European Psychiatry - Volume 33 - March 2016

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S534 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805
EV576
Cognitive functioning in patients
suffering from anorexia nervosa: A
longitudinal study
G. Rekkedal ∗, U. Kessler , Y. Danielsen , S. Frostad
Haukeland University Hospital, Clinic for psychosomatic medicine,
Bergen, Norway
∗ Corresponding author.
Introduction The majority of research concerning cognitive func-
tioning in eating disorders has focused on the symptomatic phase
of illness in patients suffering from Anorexia Nervosa. There is a
lack of longitudinal studies focusing on the possible effects of cog-
nitive functioning on treatment outcome. Further, only a subgroup
of studies control for the effects of depression and depressive symp-
toms in this field of research.
Objective The main objective of the present study is to examine
cognitive functioning in patients suffering Anorexia in a longitu-
dinal perspective. Secondly, to examine and clarify the effects of
depression on cognitive functioning in patients suffering Anorexia.
Thirdly, the aim is to investigate cognitive functioning in Anorexia
as a possible predictor for treatment outcome and retention.
Methods Patients aged≥ 16 years diagnosed with Anorexia Ner-
vosa, admitted to outpatient treatment (CBT-E) at Section for
Eating Disorders, Haukeland University Hospital, will be recruited
to the study. A healthy control group and a comparison group of
patients diagnosed with first episode major depressive disorder
will also be included. The neuropsychological assessment consists
of a comprehensive test battery including well-established neu-
ropsychological tests known to have good psychometric properties.
Depressive symptoms will be measured by the Montgomery Aas-
berg Depression Rating scale and eating disorder symptoms will
be assessed with the EDE-Q. The neuropsychological assessment
will be performed three times during the study: before treatment,
post treatment and one year after discharge. The assessment will
be performed at the Institute of biological and medical psychology,
Section of clinical neuropsychology, University of Bergen.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV577
Perfectionism, a transdiagnostic
construct in eating disorders
T. Rodriguez Cano ∗, L. Beato Fernandez , B. Mata Saenz ,
L. Rojo Moreno , F.J. Vaz Leal
1 Hospital General Ciudad Real, Psychiatry, Ciudad Real, Spain
2 Universidad de Valencia. HUiP la Fe, Professor of Psychiatry,
Valencia, Spain
3 University of Extremadura Medical School Head. Mental Health and
Eating Disorder Unit. University Hospital Network Badajoz, Professor
of Psychiatry, Badajoz, Spain
∗ Corresponding author.
Introduction Perfectionism is considered a multidimensional key
risk factor for Eating Disorders (EDs). There are discrepancies
regarding if it is mainly associated to Anorexia nervosa (AN) but
not to other EDs.
Objectives To study if Perfectionism is not only related with AN,
but it is present in all EDs and associated withmore transdiagnostic
attitudes and behaviors.
Aims To see if there were significant differences among EDs sub-
groups concerning Perfectionism and to study which abnormal
eating attitudes were more associated with this trait.
Methods Participants were 151 outpatients with EDs. DSM-
IVTR diagnoses were: 44 (29.1%) Anorexia Nervosa (AN), 55
(36.4%) Bulimia Nervosa (BN) and 52 (34.4%) Eating Disorders not
Otherwise Specified (EDNOS). Perfectionism was assessed with
the Edinburg Investigatory Test (EDI-2) subscale; general psy-
chopathology with the Beck Depression Inventory (BDI), State
and Trait Anxiety Inventory (STAI), Rosenberg Self-Esteem Ques-
tionnaire (RSE). Eating psychopathology was measured with the
Bulimic Investigatory Test (BITE), Eating Attitude Test (EAT-40),
EDI-2 and the Body Shape Questionnaire (BSQ).
Results No significant differences were found regarding Perfec-
tionism among the three groups. Body dissatisfaction was the
variable most associated with Perfectionism (ˇ = 0.330, F = 14.2,
P < 0.001, 10.9% of the variance) adjusting for general and eating
psychopathology. Ascetism and Interoceptive awareness were the
EDI-2 subscales most associated with Perfectionism.
Conclusions The findings confirm that Perfectionism is present
in all EDs and there is a relationship between body dissatisfaction
and Perfectionism. Interplay has been suggested between these two
factors for the development of EDs.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV578
A review on pharmacotherapy of
eating disorders
E. Roohi ∗, F. Hashemian
Faculty of Pharmacy, Islamic Azad University, Pharmaceutical
Sciences Branch, Department of Clinical Pharmacy, Tehran, Iran
∗ Corresponding author.
Introduction Eating disorders are identified as chronic debilitat-
ing psychiatric illnesses, which are refractory to treatment in many
patients. The mortality rate associated with eating disorders is
known to be the highest of any psychiatric disorder.
Aims The aim of the present article was to review pharma-
cological treatments available for patients with eating disorders.
Moreover, mechanism of action, dosages and algorithm of use of
the available treatments were discussed. Some optional new treat-
ments undergoing clinical trials were also mentioned.
Methods Studies were identified by searching electronic
databases of Medline, Cochrane Library, and Clinical Trial Regis-
ters. All eligible studies investigating efficacy and safety of the
pharmacological treatments of patients with eating disorders
conducted between 2000 and 2015 were included in the present
article.
Results Current pharmacotherapies include Selective Serotonin
Reuptake Inhibitors (SSRIs), atypical antipsychotics, mood stabi-
lizers, androgen receptor antagonists, serotonin antagonists and
antihistamines. However, level of evidence for pharmacotherapy
of each category of eating disorders are not the same.
Conclusions The use of pharmacotherapy integrated with behav-
ioral and cognitive therapies are recommended. There are still gaps
in the knowledge regarding pharmacotherapy of eating disorders.
Development of agentswithmore efficacy and better safety profiles
are needed.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV579
Eating disorders. Review of current
treatment options for anorexia
nervosa, focused on psychotherapy
and pharmacological treatment
B. Sánchez Sánchez ∗, P. Mu˜noz-Calero Franco ,
N. Rodriguez Criado , J.F. Cruz Fourcade , R. Martín Aragón ,
S. Bravo Herrero , M. García-Poggio Fernández ,
M. Gil-Eliche Moreno , A. De Cos Milas ,
N. Chinchurreta de Lora