European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805 S687
Results In H9C 2, asenapine differently modulated NO release and
Ca2+ movements depending on the peroxidative condition. The Ca2+
pool mobilized by asenapine mainly originated from the extracel-
lular space and was slightly affected by thapsigargin. Moreover, the
effects of asenapinewere reduced or prevented by kinases blockers,
dopaminergic and serotoninergic receptors inhibitors and voltage
Ca2+ channels blockers.
Conclusions On the basis of our findingswe can conclude that ase-
napine by interacting with its specific receptors, exerts dual effects
on NO release and Ca2+ homeostasis in H9C2; this would be of par-
ticular clinical relevance, when considering their role in cardiac
function modulation.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
Psychosurgery and stimulation methods (ECT,
TMS, VNS, DBS)
EV1057
A tribute to Johann Gottlieb
Burckhardt-Heussler (1836–1907), the
pioneer of psychosurgery
M. Arts ∗, P. Michielsen , S. Petrykiv , L. de Jonge
1 UMCG, Old Age Psychiatry, Groningen, Netherlands
2 GGZWNB, Psychiatry, Bergen op Zoom, Netherlands
3 GGZ Friesland, Emergency Psychiatry, Leeuwarden, Netherlands
∗ Corresponding author.
Introduction Johann Gottlieb Burckhardt-Heussler was a Swiss
psychiatrist, who pioneered controversial psychosurgical proce-
dures. Burckhardt-Heussler extirpated various brain regions from
six chronic psychiatric patients under his care. By removing corti-
cal tissue he aimed to relieve the patients of symptoms, including
agitation, rather than effect a cure.
Objectives To present the scientific papers of Johann Gottlieb
Burckhardt-Heussler on psychosurgery.
Aims To review available literature and to show evidence that
Burckhardt-Heussler made a significant contribution to the devel-
opment of psychosurgery.
Methods A biography and private papers are presented and dis-
cussed, followed by a literature review.
Results The theoretical basis of Burckhardt-Heussler’s psy-
chosurgical procedure was influenced by the zeitgeist and based on
his belief that psychiatric illnesses were the result of specific brain
lesions. His findings were ignored by scientists to make them dis-
appear into the mists of time, while the details of his experiments
becamemurky. Decades later, it was the American neurologistWal-
ter Freeman II, performing prefrontal lobotomies since 1936, who
found it inconceivable that the medical community had forgotten
Burckhardt-Heussler and who conceded that he was familiar with,
and probably even influenced by, Burckhardt’s work.
Conclusion It is partly thanks to Burckhardt-Heussler’s pioneer-
ing work that modern psychosurgery has gradually evolved from
irreversible ablation to reversible stimulation techniques, including
deep brain stimulation.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1058
The Introduction of electroshock in
the Spanish asylum’s practice after the
Spanish civil war
A. Conseglieri Gámez ∗, R. Candela Ramírez ,
P. Vázquez de la Torre Escalera
1 Hospital Universitario Infanta Cristina, Psiquiatría, Parla, Madrid,
Spain
2 Hospital Universitario de Fuenlabrada, Psiquiatría, Fuenlabrada,
Madrid, Spain
∗ Corresponding author.
Introduction During the first decade’s of the 20th century, bio-
logical therapies in psychiatry were introduced, amongst them
electroshock (Cerletti and Bini, 1938). The quick reception received
in Spain can be found at the Congreso de la Sociedad Espa˜nola
de Neurología y Psiquiatría (Barcelona, 1942), in journals such
as Actas Espa˜nolas de Neurología y Psiquiatría, or through the
interventions of psychiatrists such as Dr. López Ibor in the Primer
Congreso Internacional de Psiquiatría (París, 1950). On a practical
level, many asylums after the end of the Spanish war used elec-
troshock (Leganés, Navarra, Santa Águeda en Guipúzcoa, Valladolid
y Ciempozuelos) at the same times.
Objectives/aims Study the Introduction of electroshock in the
Spanish asylum’s practice in the 40s, focusing on the asylum of
Leganés, through the analysis of the technique and its repercussion.
Review journals in the first electroshock’s decade.
Methods We analyzed 615 clinic histories from the Asylum of
Leganés (1939–1952), and compared themwith other Spanish asy-
lums (SPSSv21). Publications from this decade are reviewed.
Results This therapy was the most used in the Asylum of Leganés
(46%) and Navarra, occupying a central place in other asylums
(along with Sakel and cardiazoltherapy). Electroshock was easy to
use andhad lowcosts, so the use of other shock therapies decreased.
Conclusions After the Spanish civil war, electroshock was intro-
duced and used inmost Spanish asylumswithout a big delay in spite
of the war. Many journals have, and continue to, appear regarding
this therapy and it is still used nowadays.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV1059
Electroconvulsive therapy outpatient
program recently established in a
psychiatric day hospital
A. Duque Domínguez ∗, R. Duque Domínguez ,
C. García Montero , L. Martín Díaz , M. Palomo Monge ,
E. Pérez Arévalo , M.D.L.N. Vaquero López , A. Barreiro de Lucas
1 Complejo Asistencial de Ávila, Servicio de Psiquiatría, Ávila, Spain
2 Hospital Universitario de Fuenlabrada, Servicio de Psiquiatría,
Madrid, Spain
3 Complejo Hospitalario de Talavera de la Reina, Servicio de
Psiquiatría, Talavera de la Reina Toledo, Spain
∗ Corresponding author.
Introduction ECT outpatient program recently created in the Psy-
chiatric Day Hospital in Ávila was designed to assess the safety
and efficacy of continuation/maintenance electroconvulsive ther-
apy (ECT) in patients after ECT remission.
Objectives Description of the activity and objectives of an ECT
outpatient program in a Psychiatric Day Hospital.