European Psychiatry - Volume 33 - March 2016

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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348 S255
necessary to ask victims of natural disasters about prior traumati-
zation, in particular about prior interpersonal trauma.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW403
Glucocorticoid-based therapeutic
options for PTSD
S. Ouanes
Valais Hospital, Department of Psychiatry and Psychotherapy, Sion,
Switzerland
Introduction PTSD has been associated with HPA axis alterations,
mainly consisting of reduced cortisol levels, elevated CRH and
enhanced glucocorticoid receptor responsiveness. These findings
led to the emergence of glucocorticoid-based therapeutic options
for PTSD.
Objective To outline the different glucocorticoid-based interven-
tions for PTSD either for prophylactic or for curative treatment.
Methods A systematic review was performed. The Medline
databasewas searched using the following keywords: ‘PTSD’, ‘treat-
ment’, ‘Glucocorticoids’, ‘hydrocortisone’.
Results Glucocorticoid-based therapeutic for PTSD comprise
preventive and curative interventions. Preventive interventions
mainly consist of administering one single bolus of hydrocorti-
sone shortly following the exposure to a traumatic event. Evidence
comes from six published trials, all positive. Curative interven-
tions include: prescribing hydrocortisone over short periods of time
to treat PTSD symptoms, using Glucocorticoids to augment psy-
chotherapy (in particular exposure therapy) for PTSD and using
Mifepristone, a glucocorticoid receptor antagonist. Moreover, novel
glucocorticoid receptor modulators are currently being developed
and tested on animal models as a potential curative treatment for
PTSD.
Conclusions Use of hydrocortisone in preventing PTSD might be
tempting, as is the use of hydrocortisone or Glucocorticoid recep-
tors antagonists/modulators in treating PTSD. Yet, it should be
emphasized that these interventions are not mainstream yet. They
rather reflect a revolutionary new direction.
Disclosure of interest The author has not supplied his/her decla-
ration of competing interest.
EW404
Risk factors for post-traumatic stress
disorder – an epidemiological study
B. Pejuskovic ∗, D. Lecic-Tosevski
1 Institute of Mental Health, Department for education, Belgrade,
Serbia
2 Institute of Mental Health, Director, Belgrade, Serbia
∗ Corresponding author.
Introduction Exposure to a traumatic event is necessary but not
sufficient condition for development of posttraumatic stress dis-
order (PTSD). This is evident from the fact that many people who
experience traumatic stressors do not develop this disorder. PTSD is
amulticausal phenomenon and a final end point of the combination
of a number of potential causes.
Objectives To examine the different factors as potential risk fac-
tors for developing PTSD in general adult population.
Methods The sample consisted of 640 subjects, randomly chosen
in five regions of the country. The assessment has been carried out
by MINI-5, Life Stressor Checklist-Revised, Brief Symptom Inven-
tory, and Manchester Short Assessment of Quality of Life scale.
Results Older age, low education and lower monthly income can
predict current PTSD, as well as decreased quality of life, psychiatric
comorbidity and higher personal distress.
Conclusions The risk and resilience factors contribute to the
development/protection of developing PTSD, which is important
for prevention and treatment of this disorder.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW405
Importance of C-PTSD symptoms and
suicide attempt
M. Pinheiro ∗, D. Mendes , T. Mendes , J. Pais , T. Cabral ,
J.C. Rocha
1 Souto, S.M. Feira, Portugal
2 CHTS, DPSM, Penafiel, Portugal
3 CESPU, Psicologia, Paredes, Portugal
∗ Corresponding author.
Introduction Traumatising experiences have been shown to be
important in suicide ideation and attempt. A prolonged and con-
tinuous exposure to stressing interpersonal events can have more
complex consequences. Therefore, the concept of Complex Post-
Traumatic Stress Disorder (C-PTSD) has been emerging.
Objectives Our goal is to relate the symptoms of C-PTSDwith sui-
cide attempt and to evaluate the differences between C-PTSD and
PTSD on those patients. Moreover, we compared our findings with
a control population without prior suicide attempts.
Methods Fifty patients that had been hospitalised in the Psychi-
atry ward following a suicide attempt were evaluated one week
after the event with the ICD-11 Trauma Questionnaire (PTSD and C-
PTSD). The same evaluation was performed on a control population
without known suicide attempts.
Results There is a statistically significant relationship (P < 0.001)
between the symptoms of C-PTSD and PTSD and suicide attempt,
which effect is higher for C-PTSD. These symptoms are almost
absent in the control group.
Conclusion C-PTSD seams to be a more relevant risk factor for
suicidal attempts. This aspect is important to define preventive
and treatment programs and for suicidal attempts follow-up. The
importance of traumatic events and of traumatic stress symptoms
as moderator factors should be considered in future research.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW406
The effect of psychoeducation on
anger management and problem
solving skills of the patients with
post-traumatic stress disorder
M. Senyurt ∗, M. Demiralp , N. Ozmenler , C. Acikel
1 Gulhane Military Medical Academy, Mental Health and Illness,
Ankara, Turkey
2 Gulhane Military Medical Academy, School of Nursing, Ankara,
Turkey
3 Gulhane Military Medical Academy, Biostatistics, Ankara, Turkey
∗ Corresponding author.
This study was conducted as pre-test and post-test experimental
design with the control group in order to identify the effect of psy-
choeducation on anger management and problem solving skills of
the patients with post-traumatic stress disorder. This study was
carried out in Gülhane Military Medical Academy, the department