European Psychiatry - Volume 33 - March 2016

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S254 24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348
Keywords Post-traumatic stress disorder; Quality of life; Gas
pipeline explosion Fern-Mashhad
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW400
Russian–Georgian war crimes and its
outcomes
M. Jishkariani
The International Psycho, Rehabilitation Centre for Victims of torture
“Empathy”, Treatment and Rehabilitation Department, Tbilisi,
Georgia
Introduction Georgia is the Country located in Caucasian Region
with two occupied territories: Abkhazia and South Ossetia. Since
1993 as a result ofmilitary actions 500,000 civilians became victims
of ethnic cleansing. In October 13, 2015 the Prosecutor of the Inter-
national Criminal Court, requests judges for authorization to open
an investigation into the Situation in Georgia that clearly shows
importance of the problem addressed by this study.
Objectives of the study includes Observation of outcomes of trau-
matic stress among three categories of victims: IDPs, population
living in themilitary conflict zone and civilians living in the so called
“Buffer Zone”. Aimof the studywas to provide comparative analysis
between trauma affected different groups.
Methods The clinical and paraclinical methods using the
semi–structured clinical interview, psychological test battery and
paraclinical diagnostic tests were used, analysis were provided by
using the SPSS.
Results Based on observation in2014–2015 n = 150 victims ofwar
crimeswere observed. Also additional stressors for all target groups
were identified. Differences and similarities of psychological and
somatic after effects of trauma revealed.
Conclusions We can conclude that prolonged stress situation
with unsecured environment and daily life under unexpected cir-
cumstances caused prolongation of PTSD alongside of behavioral
changes and with damages in social adaptation. On the other hand
completed traumawith leaving of native living areas and significant
changes in social life in most of cases caused emotional distur-
bances with prolonged chronic depression and persistent fillings
of grief.
Disclosure of interest The author has not supplied his/her decla-
ration of competing interest.
EW401
Association of pro-inflammatory
cytokines with PTSd severity in
patients treated with omega-3
supplementation – a pilot study
D. Kalini´c ∗, N. Mimica , A. Jeroncic , M. Lalovac , I. Delaˇs
1 University of Zagreb School of Medicine, Department of Psychiatry
and Psychological Medicine, Zagreb, Croatia
2 University of Split School of Medicine, Department of Research in
Biomedicine and Health, Split, Croatia
3 Clinical Hospital Merkur, Department of Internal Medicine, Zagreb,
Croatia
4 University of Zagreb School of Medicine, Department of Chemistry
and Biochemistry, Zagreb, Croatia
∗ Corresponding author.
Introduction Association of pro-inflammatory cytokines with
severity of various psychiatric disorders is shown. Evidence sug-
gests omega-3 fatty acids reduce psychiatric symptoms due to
anti-inflammatory properties.
Objectives To evaluate if serum levels of pro-inflammatory
cytokines correlate with the intensity of PTSD symptoms, and
the observed change in symptoms’ severity induced by omega-3
supplementation.
Methods We included 26 Croatian Homeland war veterans (aged
39–60) with chronic PTSD and no major comorbidity, who were
on stable therapeutic sertraline dose at least three months before
recruitment. Levels of pro-inflammatory cytokines (TNF- , IL-6,
and IL-1 )were determined by the enzyme-linked immunosorbent
assay method. Intensity of PTSD symptomatology was assessed by
Clinician-Administered PTSD Scale (CAPS), Hamilton Anxiety Scale
(HAM-A) and 17-item Hamilton Depression Scale (17-HAM-D).
During 12weeks, participants took omega-3 capsules (600mg/day)
while continuing sertraline therapy.
Results Most participants presented with moderate PTSD eval-
uated by CAPS. At baseline, cytokine levels were not associated
with the severity of PTSD symptoms, as measured by all three
scales (P ≥ 0.209). After 12weeks of omega-3 supplementation the
severity of PTSD symptoms significantly decreased, on average
by 8 to 13% on the psychometric scales per person ( P < 0.001 for
all). However, no association was found between the change in
cytokine levels and the change in scores, induced by omega-3, on
the assessed scales ( P ≥ 0.730).
Summary Cytokine levels are not associated with PTSD severity
or with improvement in PTSD symptomatology. At the same time,
sertraline therapy supplemented with omega-3 seemed to reduce
the severity of PTSD symptoms.
Disclosure of interest The authors have not supplied their decla-
ration of competing interest.
EW402
The “building block” effect of prior
trauma for psychological outcome in
victims of a natural disaster
B. Kraemer ∗ chumacher inkel mboden
L. Wittmann
1 Psychiatric Services Solothurn, Department of Psychiatry,
Solothurn, Switzerland
2 University Hospital, Department of Psychiatry, Zurich, Switzerland
3 International Psychoanalytic University, Psychoanalysis, Berlin,
Germany
∗ Corresponding author.
Background With increasing numbers of previous traumatic
experiences, a rising risk of psychiatric morbidity and in partic-
ular post-traumatic stress disorder following an acute trauma has
been reported. This dose-effect relationshipwas called the building
block effect. Most results are derived from studies on riot and pros-
ecution victims. We investigated victims of a natural disaster with
respect to the building block effect due to prior traumatization.
Methods We assessed tourists who had been affected by the
Indian Ocean Tsunami 2004 using the Post-traumatic Diagnostic
Scale, the Hospital Anxiety and Depression Scale, and the Post-
traumatic Growth Inventory. Outcome variables were related to
the numbers or prior civil trauma according to the trauma history
scale of the PDS.
Results We found a building block effect for the development of
anxiety (P= 0.018) and by trend with PTSD symptoms ( P = 0.06),
but not with depressive symptoms (P = 0.436). Prior traumatization
and the actual Tsunami exposure significantly explained variance
of personal posttraumatic growth (P = 0.013). Prior interpersonal
traumata emerged as a strong risk factor for the development of
posttraumatic psychiatric morbidity.
Conclusions We suggest that an increasing number of trauma
is closely associated with anxiety but not with depressive disor-
ders in the aftermath of natural disasters. For clinical practice, it is