supposed duration. The ratio between the real

time interval duration and produced time interval duration was

estimated (= 1-norm, > 1-overestimation, < 1-underestimation).

Results

All participants used counting as a strategy for repro-

duction of the intervals. In healthy individuals, we observed an

increasing accuracy (values close to 1) with each trial. The per-

formance of patients differed significantly from controls [F(12,

508.28) = 3.46,

P

= 0.013].While patientswith schizophrenia signifi-

cantly overestimated the time durations, patients with schizotypal

disorder demonstrated marked underestimation (Fig. 1). Patients

with schizoaffective disorder performed close to norm.

Conclusions

Our results suggest that patients with first episode

of schizophrenia and SSD are less accurate at estimating time

durations but in a various ways, possibly underlying distinct neu-

robiological mechanisms of timing disruptions.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.2184

EV1200

A case of somatopsychic

depersonalization in schizotypal

disorder: A multimodal approach

Y. Zaytseva

1 ,

, M .

Wittmann

2

1

National Institute of Mental Health, National IT System of Mental

Health and Brain Monitoring, Klecany/Prague, Czech Republic

2

Institute for Frontier Areas of Psychology and Mental Health,

Freiburg, Germany

Corresponding author.

Background

In the general concept of self-disturbances in

schizophrenia and schizophrenia spectrum disorders, somatopsy-

chic depersonalization (SPD) occupies a special place, as it

constitutes a syndrome that comprises feelings of detachment

from one’s own body and mental processes. However, apart from

clinical descriptions, to date the pathophysiology of SPD is not fully

understood due to the rareness of the syndrome and a lack of exper-

imental studies.

Methods

In a case study of one patient with schizotypal dis-

order (M.M., male, 29 y.o.), we applied a multimodal evaluation

(phenomenological, neuropsychological, behavioural, application

of fMRI paradigm) in order to understand the SPD phenomena.

Results

The patient’s clinical profile was identified as disruption

of implicit bodily function, accompanied by depressive symptoms.

On a neuropsychological level, the patient exhibited impairment

in executive functioning, intact tactile perception and kinesthetic

praxis. Behavioral tests revealed an altered sense of time but

unimpaired self-agency. Furthermore, the patient exhibited a lack

of empathy and he had autistic traits, although with a suffi-

cient ability to verbalize his feelings. On the neurobiological level

using an active and passive touch paradigm during functional

magnetic resonance imaging (fMRI), we found a hyperconnec-

tivity of the default-mode network and salience network and a

hypoconnectivity of the central executive brain networks in the

performance of the touch task as well as intact perceptual touch

processing emerging from the direct comparisons of the touch

conditions.

Conclusions

Our data provide evidence for the important role of

altered large-brain network functioning in SPD that corresponds to

the specific behavioral and neurocognitive phenomena.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.2185

Sexual disorders

EV1201

A journey across perversions history –

from Middle Age to DSM

A. Amaral

, I. F

erraz , M. Mota

Centro Hospitalar de São João, Psychiatry and Mental Health Clinic,

Porto, Portugal

Corresponding author.

Introduction

Psychiatry’s viewpoint of sexual deviance has

waved between the normal and the pathological. “Normal” is not

determined by nature but by the values of a specific society.

Aims

To review the main landmarks in paraphilias history and

the importance of social and cultural dimensions to it.

Methods

PubMed database was searched using the keywords

perversion, sexual deviance, paraphilia, culture and society.

Results

Throughout Middle Age and Renaissance any sexual

act that differed from the natural/divine law was considered

a vice. Unnatural vices (masturbation, sodomy, bestiality) were

the most severely punished, as they could not result in con-

ception. In 1886, Krafft-Ebing stated perversions were functional

diseases of the sexual instinct caused by “hereditary taintedness”

in the family pedigree and worsened by excessive masturbation.

Proper perversions were sadism, masochism, antipathic sexual-

ity (homosexuality, transvestism, transsexuality) and fetishism.

Later, Havelock Ellis and Hirschfeld claimed sexual interest in the

population followed a statistical norm, opposed the idea that mas-

turbation led to diseases and demanded the decriminalization of

homosexuality. Freud believed the “perverse disposition” to be uni-

versal in the childhood giving rise to healthy and pathological adult

behaviors. In 1950’s, Albert Kinsey surprised America when he

proved many supposedly deviant sexual practices were quite com-

mon. The first

Diagnostic and Statistical Manual

(1952) was mainly

psychoanalytic. Later, by 1973, homosexuality was removed from