European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348 S273
9-hydroxyrisperidone. These results propose that hyperprolactine-
mia may development during risperidone treatment.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW453
Efficacy and safety of long-term
cabergoline treatment of
antipsychotic-induced
hyperprolactinemia (naturalistic
study)
O. Yunilaynen ∗, E. Starostina , L. Dzeranova , P. Baranov ,
I. Dedov
1 National research center for endocrinology, neuroendocrinology,
Moscow, Russia
2 Moscow regional clinical & research institute MONIKI,
endocrinology, Moscow, Russia
3 Russian medical academy of post-graduate training, psychiatry,
Moscow, Russia
4 National research center for endocrinology, diabetes center,
Moscow, Russia
∗ Corresponding author.
Introduction Antipsychotic-induced hyperpolactinemia (AIH) is
associated with disturbing clinical symptoms, such as sexual dys-
functions, menstrual disorders and galactorrhea. Long-termstudies
of dopamine agonists in AIH are scarce.
Objectives To assess efficacy and safety of cabergoline use in psy-
chiatric patients with AIH, including impact on sexual function and
quality of life(QoL).
Methods It was an open-labeled non-randomized naturalistic
prospective comparison of cabergoline vs nо treatment in 84
chronic psychiatric patients (F/M= 77/7) with AIH. Cabergoline
treatment was started in 44 patients, the control group included 40
patients who rejected the treatment with cabergoline. For assess-
ment of QoL, sexual dysfunction and other hyperprolactinemia
symptoms, UKU side effects rating scale (UKU) and SF-36 were
used.
Results The main and control groups were comparable on
all main clinical and psychiatric characteristics. The effective
cabergoline dose was 0,25-3 (median-0,5) mg weekly; total caber-
goline exposure–534 patient-weeks. Normal prolactin levels were
achieved after 4-44 (median-14) weeks in 95% of patients. At
3 months after cabergoline discontinuation, prolactin remained
normal in 71%, and AIH recurred in 29% of patients. Prolactin
normalization was associated with significant reduction of men-
strual disorders, galactorrhea, improvement of UKU scores on
sexual desire, orgastic dysfunction, total UKU score and SF-36
scores on subscales of social functioning (P = 0,006), role-emotional
(P = 0,042), and mental health (P = 0,049). The rate of psychosis
exacerbation in control group was higher than in the treatment
group (37,5% vs 0%; P< 0,001).
Conclusions Cabergoline is effective and safe in majority of AIH
patients. Long-term cabergoline treatment is not associated with
psychosis exacerbation. Beyond reversal of typical AIH symptoms,
treatment with cabergolin improves sexual function and QoL.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
Psychosurgery and stimulation methods (ECT,
TMS, VNS, DBS)
EW454
Electroconvulsive therapy in elderly -
a preliminary study
C. Agostinho∗, M. Duarte , R. Alves , I. Cunha , A.M. Batista
Centro hospitalar psiquiátrico de Lisboa, Lisboa, Portugal
∗ Corresponding author.
Introduction Studies with electroconvulsive therapy (ECT) in
elderly focus mainly on the assessment of possible side effects on
the cognitive functioning; there are few studies that evaluate the
effectiveness.
Objective Evaluate the effectiveness of this treatment in the pop-
ulation over 65 years.
Aims Perform a preliminary study to evaluate the response to
ECT of ≥ 65 years patients with depression.
Methods We carry out a descriptive study based on patients
treated in the last 10 years in the ECT Unit of Centro Hospitalar
Psiquiátrico de Lisboa.
Results Our initial sample consisted of 457 patients. We select
patients aged ≥ 65 years with depression, and with complete data,
including electroconvulsive parameters, and initial andfinal Hamil-
ton Rating Scale for Depression (HRSD) scores (n = 59). Of this,
81.36% (n = 48) had unipolar depression, and 18.64% (n = 11) had
bipolar depression. In the first group, the mean variation between
the initial and final scores in HRSD was 13.88 points, and 27.10%
(n = 13) of the patients ended the treatment in the normal range of
HRSD score. In the second group, the mean variation was 12.82,
and 63.60% (n = 7) ended the treatment in the normal range of
HRSD. Considering the initial and final HRSD scores, it appears that
unipolar depression group presents higher values (severe depres-
sion) (P < 0.05). When we compare the mean variation between the
initial and final HRSD scores, we didn’t observe a statistically sig-
nificant difference between the two groups. There was a clinical
improvement in both.
Conclusions The acute treatment with ECT appears to improve
depressive symptoms in bipolar and unipolar depression, when
considering an elderly population.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW455
Knowledge and attitude toward
repetitive transcranial magnetic
stimulation (rTMS) among
psychiatrists in Saudi Arabia
A. Alhadi ∗, A. AlShiban , M. Alomar , O. Aljadoa ,
A. AlSayegh , M. Jameel
1 King Saud university, department of psychiatry, Riyadh, Kingdom of
Saudi Arabia
2 King Saud university, SABIC psychological health research &
applications chair SPHRAC, Riyadh, Kingdom of Saudi Arabia
3 King Saud university, college of medicine, Riyadh, Kingdom of Saudi
Arabia
∗ Corresponding author.
Introduction Repetitive transcranial magnetic stimulation
(rTMS) is a new treatment, used for different psychotic disorders
mainly depression.
Objectives Assessing knowledge and attitude toward rTMS
among psychiatrists in Saudi Arabia, and determining factors
affecting that.