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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

S689

use of ECT with anesthesia, muscle relaxation and hardware anal-

ysis of the EEG in the Republic of Belarus may be effective against

drug-resistant forms of mental and behavioral disorders.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.2047

EV1063

A review of transcranial magnetic

stimulation for treating negative

symptoms of schizophrenia

J. Oliveira

1 ,

, G . S

obreira

2 , C.A

. Moreira

3 , M.A

. Aleixo

2 ,

S. Brissos

1

1

Centro Hospitalar Psiquiátrico de Lisboa, Neuropsychiatric and

Dementia Unit, Lisbon, Portugal

2

Centro Hospitalar Psiquiátrico de Lisboa, First Psychotic Episode

Unit, Lisbon, Portugal

3

Centro Hospitalar Psiquiátrico de Lisboa, Schizophrenia and

Schizoaffective Disorders Unit, Lisbon, Portugal

Corresponding author.

Introduction

The finding of prefrontal dysfunction in schizophre-

nia patients with negative symptoms (NS) has raised interest

in using transcranial magnetic stimulation (TMS), which can

modulate prefrontal function and dopamine release, as potential

treatment for NS.

Objective

To briefly review current literature concerning the use

of TMS as treatment for NS.

Aims

To assesswhether current evidence supports the use of TMS

for NS.

Methods

Narrative review of articles found through a PubMed

database search using the keywords “transcranial magnetic stimu-

lation”, “schizophrenia”, and “negative symptoms” between 1998

and 2015.

Results

Up to date, reviews of randomized sham-controlled stud-

ies found positive effects of TMS in NS. However, they exposed

several methodological difficulties. More recent studies, reviewed

in this poster, tried to overcome these, using results from multi-

ple centers, larger samples and blinding. Various TMS techniques

were studied, differing in frequency, motor threshold (MT), stim-

ulus location, and treatment duration. Overall, TMS continues to

show promising results in reducing NS; particularly rTMS 10Hz,

for at least 15 sessions on the left dorsolateral prefrontal cortex

(DLPFC) at a 110% MT.

Conclusions

TMSmay be a useful treatment for NS for patients not

responding to pharmacological treatment alone. Studies remain

difficult to compare due to different measures of outcome (PANSS

and SANS being themost commonly used) and techniques. Further-

more, possible modulators of response include duration of illness,

cognitive symptoms amelioration, medication and their dose, and

different NS may respond differently to TMS. More studies are

needed to better understand the utility of TMS in NS.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.2048

EV1064

Posterior vitreous detachment and

electroconvulsive therapy: Insights

from a case

F. Pavez

, A. Alcántara , N. López , A. García , M. Sánchez ,

M. Roca , E. Moral , J. Russo

Hospital General Universitario Reina Sofía, Psychiatry, Murcia, Spain

Corresponding author.

A case of bilateral posterior vitreous detachment after electrocon-

vulsive therapy (ECT) has been reported previously in the literature.

There is not enough evidence about ocular side effects of this

treatment. The literature supports a slight increase in intraocu-

lar pressure (IOP), although no ocular complications have been

reported in normal, glaucomatous or postsurgical eyes. In this

case report, we describe a 73-year-old female patient suffer-

ing a recurrent depressive disorder, who was admitted to acute

psychiatric unit because a treatment-resistant major depressive

episode (after an adequate trial of antidepressant drugs and tran-

scranial magnetic stimulation) and clinical suspicion of visual

delusions by her reference psychiatrist. The nonpsychiatric his-

tory consisted of hypertension, glaucoma and ulcerative colitis

in treatment with azathioprine and mesalazine. After a careful

examination in the emergency room, we consulted to ophthalmol-

ogist because miodesopsias and glaucoma history. The IOP was

normal, but a bilateral posterior vitreous detachment (PVD) was

identified. Because this entity is not an absolute contraindication

for ECT, and there is scarce evidence, we informed the patient

and her family. After that, and through informed consent, we

decided to undergo ECT. After fourteen sessions, the patient could

be discharged because significant clinical benefit and no ocular

complications. Outpatient continuation ECT was indicated.

Conclusions

ECT can be a safe treatment choice in cases of PVD.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.2049

EV1065

Maintenance electroconvulsive

therapy for catatonia

R. Perez

, M.D.L.D. Perez , A. Hidalgo , J. Prados , C.P. Gonzalez ,

M. Soto , B. Herrejon

Hospital provincial de toledo, Psiquiatría, Toledo, Spain

Corresponding author.

Introduction

We describe a case of a woman admitted to the psy-

chiatric unit with characteristics of excited catatonia. Two years ago

she had an episode of catatonia triggered by social and economic

problems presented with mutism, psychomotor retardation and

compromised oral intake. She recovered with 15 ECT sessions and

was discharged in a stable state on quetiapine, divalproex sodium,

venlafaxine and diazepam. This time she was treated with 13 ECT

sessions and was discharged on previous maintenance treatment.

Three weeks after her condition gradually deteriorated again. She

recovered with 7 ECT sessions and was derived to our ECT mainte-

nance program.

Objective

To describe and discuss the use of maintenance elec-

troconvulsive therapy (m-ECT) in catatonia.

Methods

Clinical case report and PubMed search with the key-

words “catatonia” and “maintenance electroconvulsive therapy”.

Results

Catatonia is characterized by motor disorders, mutism

and negativism, autonomic dysfunction is also possible, sharing

symptoms and severity with neuroleptic malignant syndrome. In

the DSM 5 catatonia is as a specifier of a primary disorder (Tr. Psy-

chotic, affective, substances or unspecified) and not a schizophrenia

subtype. Benzodiazepines are most utilized as first-line treatment

for catatonia, and/or electroconvulsive therapy (ECT). The role of

antipsychotics is unclear. Use of maintenance ECT in responders

appears beneficial.

Conclusion

Catatonia guidelines recommend ECT treatment if

benzodiazepines are not effective. Maintenance ECT is a good

option in long-term prevention of recurrent catatonia. More spe-

cific research is required.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.2050