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S616

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1816

EV832

From obsessivity to bipolarity and vice

versa. A literature review

P. Cano Ruiz

1 ,

, S . C

a˜nas Fraile

1 , A.

Gómez Peinado

1 ,

P. Sanmartin Salina

s 2

1

HNSPS, Psychiatric, Albacete, Spain

2

Universidad de Alcalá, Systems Biology, Alcalá de Henares, Spain

Corresponding author.

Introduction

The prevalence of obsessive symptoms in bipolar

patients is currently under discussion. Last years, different cases

of antidepressant-induced mania and hypomania in patients with

OCD have been described.

Several authors have reported that patients with OCD and bipolar

disorder have more depressive episodes than patients with only

OCD.

Objective

To know the relationship between OCD and other bipo-

lar spectrum disorders.

Method

Bibliographical review on comorbidity between obses-

sive symptoms and bipolarity.

Results

Some longitudinal analysis have shown that patients

firstly diagnosed with OCD have an increased risk for subsequent

diagnosis of all other conditions, especially for bipolar and schizoaf-

fective disorder, for those whose risk is of up to 13 times higher.

The handling of a patient with bipolar disorder and OCD implies

some difficulty, because of themain treatment of anxiety disorders,

the antidepressants, alters the course of manic-depressive illness,

accelerating cycles.

Conclusions

OCD is etiologically related to bipolar spectrum dis-

orders and schizophrenia. Therefore, it is necessary to continue the

investigation of possible involved genes and approaches for clinical

practice.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

Further readings

Cederlöf, M., Lichtenstein, P., Larsson, H., Boman, M., Rück,

C., Landén, M., & Mataix-Cols, D. (2014). Obsessive-compulsive

disorder, psychosis, and bipolarity: a longitudinal cohort andmulti-

generational family study. Schizophrenia bulletin, sbu169.

Vega Davila, D. (2010). La complejidad de la comorbilidad:

Trastorno Bipolar y Trastorno Obsesivo Compulsivo. Psiquiatria.

com, 14.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1817

EV833

Dual target repetitive transcranial

magnetic stimulation in the treatment

of comorbid obsessive-compulsive

disorder in patients with anorexia

nervosa: Preliminary results of two

case reports

N. De Schryver

, G.M

.D. Lemmens , C. Baeken ,

D. Van den Abbeele

Universitair Ziekenhuis Gent, Psychiatry, Gent, Belgium

Corresponding author.

Introduction

Obsessive-compulsive disorder (OCD) is a fre-

quently reported comorbid disorder (20–30%) in patients with

anorexia nervosa (AN). Increasing evidence suggests that repet-

itive transcranial magnetic stimulation (r-TMS) may be effective

in the treatment of refractory OCD and to a lesser extent in AN.

Hereby, different target areas: supplemental motor area (SMA) and

orbitofrontal cortex (OFC) and dorsolateral prefrontal cortex in AN.

We report two patients with enduring AN and comorbid treatment

resistant OCD treated with r-TMS.

Methods

Both female patients (34 and 26 years respectively)

were hospitalized at the Eating Disorder Unit at the Ghent Univer-

sityHospital. Treatment responseswere evaluatedwith Yale Brown

Obsessive Compulsive Scale (Y-BOCS) and weight gain. Inhibitory

continuous thetaburst stimulation (cTBS) of the SMA followed by

cTBS of the OFC was conducted during 20 sessions, 5 sessions a

week, during 4 weeks. Stimulation intensity was respectively 100%

and 80% of the motor treshold.

Results

After cTBS treatment Y-BOCS score of both patients

decreased (31 to 24 and 31 to 23 respectively). Only one patient

showed a 10% increase of weight. The treatment was well tolerated.

No significant side effects were reported.

Conclusion

Treatment resistant comorbid OCD in patients with

AN may be succesfully treated with cTBS.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1818

EV834

Reactive anxiety to ruminations of

thinking

T. Delgado Durán

1 ,

, F.J. Márquez Ligero

2

1

Hospital Costa de la Luz, Psychiatry, Huelva, Spain

2

Unidad de Gestión clínica Huelva, Psychiatry, Huelva, Spain

Corresponding author.

The anxiety that accompanies an obsessive-compulsive disorder

with predomination of ruminations of thinking, is a symptom

of elevated prevalence in the population that makes up abstract

labor which accesses for an opposition of hard consecution. The

characteristics of the personality of such patients, like perfection-

ism, control, the analysis of every minimal step they take and of

every decision they make, the difficulty for them to find an unex-

pected event, collaborates so they can have a greater accessibility

to accomplish objectives they contemplate, like the case of opposi-

tions for a position in a farm, court or education. However, as such

objectives are being met, everything evolves correctly, the fact of

not being able to accomplish given purposes, carry on to the appear-

ance of the symptom. Themajority of these patients, such symptom

is anxiety, reaching such intensity, which limits the development

of their daily activities in a correct manner, and in many cases, it

obligates them to resign their position. To develop this case, I will

expose the case of a 50 year old male, a justice professional, with

clinical anxiety of growing intensity in the months previous to the

first interview, appears with a reactive character a ruminations of

thinking by the impossibility of an adequate agreement of the given

working activity. The poster explains how the symptoms appear,

howthey are treated andwhat the evolution of the clinical profile is.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.1819

EV835

Obsession or delusion

T. Delgado Durán

1 ,

, F. J.

Márquez Ligero

2 ,

E. Romero Guerrero

2

1

Huelva, Spain

2

Unidad de Gestión Clínica Huelva, Psychiatry, Huelva, Spain

Corresponding author.

Obsession, in cases, reaches an elevated intensity creating part of a

clear obsessive compulsive disorder with predomination in rumi-

nations of thinking, accompanied by reactive anxiety that such

alterations cause. A narrow line exists that separates such disor-

der with its symptoms accompanied by alterations in the content

of thinking that exists in another syndrome like the persistent