European Psychiatry - Volume 33 - March 2016

36 / 812

S32 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S18–S55
pharmacists, journalists) (level 3), and support for self-help
of patients with depression and for their relatives (level 4). In
order to deepen the understanding of factors influencing the
effectiveness of the intervention, a systematic implementation
research and process analysis was performed within the EU-
funded study “Optimizing Suicide Prevention Programs and Their
Implementation in Europe” ; 7th
Framework Programme) These analyses were based on data
from four intervention and four control regions from four European
countries. In addition to intervention effects on suicidal behaviour,
a variety of intermediate outcomes (e.g. changes in attitude or
knowledge in different populations) were considered. Strong
synergistic as well as catalytic effects were identified as a result
of being active simultaneously at four different levels. Predictable
and unpredictable obstacles to a successful implementation of
such community-based programs will be discussed. Via the EAAD,
the intervention concept and materials (available in eight different
languages) are offered to interested region in and outside of Europe.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
References
[1] Hegerl, et al. Psychol Med 2006;36:1225–34.
[2] Hegerl, et al. Eur Arch Psychiatry ClinNeurosci 2010;260:401–6.
[3] Székely, et al. PLOS One 2013 [in press].
[4] Hübner-Liebermann, et al. GenHosp Psychiatry 2010;32:514–8.
[5] Hegerl, et al. Neurosci Biobehav Rev 2013 [pii: S0149-
7634(13)00045].
Hallucinations and delusions in schizophrenia:
From phenomenology to neurobiology
S43
Hallucinations without delusions in
patients with first-episode psychosis:
Clinical correlates and implications
for pathophysiological models
I. Melle
NORMENT Centre for Psychosis Research, Division of Mental Health
and Addiction, Institute of Clinical Medicine, University of Oslo and
Oslo University Hospital, Oslo, Norway
Introduction The symptomatic distribution in schizophrenia
spectrum disorder is heterogeneous. Patients may experience hal-
lucinations, delusions and combinations thereof, in addition to
disorganized and negative symptoms. We have previously found
that patients with monosymptomatic hallucinations exhibited a
different clinical profile than patients with monosymptomatic
delusions or combinations of the two; with an earlier age at onset
and more suicidal symptoms.
Aims To replicate findings in a new group of patients with
schizophrenia spectrum disorders.
Methods A total of 421 consecutive patients with schizophre-
nia spectrum disorders were included into the study. They were
comprehensively assessed by specifically trained psychiatrists or
clinical psychologists; using the SCID for DSM-IV for diagnostic pur-
poses, the PANSS to assess current clinical symptoms and CDSS to
assess current depression. Lifetime presence of different symptom
types was ascertained during the diagnostic interview.
Results A total of 346 (82%) had experienced both hallucina-
tions and delusion, 63 (15%) had experienced delusions without
hallucinations, 10 (2.5%) had experienced hallucinations without
delusions and 2 patients (0.5%) had neither but experienced nega-
tive and severely disorganized symptoms. Contrary to hypothesis,
we did not find any statistically significant differences in age at
onset and in clinical symptoms (including suicidality) between
these groups. We also did not find any differences in the type of
hallucinatory experiences between hallucinating groups.
Conclusions In a new sample of patients, we did not replicate
previous findings of a different clinical profile in patients with
monosymptomatic hallucinations. This type of psychotic disorder
is relatively rare, whichmight pose a problemconcerning statistical
strength.
Disclosure of interest The author has not supplied his declaration
of competing interest.
S44
Abnormal time experience, bizarre
delusions and verbal-acoustic
hallucinations in schizophrenia
G. Stanghellini
“G. d’Annunzio” University, Department of Psychological,
Humanistic and Territorial Sciences, Chieti, Italy
The integrity of time consciousness is the condition of possibility
of the identity through time of an object of perception as well as of
the personwho perceives it. I will present our findings about abnor-
mal time experience (ATE) in peoplewith schizophrenia. These data
may support the following hypothesis: if the continuity of temporal
experience disintegrates (of which ATE are experiential manifes-
tations), overarching meaningful units are no longer available,
thereby creating temporal gaps, e.g., in one’s stream of conscious-
ness. In some cases, thoughts that are no longer experienced as
embedded in one’s stream of thoughts are experienced as, e.g.,
thought interferences, blockages, insertion or withdrawal. These
symptoms cannot be explained as a mere disturbance of attention
or comprehension at the level of semantic combinations. Rather,
the disturbance could be searched for at a more basic level where
the temporal coherence of conscious awareness is constituted. A
failure of the constitutive temporal synthesis may create micro-
gaps of conscious experience. In the most severe cases, thoughts
or other mental phenomena that are no longer embedded in the
continuity of basic self-experience may appear in consciousness as
“erratic blocks” and experienced as being inserted, or, if further
externalized, as auditory hallucinations (“voices”). This coheres
with the hypothesis that a breakdown of temporalitymay be bound
up with the breakdown of prereflexive self-awareness.
Disclosure of interest The author has not supplied his declaration
of competing interest.
Improving clinical outcomes through technology:
An innovative approach proposal
S45
Smartphone based treatment in
bipolar disorder
M. Faurholt-Jepsen ∗ Frost Bardram . Kessing
1 Rigshospitalet, Copenhagen University Hospital, Psychiatric Center
Copenhagen, Copenhagen, Denmark
2 IT University of Copenhagen, PIT Laboratory, Copenhagen, Denmark
3 DTU, CACHET, Lyngby, Denmark
∗ Corresponding author.
E-mental health technologies are under great development and the
use is of these technologies is increasing rapidly.