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24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

S255

necessary to ask victims of natural disasters about prior traumati-

zation, in particular about prior interpersonal trauma.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.520

EW403

Glucocorticoid-based therapeutic

options for PTSD

S. Ouanes

Valais Hospital, Department of Psychiatry and Psychotherapy, Sion,

Switzerland

Introduction

PTSD has been associated with HPA axis alterations,

mainly consisting of reduced cortisol levels, elevated CRH and

enhanced glucocorticoid receptor responsiveness. These findings

led to the emergence of glucocorticoid-based therapeutic options

for PTSD.

Objective

To outline the different glucocorticoid-based interven-

tions for PTSD either for prophylactic or for curative treatment.

Methods

A systematic review was performed. The Medline

databasewas searched using the following keywords: ‘PTSD’, ‘treat-

ment’, ‘Glucocorticoids’, ‘hydrocortisone’.

Results

Glucocorticoid-based therapeutic for PTSD comprise

preventive and curative interventions. Preventive interventions

mainly consist of administering one single bolus of hydrocorti-

sone shortly following the exposure to a traumatic event. Evidence

comes from six published trials, all positive. Curative interven-

tions include: prescribing hydrocortisone over short periods of time

to treat PTSD symptoms, using Glucocorticoids to augment psy-

chotherapy (in particular exposure therapy) for PTSD and using

Mifepristone, a glucocorticoid receptor antagonist. Moreover, novel

glucocorticoid receptor modulators are currently being developed

and tested on animal models as a potential curative treatment for

PTSD.

Conclusions

Use of hydrocortisone in preventing PTSD might be

tempting, as is the use of hydrocortisone or Glucocorticoid recep-

tors antagonists/modulators in treating PTSD. Yet, it should be

emphasized that these interventions are not mainstream yet. They

rather reflect a revolutionary new direction.

Disclosure of interest

The author has not supplied his/her decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.521

EW404

Risk factors for post-traumatic stress

disorder – an epidemiological study

B. Pejuskovic

1 ,

, D. Lecic-Tosevski

2

1

Institute of Mental Health, Department for education, Belgrade,

Serbia

2

Institute of Mental Health, Director, Belgrade, Serbia

Corresponding author.

Introduction

Exposure to a traumatic event is necessary but not

sufficient condition for development of posttraumatic stress dis-

order (PTSD). This is evident from the fact that many people who

experience traumatic stressors do not develop this disorder. PTSD is

amulticausal phenomenon and a final end point of the combination

of a number of potential causes.

Objectives

To examine the different factors as potential risk fac-

tors for developing PTSD in general adult population.

Methods

The sample consisted of 640 subjects, randomly chosen

in five regions of the country. The assessment has been carried out

by MINI-5, Life Stressor Checklist-Revised, Brief Symptom Inven-

tory, and Manchester Short Assessment of Quality of Life scale.

Results

Older age, low education and lower monthly income can

predict current PTSD, as well as decreased quality of life, psychiatric

comorbidity and higher personal distress.

Conclusions

The risk and resilience factors contribute to the

development/protection of developing PTSD, which is important

for prevention and treatment of this disorder.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.522

EW405

Importance of C-PTSD symptoms and

suicide attempt

M. Pinheiro

1 ,

, D. Mendes

2

, T. Mendes

3

, J. Pais

2

, T. Cabral

2

,

J.C. Rocha

3

1

Souto, S.M. Feira, Portugal

2

CHTS, DPSM, Penafiel, Portugal

3

CESPU, Psicologia, Paredes, Portugal

Corresponding author.

Introduction

Traumatising experiences have been shown to be

important in suicide ideation and attempt. A prolonged and con-

tinuous exposure to stressing interpersonal events can have more

complex consequences. Therefore, the concept of Complex Post-

Traumatic Stress Disorder (C-PTSD) has been emerging.

Objectives

Our goal is to relate the symptoms of C-PTSDwith sui-

cide attempt and to evaluate the differences between C-PTSD and

PTSD on those patients. Moreover, we compared our findings with

a control population without prior suicide attempts.

Methods

Fifty patients that had been hospitalised in the Psychi-

atry ward following a suicide attempt were evaluated one week

after the event with the ICD-11 Trauma Questionnaire (PTSD and C-

PTSD). The same evaluation was performed on a control population

without known suicide attempts.

Results

There is a statistically significant relationship (

P

< 0.001)

between the symptoms of C-PTSD and PTSD and suicide attempt,

which effect is higher for C-PTSD. These symptoms are almost

absent in the control group.

Conclusion

C-PTSD seams to be a more relevant risk factor for

suicidal attempts. This aspect is important to define preventive

and treatment programs and for suicidal attempts follow-up. The

importance of traumatic events and of traumatic stress symptoms

as moderator factors should be considered in future research.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.523

EW406

The effect of psychoeducation on

anger management and problem

solving skills of the patients with

post-traumatic stress disorder

M. Senyurt

1 ,

, M. Demiralp

2

, N. Ozmenler

1

, C. Acikel

3

1

Gulhane Military Medical Academy, Mental Health and Illness,

Ankara, Turkey

2

Gulhane Military Medical Academy, School of Nursing, Ankara,

Turkey

3

Gulhane Military Medical Academy, Biostatistics, Ankara, Turkey

Corresponding author.

This study was conducted as pre-test and post-test experimental

design with the control group in order to identify the effect of psy-

choeducation on anger management and problem solving skills of

the patients with post-traumatic stress disorder. This study was

carried out in Gülhane Military Medical Academy, the department