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S32

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S18–S55

pharmacists, journalists) (level 3), and support for self-help

of patients with depression and for their relatives (level 4). In

order to deepen the understanding of factors influencing the

effectiveness of the intervention, a systematic implementation

research and process analysis was performed within the EU-

funded study “Optimizing Suicide Prevention Programs and Their

Implementation in Europe”

( http://www.ospi-europe.com/

; 7th

Framework Programme)

[5] .

These analyses were based on data

from four intervention and four control regions from four European

countries. In addition to intervention effects on suicidal behaviour,

a variety of intermediate outcomes (e.g. changes in attitude or

knowledge in different populations) were considered. Strong

synergistic as well as catalytic effects were identified as a result

of being active simultaneously at four different levels. Predictable

and unpredictable obstacles to a successful implementation of

such community-based programs will be discussed. Via the EAAD,

the intervention concept and materials (available in eight different

languages) are offered to interested region in and outside of Europe.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

References

[1] Hegerl, et al. Psychol Med 2006;36:1225–34.

[2] Hegerl, et al. Eur Arch Psychiatry ClinNeurosci 2010;260:401–6.

[3] Székely, et al. PLOS One 2013 [in press].

[4] Hübner-Liebermann, et al. GenHosp Psychiatry 2010;32:514–8.

[5] Hegerl, et al. Neurosci Biobehav Rev 2013 [pii: S0149-

7634(13)00045].

http://dx.doi.org/10.1016/j.eurpsy.2016.01.858

Hallucinations and delusions in schizophrenia:

From phenomenology to neurobiology

S43

Hallucinations without delusions in

patients with first-episode psychosis:

Clinical correlates and implications

for pathophysiological models

I. Melle

NORMENT Centre for Psychosis Research, Division of Mental Health

and Addiction, Institute of Clinical Medicine, University of Oslo and

Oslo University Hospital, Oslo, Norway

Introduction

The symptomatic distribution in schizophrenia

spectrum disorder is heterogeneous. Patients may experience hal-

lucinations, delusions and combinations thereof, in addition to

disorganized and negative symptoms. We have previously found

that patients with monosymptomatic hallucinations exhibited a

different clinical profile than patients with monosymptomatic

delusions or combinations of the two; with an earlier age at onset

and more suicidal symptoms.

Aims

To replicate findings in a new group of patients with

schizophrenia spectrum disorders.

Methods

A total of 421 consecutive patients with schizophre-

nia spectrum disorders were included into the study. They were

comprehensively assessed by specifically trained psychiatrists or

clinical psychologists; using the SCID for DSM-IV for diagnostic pur-

poses, the PANSS to assess current clinical symptoms and CDSS to

assess current depression. Lifetime presence of different symptom

types was ascertained during the diagnostic interview.

Results

A total of 346 (82%) had experienced both hallucina-

tions and delusion, 63 (15%) had experienced delusions without

hallucinations, 10 (2.5%) had experienced hallucinations without

delusions and 2 patients (0.5%) had neither but experienced nega-

tive and severely disorganized symptoms. Contrary to hypothesis,

we did not find any statistically significant differences in age at

onset and in clinical symptoms (including suicidality) between

these groups. We also did not find any differences in the type of

hallucinatory experiences between hallucinating groups.

Conclusions

In a new sample of patients, we did not replicate

previous findings of a different clinical profile in patients with

monosymptomatic hallucinations. This type of psychotic disorder

is relatively rare, whichmight pose a problemconcerning statistical

strength.

Disclosure of interest

The author has not supplied his declaration

of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.859

S44

Abnormal time experience, bizarre

delusions and verbal-acoustic

hallucinations in schizophrenia

G. Stanghellini

“G. d’Annunzio” University, Department of Psychological,

Humanistic and Territorial Sciences, Chieti, Italy

The integrity of time consciousness is the condition of possibility

of the identity through time of an object of perception as well as of

the personwho perceives it. I will present our findings about abnor-

mal time experience (ATE) in peoplewith schizophrenia. These data

may support the following hypothesis: if the continuity of temporal

experience disintegrates (of which ATE are experiential manifes-

tations), overarching meaningful units are no longer available,

thereby creating temporal gaps, e.g., in one’s stream of conscious-

ness. In some cases, thoughts that are no longer experienced as

embedded in one’s stream of thoughts are experienced as, e.g.,

thought interferences, blockages, insertion or withdrawal. These

symptoms cannot be explained as a mere disturbance of attention

or comprehension at the level of semantic combinations. Rather,

the disturbance could be searched for at a more basic level where

the temporal coherence of conscious awareness is constituted. A

failure of the constitutive temporal synthesis may create micro-

gaps of conscious experience. In the most severe cases, thoughts

or other mental phenomena that are no longer embedded in the

continuity of basic self-experience may appear in consciousness as

“erratic blocks” and experienced as being inserted, or, if further

externalized, as auditory hallucinations (“voices”). This coheres

with the hypothesis that a breakdown of temporalitymay be bound

up with the breakdown of prereflexive self-awareness.

Disclosure of interest

The author has not supplied his declaration

of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.860

Improving clinical outcomes through technology:

An innovative approach proposal

S45

Smartphone based treatment in

bipolar disorder

M. Faurholt-Jepsen

1 ,

, M .

Frost

2 , J.E.

Bardram

3 , L.V

. Kessing

1

1

Rigshospitalet, Copenhagen University Hospital, Psychiatric Center

Copenhagen, Copenhagen, Denmark

2

IT University of Copenhagen, PIT Laboratory, Copenhagen, Denmark

3

DTU, CACHET, Lyngby, Denmark

Corresponding author.

E-mental health technologies are under great development and the

use is of these technologies is increasing rapidly.