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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

S743

The patients without the relapse history saw the content of greater

success in their dreams (

P

= 0/02). The group with a history of

relapse reported more non-verbal activity content including the

drug abuse and its related activities in their dreams (

P

= 0/003) and

reported more drug-related recreational facilities such as Vafoor (a

pipe for opium smoking) in their dreams (

P

= 0/03).

Conclusion

Our study showed that the frequency of non-verbal

activities that is associated with the drug abuse and related issues

reports a warning to relapse the drug abuse.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.2218

EV1234

Comparative effects of ziprasidone

and quetiapine on sleep physiology

measures in patients with major

depressive disorder

A. Miljatovic

Clinical Hospital Center “Zvezdara”, Psychiatric hospital, Belgrade,

Serbia

Background

Sleep complaints are reported in a large percent-

age of patients with major depressive disorder (MDD). While

subjective complaints of insomnia (problems falling asleep, fre-

quent awakenings during the night, early morning awakening or

nonrestorative sleep) represent the most common form of sleep

disorder, a subset of depressed patients report hypersomnia, typi-

cally associated with anergy, lethargy and fatigue. Quetiapine is an

atypical antipsychotic approved for the treatment of schizophrenia,

bipolar disorder and along with an antidepressant to treat major

depressive disorder. Ziprasidone was the fifth atypical antipsy-

chotic to gain approval (February 2001) in the United States.

Method

Patients (

n

-35) received initial baseline polysomnogra-

phy evaluations over 2 consecutive nights. Subjects were randomly

assigned to either quetiapine (50–100mg/day) or ziprasidone

(60–100mg/day) treatment. Foran 8 week double-blind, double-

dummy treatment trial.

Enrolled patients were required to meet the following criteria:

19–67 years of age with a DSM-IV diagnosis of MDD based on a

semistructured clinical interview, a score of

18 on the 21 item

Hamilton Rating scale for depression, and a score of > 4 on the 3-

HAM-D sleep items. Single-night polysomnogramswere conducted

at weeks 1, 2, and 8with depression ratings assessed at baseline and

weeks 1, 2, 3, 4, 6 and 8.

Conclusion

In particular, the prominent effects of quetiapine in

shortening sleep latency and increasing total sleep time suggest

that this medicament compound may be of particular benefit in

the treatment of depression associated with prominent insomnia.

The present findings demonstrating beneficial effects of quetiapine

on sleep physiology parameters in MDD patients with insomnia

. . .

Disclosure of interest

The author has not supplied his declaration

of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.2219

EV1235

Recurrent hypersomnia: Kleine-Levin

syndrome

L. Rodríguez Andrés

, A. R

odríguez Campos , L. Gallardo Borge ,

G. Isidro García , E. Mayor Toranzo

Hospital Clínico Universitario de Valladolid, Psychiatry, Valladolid,

Spain

Corresponding author.

Introduction

Kleine-Levin syndrome was first described by

Kleine in 1925 and elaborated on by Levi in 1936. It is an infrequent

syndrome that predominantly affects to teenagers, and boys are

four times more likely to be affected than girls. It is rare for

patients over 30 years although some cases have been reported.

Kleine-Levin syndrome is a recurrent hypersomnia characterized

by episodes of hypersomnia lasting for 2 days to 4 weeks associ-

ated with symptoms of hyperphagia, hypersexuality and cognitive

impairment. It can be accompanied by other abnormal behavior

such as aggression, personality changes and irritability. Deficits are

resolved between episodes.

Case report

It is presented the case report of a patient that suffers

fromrecurrent episodes of hypersomnia associatedwith hyperpha-

gia and abnormal behavior.

Electroencephalography

EEG demonstrates slowing of drowsi-

ness and a decrease in REM sleep. The test of multiple sleep latency

is abnormal and the rest of complementary test are normal.

Diagnosis

F51.1 Recurrent hypersomnia (Kleine-Levin syn-

drome) [307.44].

Discussion

Kleine-Levin syndrome is an intriguing, severe and

homogenous disease with no obvious cause or treatment. Treat-

ment is generally supportive. It should be considered in any

teenager presenting with recurrent episodes of hypersomnia con-

current with cognitive changes or disinhibition.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.2220

EV1236

The relation between sleep quality

and mental health in students of

Kashan University of Medical Sciences

Z. Sepehrmanesh

Kashan University of Medical Sciences, Kashan, Iran

Introduction

Sleep is one of the most essential biological cycles,

which have complex pattern. Sleep disorders have adverse effect

on social performance and mental health. Prevalence of sleep dis-

orders is increasing specially in young adult. Some groups like

University students have more sleep disorders. This study inves-

tigates relation between mental health and sleep quality in the

students.

Methods

This case-control study was conducted on dormitory

students of Kashan University of Medical Science from 2013 to

2014. Two hundred students were selected by randomized sam-

pling that included 100 cases (50%) with sleep disorder and 100

cases without sleep disorder. Three questionnaires were used,

include: demographic variables, Pittsburgh and GHQ question-

naires.

Results

The mean age of students with sleep disorder and with-

out sleep disorder was 22.61 and 22.35, respectively, which have

not significant difference. There was a significant relation between

general mental health, physical symptoms, anxiety and depres-

sion scales with sleep quality (

P

< 0.01). GHQ score was 31.52 in

cases with sleep disorder and 18.49 in cases without sleep dis-

order. Thirty-five percent of students with sleep disorder and 7%

of students without sleep disorder had suicidal thoughts. Suicidal

attempt ideas were 32% and 7% in people with sleep disorder and

without sleep disorder, respectively. There was significance rela-

tion between sleep disorder and suicidal thought and attempt (

P

value < 0.001).

Conclusion

Sleep quality have important role on different aspects

of mental health. Attention to improve sleep quality of dormitory

students is necessary for better mental health. Education about

sleep hygiene have essential role to improve mental health for

University students in dormitories.

Disclosure of interest

The author has not supplied his declaration

of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.2221