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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

S275

Objectives

The primary goal was to evaluate safety and efficacy of

rTMS in treatment-resistant schizophrenia patients with dominant

depressive and negative symptoms in open non-controlled trial.

Aims and patients

Thirty-one schizophrenia (ICD-10) patients

with evident depression (CDSS

6) and negative symptoms and

with stable low rate positive symptoms on combined adequate

pharmacotherapy (antipsychotic + antidepressant), which have not

been changed for at least 6 weeks, were included to the study.

Methods

All patients received 15-Hz rTMS on the left dorsolat-

eral prefrontal cortex (100% intensity, 1800 pulses per session, 5

sessions per week, 15 sessions per course) with 8-shaped coil of

Neuro-MS/D stimulator (Neurosoft). The primary efficacy measure

was 50% CDSS score reduction after the 3rd week of treatment. The

secondary measures were weekly reduction rates for CDSS and for

PANSS negative syndrome scale.

Results

Twenty (64,5%) patients respond to rTMS. Final mean

CDSS score reduction was 55,2% (

P

= 0,000004), and mean PANSS

negative scale score reduction was 21,3% (

P

= 0,000012). Two

patients (6,5%) were excluded due to persistent headaches, no seri-

ous adverse events were observed.

Conclusions

rTMS is safe and effective strategy for the manage-

ment of treatment-resistant depression in schizophrenia and can

alleviate negative symptoms. Further sham-controlled studies are

needed.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.576

EW459

Long-term electrical stimulation of

bed nucleus of stria terminalis for

obsessive-compulsive disorder

S. Raymaekers

1 ,

, V. Kristof

1

, C. Bervoets

2

, L. Gabriëls

3

,

L. Luyten

4 , K. D

emyttenaere

1 , B. N

uttin

1

1

Catholic university of Leuven, neurosciences, Leuven, Belgium

2

University psychiatric centre of KU Leuven, pscyhiatry, Leuven,

Belgium

3

University psychiatric centre of KU Leuven, psychiatry, Leuven,

Belgium

4

Catholic university of Leuven, centre for psychology of learning and

experimental psychopathology, Leuven, Belgium

Corresponding author.

Introduction

We previously reported that deep brain stimulation

(DBS) in the anterior limb of the internal capsule/bed nucleus of the

stria terminalis (IC/BST) is effective in reducing symptoms in severe

treatment-resistant obsessive-compulsive disorder patients.

Objective

To examine the long-term evolution of obsessive com-

pulsive disorder (OCD) symptoms in 24 patients treated with

chronic electrical stimulation in IC/BST.

Aims

We aimed to examine the evolution of the Yale-Brown

Obsessive Compulsive Scale (Y-BOCS) and to determine if a num-

ber of predictors assessed before surgery are significantly related

to this evolution.

Methods

We used a linear mixed model to investigate the evo-

lution of the Y-BOCS in 24 patients. Data was collected in a

naturalistic manner. Seven hundred measurements, taken during a

total of 1836 follow-up months, are included in this analysis.

Results

Our analysis showed a long-term, sustained effect of

electrical stimulation in the IC/BST. After a fast initial decline of

OCD symptoms, these symptoms stay relatively stable. In addition,

results show a strong ON/OFF effect of stimulation (e.g., due to bat-

tery depletion). Beside the ON/OFF effect of stimulation, the surgery

itself has no additional effect on OCD symptoms. The Beck Depres-

sion Inventory (BDI) at baseline was the only predictor significantly

related to the evolution of the Y-BOCS. A higher BDI at baseline

seemed to be related to a smaller decrease of the Y-BOCS over time.

Conclusion

Electrical stimulation in the IC/BST has a fast and sus-

tained effect on OCD symptoms.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.577

EW460

Superficial neurostimulation

application, alpha rhythm and clinical

effects

P. Rico

1 ,

, P . A

ranguren

2

1

Universidad Alcala de Henares, medical specialities, Madrid, Spain

2

Universidad complutense, psychology, Madrid, Spain

Corresponding author.

Introduction

The alpha rhythm (EEG) in prefrontal regions has

been related with the emotional equilibrium, predisposition for

a positive mood (Urry et al., 2004) and the activation of the

approximation system (Davidson and Irwin, 1999). Superficial neu-

rostimulation application (SNSA) provokes an increase of such

rhythm in prefrontal and temporal areas (Bardasano et al., 2010).

Aims

To demonstrate that the increase of alpha synchronization

is a common factor in the satisfactory evolution of patients with

different pathologies.

Methods

Thirty patients with different symptoms (hostility,

anxiety, bruxism and obsessive symptoms) received 20 weekly

sessions of 45 minutes long using the SNSA.

Materials

–SNSA topology system: it is a machine for superfi-

cial stimulation that uses electricity through superficial electrodes

which are placed on feet and hands and an electrode over the 7th

cervical vertebra;

–digital encephalogram;

–Faraday cage.

Results

The alpha rhythm was incremented in 85% of the cases

in anterior regions of the brain, related with the improvement of

scale’s punctuation.

Conclusion

The alpha rhythmhas been showed to be presented in

all individuals that improved their symptoms after the application

of SNSA

( Fig. 1 ).

Fig. 1

Distribution of cranial calotte activity post-SNSA. 20th

session. Distribution of cranial

calotte activity pre-SNSA. 1st

session.