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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

S273

9-hydroxyrisperidone. These results propose that hyperprolactine-

mia may development during risperidone treatment.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.570

EW453

Efficacy and safety of long-term

cabergoline treatment of

antipsychotic-induced

hyperprolactinemia (naturalistic

study)

O. Yunilaynen

1 ,

, E. Starostina

2

, L. Dzeranova

1

, P. Baranov

3

,

I. Dedov

4

1

National research center for endocrinology, neuroendocrinology,

Moscow, Russia

2

Moscow regional clinical & research institute MONIKI,

endocrinology, Moscow, Russia

3

Russian medical academy of post-graduate training, psychiatry,

Moscow, Russia

4

National research center for endocrinology, diabetes center,

Moscow, Russia

Corresponding author.

Introduction

Antipsychotic-induced hyperpolactinemia (AIH) is

associated with disturbing clinical symptoms, such as sexual dys-

functions, menstrual disorders and galactorrhea. Long-termstudies

of dopamine agonists in AIH are scarce.

Objectives

To assess efficacy and safety of cabergoline use in psy-

chiatric patients with AIH, including impact on sexual function and

quality of life(QoL).

Methods

It was an open-labeled non-randomized naturalistic

prospective comparison of cabergoline vs n

о

treatment in 84

chronic psychiatric patients (F/M= 77/7) with AIH. Cabergoline

treatment was started in 44 patients, the control group included 40

patients who rejected the treatment with cabergoline. For assess-

ment of QoL, sexual dysfunction and other hyperprolactinemia

symptoms, UKU side effects rating scale (UKU) and SF-36 were

used.

Results

The main and control groups were comparable on

all main clinical and psychiatric characteristics. The effective

cabergoline dose was 0,25-3 (median-0,5) mg weekly; total caber-

goline exposure–534 patient-weeks. Normal prolactin levels were

achieved after 4-44 (median-14) weeks in 95% of patients. At

3 months after cabergoline discontinuation, prolactin remained

normal in 71%, and AIH recurred in 29% of patients. Prolactin

normalization was associated with significant reduction of men-

strual disorders, galactorrhea, improvement of UKU scores on

sexual desire, orgastic dysfunction, total UKU score and SF-36

scores on subscales of social functioning (

P

= 0,006), role-emotional

(

P

= 0,042), and mental health (

P

= 0,049). The rate of psychosis

exacerbation in control group was higher than in the treatment

group (37,5% vs 0%;

P

< 0,001).

Conclusions

Cabergoline is effective and safe in majority of AIH

patients. Long-term cabergoline treatment is not associated with

psychosis exacerbation. Beyond reversal of typical AIH symptoms,

treatment with cabergolin improves sexual function and QoL.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.571

Psychosurgery and stimulation methods (ECT,

TMS, VNS, DBS)

EW454

Electroconvulsive therapy in elderly -

a preliminary study

C. Agostinho

, M. Duarte , R. Alves , I. Cunha , A.M. Batista

Centro hospitalar psiquiátrico de Lisboa, Lisboa, Portugal

Corresponding author.

Introduction

Studies with electroconvulsive therapy (ECT) in

elderly focus mainly on the assessment of possible side effects on

the cognitive functioning; there are few studies that evaluate the

effectiveness.

Objective

Evaluate the effectiveness of this treatment in the pop-

ulation over 65 years.

Aims

Perform a preliminary study to evaluate the response to

ECT of

65 years patients with depression.

Methods

We carry out a descriptive study based on patients

treated in the last 10 years in the ECT Unit of Centro Hospitalar

Psiquiátrico de Lisboa.

Results

Our initial sample consisted of 457 patients. We select

patients aged

65 years with depression, and with complete data,

including electroconvulsive parameters, and initial andfinal Hamil-

ton Rating Scale for Depression (HRSD) scores (

n

= 59). Of this,

81.36% (

n

= 48) had unipolar depression, and 18.64% (

n

= 11) had

bipolar depression. In the first group, the mean variation between

the initial and final scores in HRSD was 13.88 points, and 27.10%

(

n

= 13) of the patients ended the treatment in the normal range of

HRSD score. In the second group, the mean variation was 12.82,

and 63.60% (

n

= 7) ended the treatment in the normal range of

HRSD. Considering the initial and final HRSD scores, it appears that

unipolar depression group presents higher values (severe depres-

sion) (

P

< 0.05). When we compare the mean variation between the

initial and final HRSD scores, we didn’t observe a statistically sig-

nificant difference between the two groups. There was a clinical

improvement in both.

Conclusions

The acute treatment with ECT appears to improve

depressive symptoms in bipolar and unipolar depression, when

considering an elderly population.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.572

EW455

Knowledge and attitude toward

repetitive transcranial magnetic

stimulation (rTMS) among

psychiatrists in Saudi Arabia

A. Alhadi

1 , 2 ,

, A. AlShiban

3

, M. Alomar

3

, O. Aljadoa

3

,

A. AlSayegh

3

, M. Jameel

3

1

King Saud university, department of psychiatry, Riyadh, Kingdom of

Saudi Arabia

2

King Saud university, SABIC psychological health research &

applications chair SPHRAC, Riyadh, Kingdom of Saudi Arabia

3

King Saud university, college of medicine, Riyadh, Kingdom of Saudi

Arabia

Corresponding author.

Introduction

Repetitive transcranial magnetic stimulation

(rTMS) is a new treatment, used for different psychotic disorders

mainly depression.

Objectives

Assessing knowledge and attitude toward rTMS

among psychiatrists in Saudi Arabia, and determining factors

affecting that.