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S30

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S18–S55

S37

Introducing PEEP: The psychiatry

early experience programme

H. Qureshi

1 ,

, C. Holt

2

, R. Mirvis

3

, S. Cross

4

, O. Hussain

5

,

H. Hutchings

6

, E. Marshall

7

, F. Turner

8

,

C. Wilson Jones (Director of Undergraduate Psychiatry)

9

1

South London and Maudsley NHS Foundation Trust, Lewisham IPTT

Ladywell Clinic, London, United Kingdom

2

South London and Maudsley NHS Foundation Trust, Southwark

Community Mental Health team Older Adults, London, United

Kingdom

3

Oxleas NHS Foundation Trust, Greenwich Learning Disability Team,

London, United Kingdom

4

Oxleas NHS Foundation Trust, Greenwich East ICMP, London, United

Kingdom

5

South London and Maudsley NHS Foundation Trust, Mental Health

of Older Adults, London, United Kingdom

6

South London and Maudsley NHS Foundation Trust, National

Autism Unit, Beckenham, United Kingdom

7

South London and Maudsley NHS Foundation Trust, Wandsworth

Community Drug and Alcohol Team, London, United Kingdom

8

Oxleas NHS Foundation Trust, Adult Mental Health, London, United

Kingdom

9

South London and Maudsley NHS Foundation Trust, London, United

Kingdom

Corresponding author.

At Guy’s King’s and St Thomas’ School of Medicine, a unique initia-

tive is the Psychiatry Early Experience Programme (PEEP), which

allows students to shadow psychiatry trainees at work several

times a year. The students’ attitudes towards psychiatry and the

scheme are regularly assessed and initial results are already avail-

able.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.853

Epigenetic discoveries in psychiatric disorders

S38

Methylome modifications in

monozygotic twins and in depression

L. Fa˜nanás

, A. Córdova-Palomera

University of Barcelona, Animal Biology, Barcelona, Spain

Corresponding author.

Epigenetics is the study of gene expression changes that are pro-

duced by heritable, though potentially reversible, modifications of

chromatin structure or DNAmethylation. DNAmethylation is inter-

esting in epidemiological studies, due to its accessibility and since

previous evidence indicates that large inter-individual differences

in methylation levels at some loci may correlate with phenotypic

plasticity in changing environments.

Prior genome-wide methylomic research on depression has sug-

gested that, together with differential DNA methylation changes,

affected co-twins of monozygotic twin pairs have increased DNA

methylation variability, probably in line with theories of epige-

netic stochasticity. However, the putative biological roots of this

variability remain largely unexplored.

This study evaluate whether DNA methylation differences within

MZ twin pairs were related to differences in their depressive status.

Genome-wide DNA methylation levels were measured in periph-

eral blood of 34 twins (17MZ pairs) using Illumina InfiniumHuman

Methylation450 Beadchip. Two analytical strategies were used

to identify differentially methylated probes (DMPs) and variably

methylated probes (VMPs).

The majority of the DMPs were located in genes previously related

to neuropsychiatric phenotypes, such as WDR26, a GWAS hit for

MDD whose expression levels have been found altered in blood of

depressed individuals.

VMPs were located in genes such as

CACNA1C

,

IGF2

and the p38

MAP kinase

MAPK11

, showing enrichment for biological processes

such as glucocorticoid signaling.

The findings expand on previous research to indicate that both

differential and variable methylation may play a role in the

etiopathology of depression, and suggest specific genomic loci of

potential interest in the epigenetics of depression.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.854

S39

Longitudinal study of methylome

profiles in subjects with psychosis

and/or schizophrenia

O. Kebir

, B. Chaumette , M.O. Krebs

Inserm U894, Centre of Psychiatry and Neurosciences, Paris, France

Corresponding author.

Background

Schizophrenia is a complex disorder involving both

genetic and environmental factors. Epigenetic is a growing theory

to explain these interactions at a molecular level. It is well-

known that schizophrenia begins with prodromal symptoms and

patients undergoing subthreshold symptoms are named ultra-high

risk (UHR) subjects. Therapeutic and prognostic attitude remain

challenging for this population. According to themodel of the gene-

environment interactions, the psychotic transition in adolescence

could be related to epigenetic changes during the psychotic transi-

tion.

Methods

We designed and performed the first longitudinal study

about whole-genome DNA methylation changes. Thirty-nine UHR

patients were recruited in specialized center C’JAAD - Centre

Hospitalier Ste Anne - Paris (France). During follow-up, 14 of

them became psychotic (converters) according to the validated

scale CAARMS. Initial and final methylation were investigated by

Infinium Human Methylation450 BeadChip for 450,000 CpG after

bisulfite conversion.

Results

The psychotic transition was not associated with global

methylation changes. Linear models failed to identify CpG and

genes significantly associated with psychotic transition after Bon-

ferroni correction. Analyses of the top results provided a cluster,

which could classify perfectly converters and non-converters.

These genes of interest are over-represented in biological pathways

with relevance for psychotic physiopathology. Individual analyses

highlighted the biological heterogeneity of the psychotic transition.

Conclusion

Improving physiopathological understanding of psy-

chotic transition is a current challenge to identify biomarkers and

to develop targeted preventive interventions available in clinical

practice for UHR subjects. The epigenetic processes and in particu-

lar DNA methylation could be interesting factors.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.855

S40

Epigenetic modifications in anorexia

nervosa patients and remitters

compared to healthy control women

N. Ramoz

1 ,

, J. Clarke

1 , 2

, P. Gorwood

1 , 3

1

Inserm U894, Centre de Psychiatrie et Neurosciences, Paris, France