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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

S579

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1700

EV716

Serine racemase in inhibitory neurons

at striatum and it might be involved

in schizophrenia’s pathophysiology

with D1 and D2 receptors

S. Takagi

1 ,

, D. Balu

2

, J. Coyle

2

1

Tokyo Medical and Dental University, Psychiatry, Tokyo, Japan

2

Harvard Medical School, Department of Psychiatry, Boston, USA

Corresponding author.

Introduction

There is substantial evidence that hypofunction of

the

N

-methyl-

d

-aspartate receptor (NMDAR) is a core pathophysi-

ological mechanism underlying schizophrenia.

d

-serine and serine

racemase (SR) (NMDAR co-agonist and it’s producer) are thought

to be involved in schizophrenia’s pathophysiology as NMDAR func-

tion moderators. Our laboratory showed that excitatory neuron

specific SR knock out (SRKO) mice still have just 50% reduction of

SR whereas full SRKOmice had no SR. Furthermore

d

-serine and SR

are found in inhibitory neurons not only in excitatory neurons with

immunohistochemistry methods. Because NMDAR has excitatory

functions, the existence of

d

-serine and SR in inhibitory neurons

and their functions are of interest.

Aims

To elucidate the existence and roles of

d

-serine and SR in

inhibitory neurons.

Methods

Inhibitory neuron marker, GAD65, specific conditional

SRKO (GAD65 SRKO) mice were made by Cre-lox recombina-

tion method. The GAD65 SRKO mice were analyzed by HPLC

for

d

-serine concentration, western blotting for SR expression,

immunohistochemistry for SR positive cell’s character identifica-

tion and behavioral testing.

Results

GAD65 SRKO had about 50% reduction of SR in striatum

but no reduction in hippocampus and frontal cortex.

d

-serine of

GAD65 SRKO mice was not different fromWT mice. Immunohisto-

chemistryworks revealed SR is inmediumspiny neuron of striatum

and has colocalization with DARRP-32, D1 receptor, and D2 recep-

tor.

Conclusions

SR is expressed in inhibitory neurons at least in

striatum. It might be involved in schizophrenia’s pathophysiology

because it colocalizes with D1 and D2 receptors.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1701

Geriatric psychiatry

EV717

Catatonia and dementia

M. Almeida

, C. G

ama Pereira

Centro Hospitalar Baixo Vouga, Departamento de Psiquiatria e Saúde

Mental, Aveiro, Portugal

Corresponding author.

Introduction

Catatonia, described by Kahlbaum in 1874, is usu-

ally seen as a type of schizophrenia, but it can also occur in a wide

range of other psychiatric/organic disturbances. There is a docu-

mented association between dementia and catatonia, in all phases

of cognitive impairment.

Aims

Literature review and discussion about Catatonia, regard-

ing a case report.

Methods

Clinical interviews and literature review in PUBMED

database.

Results (case report)

Female patient, 89 years old, without psy-

chiatric history, was diagnosed with dementia 5 months prior to

episode. On admission, she presents with prostration, mutism and

refusal to eat/drink. Laboratory studies were normal and TC-CE

shows signs of an old stroke in left temporo-parietal region and

diffuse signs of ischemic leucoencephalopathy. At psychiatric eval-

uation, she was stuporous, unreactive to pain, mute, not following

verbal commands, keeping her eyes closed and resisting attempts

to open her eyelids. She had global rigidity, axial and limbs, and

maintains the postures the examiner puts her into for long peri-

ods. She was already given chlorpromazine, without improvement.

Then she takes diazepam 10mg iv, with remission of the state.

Conclusions

Although catatonia usually presents with drama,

clinicians often forget to consider it in differential diagnosis, prob-

ably because of its traditional association with schizophrenia. A

promptly diagnostic is crucial to provide adequate treatment,

avoiding drugs that can worsen/perpetuate the clinical state. Some

authors even support the idea that motor features associated

with end-line dementias may correspond to lorazepam-responsive

catatonia, in which treatment may have a tremendous impact

worldwide.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1702

EV718

Mini-Mental State (MMS) evaluation

of dementia in psychiatric patients

admitted to a long stay ward

N. Amel

, L.P. Isabelle , G. Aurelie , H. Marc , A. Mohammed ,

I. Ziad

USLD La Roseraie, EPS Maison-blanche, Seine-Saint-Denis,

Neuilly-Sur-Marne, France

Corresponding author.

Normal 0 21 false false false FR X-NONE X-NONE MicrosoftInterne-

tExplorer4.

MMS scores for 41 psychiatric patients were analyzed at admission

and regularly throughout their stay.

Results

Their average age at admission was 65.7. Thirty-six

patients had a diagnosis of chronic psychosis, two with bipolar

disorders, one with frontotemportal dementia, two with Korsakoff

syndrome.

At admission, 21 (51%) patientsshowed mild cognitive deteriora-

tion (score = 18–26), 12 (29%) moderate deterioration (12–17), 6

severe deterioration (0–11), 2 had normal scores (27–30). Over the

following years, 28 patients were reassessed:

– 12 (42%) were stable, 7 (25%) had a fluctuating score, 5 (18%)

improved;

– 4 (14%) deteriorated over their successive MMS evaluations;

– age, socio-cultural level and psychiatric diagnosis were not asso-

ciated with change in MMS scores;

– average change between initial and final assessment was +6.0

points for patients with improved score, –7.75 for those showing

deterioration;

– 1.28 for those with fluctuating scores, –1.0 for stable patients.

Analysis

Unstable psychiatric disorders associated with somatic

pathologies influenced MMS scores for all patients, particularly

for those with MMS deterioration or fluctuation even if this phe-

nomenon could also be observed to a lesser extent in stable

patients. By contrast, patients whose MMS scores improved over

time were more mentally stable and had no current somatic prob-

lems. Multidisciplinary teamwork is important for patients with

deteriorating MMS scores.

Conclusion

By illustrating the impact of somatic and psychiatric

factors on dementia, the present study underlines the value of