European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S349–S805 S533
EV573
Brain changes in anorexia nervosa
G. Gkinis , N. Ortiz ∗, C. Alberque , A. Canuto
HUG, Mental Health and Psychiatry, Geneva, Switzerland
∗ Corresponding author.
Anorexia Nervosa (AN) is a serious and frequent psychiatric condi-
tion with the highest mortality rate within psychiatric diseases. It
often starts during adolescence and affects young patients whose
brainmaturity is still incomplete but brain changes are often under-
considered although AN appears at a critical point of development.
Brain regions involved in the pathophysiology of AN are still in
debate. However, the illness is often associated with enlargement
of the cortical sulci and ventricles as well as with deficits in grey
andwhitematter volumes. Functional modifications have also been
evidenced: mainly global hypometabolism (PET), hypoperfusions
(SPECT) and recent fMRI studies have shown that the function of
the insular and cingulate cortices, in particular, differ in AN.
Neuropsychological studies have also shown neurocognitive
impairments concerning executive functions, episodic andworking
memory as well as attentional deficits.
In 1999, Geneva University Hospitals set up a medical-psychiatric
unit located in the district general hospital. This structure allows
dealing with severe somatic problems as medical and nursing
staffs are psychiatric and somatic specialists. AN patients are
over 16, often hospitalised for the first time and have very low
BMI (< 14). From the clinical observation of these patients who
show significant attentional deficits, we explored whether cerebral
abnormalities were present with structural MRI and Neuropsycho-
logical assessments.
We will describe the preliminary results of our clinical experience
and consider their implication for the understanding of AN mecha-
nisms. We will also discuss the links between psychopathology and
brain impairments that could lead to more efficient treatments.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV574
Disordered eating behaviors,
perfectionism and perseverative
negative thinking–Study in a clinical
sample
A.T. Pereira , E. Monteiro , P. Castilho , L. Fonseca , C. Roque ,
M. Marques , S. Xavier ∗, A. Macedo
1 Faculty of Medicine, University of Coimbra, Psychological Medicine,
Coimbra, Portugal
2 Faculty of Psychology, University of Coimbra, CINEICC, Coimbra,
Portugal
3 Coimbra Hospital and University Centre, Psychiatry, Coimbra,
Portugal
∗ Corresponding author.
Introduction In a recent study developedwith a community sam-
ple, we have found that although PNT mediated the relationship
between perfectionist cognitions and bulimic behavior, the effect
of perfectionism on other disordered eating dimensions, such as
diet, was independent of the PNT levels (Monteiro et al., 2015).
Objective To investigate if PNT mediates the relationship
between perfectionismand disordered eating behaviors in a clinical
sample.
Methods Fifty-two patients with eating disorders/ED (mean
age = 22.54 ± 7.637;meanBMI = 20.07± 4.192; 14.5%AnorexiaNer-
vosa cases; 7.8% Bulimia Nervosa and 9.0% EDNOS) were assessed
with the ED section of the Diagnostic Interview for Genetic
Studies and fill in the Portuguese validated versions of Eat-
ing Attitudes Test/EAT-25 (to evaluate Bulimic behaviors/BB,
Diet and Social pressure to eat), Multidimensional Perfection-
ism Scales (to evaluate perfectionism composite dimensions
Evaluative Concerns/EC and Perfectionistic Strivings/PS) and Per-
severative Thinking Questionnaire/PTQ-15 (to evaluate Repetitive
Thought/RT, Cognitive interference and unproductiveness/CIU).
Only variables significantly correlated with the outcomes (EAT-
25 Total and its dimensions) were entered in the regression
models. Mediation analyses using Preacher and Hayes bootstrap-
ping methodology were performed.
Results EC, PS, CIU and RT were significant predictors of
EAT Total. PA, CIU and PR were significant predictors of BB. EC and
PS were significant predictors of Diet. CIU partially mediated the
relationship between EC and EAT Total (95% CI = 0.0025–0.3296)
and between EC and BB (95% CI = 0.0037–0.1877).
Conclusion Also in a clinical sample, CII, the most pernicious
dimension of PNT, mediates the relationship between perfection-
ism and disordered eating behavior, particularly bulimic behavior;
diet is predicted by perfectionism independently of PNT.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EV575
Psycopathology in overweight and
obese patients
J. Perez-Templado ∗, M.P. Felix-Alcantara , C. Banzo-Arguis ,
R. Martinez de Velasco , E. Ruiz-Velasco , J. Quintero
1 Madrid, Spain
2 Hospital Universitario Infanta Leonor, Psychiatry, Madrid, Spain
3 Hospital Universitario Infanta Leonor & Fundación Psiformación,
Psychiatry, Madrid, Spain
∗ Corresponding author.
Introduction Overweight and obesity are considered as a pan-
demic disease with a worrying prevalence and still growing.
According to theWorld Health Organization, in 2014 the 39% adults
were overweight and 13% were obese. Although it is an objective
fact that obesity is an abnormal or excessive accumulation of fat
detrimental to health, causes that lead a person to be obese are
multifactorial and not yet well known.
Objective Examine the relationship between psychopathology
and obesity. Deepen in this sense, allows us to understand obe-
sity from a broader perspective, where not only the nutritional
factors are involved in these patients, but also different “emotional
profiles”.
Methods The emotional aspects of overweight and the obesity
study Program of the University Hospital Infanta Leonor attends to
these patients from a multi-modal perspective, to offer a multidis-
ciplinary and effective treatment that results in a permanent lost
weight. Descriptive data of the first 180 patients are presented.
Results A large percentage of patients presented psychopathol-
ogy, highlighting a 80.9% of patients with depressive symptoma-
tology, a 56.39% with high anxiety trait, a 48.26% with high anxiety
state, a 24.4%meet criteria for binge eating disorder, a 11.9%bulimia
nervosa and a 17.3% post-traumatic stress disorder.
Conclusion Our findings support the association between obesity
and psychopathology and, therefore, the conception of obesity as a
bio-psycho-social problem requiring a multidisciplinary approach
that go beyond the traditional nutritional guidance.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.