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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

S687

Results

In H

9

C

2

, asenapine differently modulated NO release and

Ca

2+

movements depending on the peroxidative condition. The Ca

2+

pool mobilized by asenapine mainly originated from the extracel-

lular space and was slightly affected by thapsigargin. Moreover, the

effects of asenapinewere reduced or prevented by kinases blockers,

dopaminergic and serotoninergic receptors inhibitors and voltage

Ca

2+

channels blockers.

Conclusions

On the basis of our findingswe can conclude that ase-

napine by interacting with its specific receptors, exerts dual effects

on NO release and Ca

2+

homeostasis in H

9

C

2

; this would be of par-

ticular clinical relevance, when considering their role in cardiac

function modulation.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.2041

Psychosurgery and stimulation methods (ECT,

TMS, VNS, DBS)

EV1057

A tribute to Johann Gottlieb

Burckhardt-Heussler (1836–1907), the

pioneer of psychosurgery

M. Arts

1 ,

, P. Michielsen

2

, S. Petrykiv

3

, L. de Jonge

1

1

UMCG, Old Age Psychiatry, Groningen, Netherlands

2

GGZWNB, Psychiatry, Bergen op Zoom, Netherlands

3

GGZ Friesland, Emergency Psychiatry, Leeuwarden, Netherlands

Corresponding author.

Introduction

Johann Gottlieb Burckhardt-Heussler was a Swiss

psychiatrist, who pioneered controversial psychosurgical proce-

dures. Burckhardt-Heussler extirpated various brain regions from

six chronic psychiatric patients under his care. By removing corti-

cal tissue he aimed to relieve the patients of symptoms, including

agitation, rather than effect a cure.

Objectives

To present the scientific papers of Johann Gottlieb

Burckhardt-Heussler on psychosurgery.

Aims

To review available literature and to show evidence that

Burckhardt-Heussler made a significant contribution to the devel-

opment of psychosurgery.

Methods

A biography and private papers are presented and dis-

cussed, followed by a literature review.

Results

The theoretical basis of Burckhardt-Heussler’s psy-

chosurgical procedure was influenced by the zeitgeist and based on

his belief that psychiatric illnesses were the result of specific brain

lesions. His findings were ignored by scientists to make them dis-

appear into the mists of time, while the details of his experiments

becamemurky. Decades later, it was the American neurologistWal-

ter Freeman II, performing prefrontal lobotomies since 1936, who

found it inconceivable that the medical community had forgotten

Burckhardt-Heussler and who conceded that he was familiar with,

and probably even influenced by, Burckhardt’s work.

Conclusion

It is partly thanks to Burckhardt-Heussler’s pioneer-

ing work that modern psychosurgery has gradually evolved from

irreversible ablation to reversible stimulation techniques, including

deep brain stimulation.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.2042

EV1058

The Introduction of electroshock in

the Spanish asylum’s practice after the

Spanish civil war

A. Conseglieri Gámez

1 ,

, R. Candela Ramírez

2

,

P. Vázquez de la Torre Escalera

2

1

Hospital Universitario Infanta Cristina, Psiquiatría, Parla, Madrid,

Spain

2

Hospital Universitario de Fuenlabrada, Psiquiatría, Fuenlabrada,

Madrid, Spain

Corresponding author.

Introduction

During the first decade’s of the 20th century, bio-

logical therapies in psychiatry were introduced, amongst them

electroshock (Cerletti and Bini, 1938). The quick reception received

in Spain can be found at the Congreso de la Sociedad Espa˜nola

de Neurología y Psiquiatría (Barcelona, 1942), in journals such

as Actas Espa˜nolas de Neurología y Psiquiatría, or through the

interventions of psychiatrists such as Dr. López Ibor in the Primer

Congreso Internacional de Psiquiatría (París, 1950). On a practical

level, many asylums after the end of the Spanish war used elec-

troshock (Leganés, Navarra, Santa Águeda en Guipúzcoa, Valladolid

y Ciempozuelos) at the same times.

Objectives/aims

Study the Introduction of electroshock in the

Spanish asylum’s practice in the 40s, focusing on the asylum of

Leganés, through the analysis of the technique and its repercussion.

Review journals in the first electroshock’s decade.

Methods

We analyzed 615 clinic histories from the Asylum of

Leganés (1939–1952), and compared themwith other Spanish asy-

lums (SPSSv21). Publications from this decade are reviewed.

Results

This therapy was the most used in the Asylum of Leganés

(46%) and Navarra, occupying a central place in other asylums

(along with Sakel and cardiazoltherapy). Electroshock was easy to

use andhad lowcosts, so the use of other shock therapies decreased.

Conclusions

After the Spanish civil war, electroshock was intro-

duced and used inmost Spanish asylumswithout a big delay in spite

of the war. Many journals have, and continue to, appear regarding

this therapy and it is still used nowadays.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.2043

EV1059

Electroconvulsive therapy outpatient

program recently established in a

psychiatric day hospital

A. Duque Domínguez

1 ,

, R. Duque Domínguez

2

,

C. García Montero

1

, L. Martín Díaz

1

, M. Palomo Monge

3

,

E. Pérez Arévalo

1

, M.D.L.N. Vaquero López

1

, A. Barreiro de Lucas

1

1

Complejo Asistencial de Ávila, Servicio de Psiquiatría, Ávila, Spain

2

Hospital Universitario de Fuenlabrada, Servicio de Psiquiatría,

Madrid, Spain

3

Complejo Hospitalario de Talavera de la Reina, Servicio de

Psiquiatría, Talavera de la Reina Toledo, Spain

Corresponding author.

Introduction

ECT outpatient program recently created in the Psy-

chiatric Day Hospital in Ávila was designed to assess the safety

and efficacy of continuation/maintenance electroconvulsive ther-

apy (ECT) in patients after ECT remission.

Objectives

Description of the activity and objectives of an ECT

outpatient program in a Psychiatric Day Hospital.