European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805 S743
The patients without the relapse history saw the content of greater
success in their dreams (P = 0/02). The group with a history of
relapse reported more non-verbal activity content including the
drug abuse and its related activities in their dreams (P = 0/003) and
reported more drug-related recreational facilities such as Vafoor (a
pipe for opium smoking) in their dreams (P = 0/03).
Conclusion Our study showed that the frequency of non-verbal
activities that is associated with the drug abuse and related issues
reports a warning to relapse the drug abuse.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1234
Comparative effects of ziprasidone
and quetiapine on sleep physiology
measures in patients with major
depressive disorder
A. Miljatovic
Clinical Hospital Center “Zvezdara”, Psychiatric hospital, Belgrade,
Serbia
Background Sleep complaints are reported in a large percent-
age of patients with major depressive disorder (MDD). While
subjective complaints of insomnia (problems falling asleep, fre-
quent awakenings during the night, early morning awakening or
nonrestorative sleep) represent the most common form of sleep
disorder, a subset of depressed patients report hypersomnia, typi-
cally associated with anergy, lethargy and fatigue. Quetiapine is an
atypical antipsychotic approved for the treatment of schizophrenia,
bipolar disorder and along with an antidepressant to treat major
depressive disorder. Ziprasidone was the fifth atypical antipsy-
chotic to gain approval (February 2001) in the United States.
Method Patients (n-35) received initial baseline polysomnogra-
phy evaluations over 2 consecutive nights. Subjects were randomly
assigned to either quetiapine (50–100mg/day) or ziprasidone
(60–100mg/day) treatment. Foran 8 week double-blind, double-
dummy treatment trial.
Enrolled patients were required to meet the following criteria:
19–67 years of age with a DSM-IV diagnosis of MDD based on a
semistructured clinical interview, a score of ≥ 18 on the 21 item
Hamilton Rating scale for depression, and a score of > 4 on the 3-
HAM-D sleep items. Single-night polysomnogramswere conducted
at weeks 1, 2, and 8with depression ratings assessed at baseline and
weeks 1, 2, 3, 4, 6 and 8.
Conclusion In particular, the prominent effects of quetiapine in
shortening sleep latency and increasing total sleep time suggest
that this medicament compound may be of particular benefit in
the treatment of depression associated with prominent insomnia.
The present findings demonstrating beneficial effects of quetiapine
on sleep physiology parameters in MDD patients with insomnia. . .
Disclosure of interest The author has not supplied his declaration
of competing interest.
EV1235
Recurrent hypersomnia: Kleine-Levin
syndrome
L. Rodríguez Andrés ∗ odríguez Campos , L. Gallardo Borge ,
G. Isidro García , E. Mayor Toranzo
Hospital Clínico Universitario de Valladolid, Psychiatry, Valladolid,
Spain
∗ Corresponding author.
Introduction Kleine-Levin syndrome was first described by
Kleine in 1925 and elaborated on by Levi in 1936. It is an infrequent
syndrome that predominantly affects to teenagers, and boys are
four times more likely to be affected than girls. It is rare for
patients over 30 years although some cases have been reported.
Kleine-Levin syndrome is a recurrent hypersomnia characterized
by episodes of hypersomnia lasting for 2 days to 4 weeks associ-
ated with symptoms of hyperphagia, hypersexuality and cognitive
impairment. It can be accompanied by other abnormal behavior
such as aggression, personality changes and irritability. Deficits are
resolved between episodes.
Case report It is presented the case report of a patient that suffers
fromrecurrent episodes of hypersomnia associatedwith hyperpha-
gia and abnormal behavior.
Electroencephalography EEG demonstrates slowing of drowsi-
ness and a decrease in REM sleep. The test of multiple sleep latency
is abnormal and the rest of complementary test are normal.
Diagnosis F51.1 Recurrent hypersomnia (Kleine-Levin syn-
drome) [307.44].
Discussion Kleine-Levin syndrome is an intriguing, severe and
homogenous disease with no obvious cause or treatment. Treat-
ment is generally supportive. It should be considered in any
teenager presenting with recurrent episodes of hypersomnia con-
current with cognitive changes or disinhibition.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1236
The relation between sleep quality
and mental health in students of
Kashan University of Medical Sciences
Z. Sepehrmanesh
Kashan University of Medical Sciences, Kashan, Iran
Introduction Sleep is one of the most essential biological cycles,
which have complex pattern. Sleep disorders have adverse effect
on social performance and mental health. Prevalence of sleep dis-
orders is increasing specially in young adult. Some groups like
University students have more sleep disorders. This study inves-
tigates relation between mental health and sleep quality in the
students.
Methods This case-control study was conducted on dormitory
students of Kashan University of Medical Science from 2013 to
2014. Two hundred students were selected by randomized sam-
pling that included 100 cases (50%) with sleep disorder and 100
cases without sleep disorder. Three questionnaires were used,
include: demographic variables, Pittsburgh and GHQ question-
naires.
Results The mean age of students with sleep disorder and with-
out sleep disorder was 22.61 and 22.35, respectively, which have
not significant difference. There was a significant relation between
general mental health, physical symptoms, anxiety and depres-
sion scales with sleep quality (P < 0.01). GHQ score was 31.52 in
cases with sleep disorder and 18.49 in cases without sleep dis-
order. Thirty-five percent of students with sleep disorder and 7%
of students without sleep disorder had suicidal thoughts. Suicidal
attempt ideas were 32% and 7% in people with sleep disorder and
without sleep disorder, respectively. There was significance rela-
tion between sleep disorder and suicidal thought and attempt (P
value < 0.001).
Conclusion Sleep quality have important role on different aspects
of mental health. Attention to improve sleep quality of dormitory
students is necessary for better mental health. Education about
sleep hygiene have essential role to improve mental health for
University students in dormitories.
Disclosure of interest The author has not supplied his declaration
of competing interest.