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S254

24th European Congress of Psychiatry / European Psychiatry 33S (2016) S116–S348

Keywords

Post-traumatic stress disorder; Quality of life; Gas

pipeline explosion Fern-Mashhad

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.517

EW400

Russian–Georgian war crimes and its

outcomes

M. Jishkariani

The International Psycho, Rehabilitation Centre for Victims of torture

“Empathy”, Treatment and Rehabilitation Department, Tbilisi,

Georgia

Introduction

Georgia is the Country located in Caucasian Region

with two occupied territories: Abkhazia and South Ossetia. Since

1993 as a result ofmilitary actions 500,000 civilians became victims

of ethnic cleansing. In October 13, 2015 the Prosecutor of the Inter-

national Criminal Court, requests judges for authorization to open

an investigation into the Situation in Georgia that clearly shows

importance of the problem addressed by this study.

Objectives of the study includes

Observation of outcomes of trau-

matic stress among three categories of victims: IDPs, population

living in themilitary conflict zone and civilians living in the so called

“Buffer Zone”. Aimof the studywas to provide comparative analysis

between trauma affected different groups.

Methods

The clinical and paraclinical methods using the

semi–structured clinical interview, psychological test battery and

paraclinical diagnostic tests were used, analysis were provided by

using the SPSS.

Results

Based on observation in2014–2015

n

= 150 victims ofwar

crimeswere observed. Also additional stressors for all target groups

were identified. Differences and similarities of psychological and

somatic after effects of trauma revealed.

Conclusions

We can conclude that prolonged stress situation

with unsecured environment and daily life under unexpected cir-

cumstances caused prolongation of PTSD alongside of behavioral

changes and with damages in social adaptation. On the other hand

completed traumawith leaving of native living areas and significant

changes in social life in most of cases caused emotional distur-

bances with prolonged chronic depression and persistent fillings

of grief.

Disclosure of interest

The author has not supplied his/her decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.518

EW401

Association of pro-inflammatory

cytokines with PTSd severity in

patients treated with omega-3

supplementation – a pilot study

D. Kalini´c

1 ,

, N. Mimica

1

, A. Jeroncic

2

, M. Lalovac

3

, I. Delaˇs

4

1

University of Zagreb School of Medicine, Department of Psychiatry

and Psychological Medicine, Zagreb, Croatia

2

University of Split School of Medicine, Department of Research in

Biomedicine and Health, Split, Croatia

3

Clinical Hospital Merkur, Department of Internal Medicine, Zagreb,

Croatia

4

University of Zagreb School of Medicine, Department of Chemistry

and Biochemistry, Zagreb, Croatia

Corresponding author.

Introduction

Association of pro-inflammatory cytokines with

severity of various psychiatric disorders is shown. Evidence sug-

gests omega-3 fatty acids reduce psychiatric symptoms due to

anti-inflammatory properties.

Objectives

To evaluate if serum levels of pro-inflammatory

cytokines correlate with the intensity of PTSD symptoms, and

the observed change in symptoms’ severity induced by omega-3

supplementation.

Methods

We included 26 Croatian Homeland war veterans (aged

39–60) with chronic PTSD and no major comorbidity, who were

on stable therapeutic sertraline dose at least three months before

recruitment. Levels of pro-inflammatory cytokines (TNF- , IL-6,

and IL-1 )were determined by the enzyme-linked immunosorbent

assay method. Intensity of PTSD symptomatology was assessed by

Clinician-Administered PTSD Scale (CAPS), Hamilton Anxiety Scale

(HAM-A) and 17-item Hamilton Depression Scale (17-HAM-D).

During 12weeks, participants took omega-3 capsules (600mg/day)

while continuing sertraline therapy.

Results

Most participants presented with moderate PTSD eval-

uated by CAPS. At baseline, cytokine levels were not associated

with the severity of PTSD symptoms, as measured by all three

scales (

P

0.209). After 12weeks of omega-3 supplementation the

severity of PTSD symptoms significantly decreased, on average

by 8 to 13% on the psychometric scales per person (

P

< 0.001 for

all). However, no association was found between the change in

cytokine levels and the change in scores, induced by omega-3, on

the assessed scales (

P

0.730).

Summary

Cytokine levels are not associated with PTSD severity

or with improvement in PTSD symptomatology. At the same time,

sertraline therapy supplemented with omega-3 seemed to reduce

the severity of PTSD symptoms.

Disclosure of interest

The authors have not supplied their decla-

ration of competing interest.

http://dx.doi.org/10.1016/j.eurpsy.2016.01.519

EW402

The “building block” effect of prior

trauma for psychological outcome in

victims of a natural disaster

B. Kraemer

1 ,

, S . S

chumacher

2 , B. W

inkel

2 , C. I

mboden

1 ,

L. Wittmann

3

1

Psychiatric Services Solothurn, Department of Psychiatry,

Solothurn, Switzerland

2

University Hospital, Department of Psychiatry, Zurich, Switzerland

3

International Psychoanalytic University, Psychoanalysis, Berlin,

Germany

Corresponding author.

Background

With increasing numbers of previous traumatic

experiences, a rising risk of psychiatric morbidity and in partic-

ular post-traumatic stress disorder following an acute trauma has

been reported. This dose-effect relationshipwas called the building

block effect. Most results are derived from studies on riot and pros-

ecution victims. We investigated victims of a natural disaster with

respect to the building block effect due to prior traumatization.

Methods

We assessed tourists who had been affected by the

Indian Ocean Tsunami 2004 using the Post-traumatic Diagnostic

Scale, the Hospital Anxiety and Depression Scale, and the Post-

traumatic Growth Inventory. Outcome variables were related to

the numbers or prior civil trauma according to the trauma history

scale of the PDS.

Results

We found a building block effect for the development of

anxiety (

P

= 0.018) and by trend with PTSD symptoms (

P

= 0.06),

but not with depressive symptoms (

P

= 0.436). Prior traumatization

and the actual Tsunami exposure significantly explained variance

of personal posttraumatic growth (

P

= 0.013). Prior interpersonal

traumata emerged as a strong risk factor for the development of

posttraumatic psychiatric morbidity.

Conclusions

We suggest that an increasing number of trauma

is closely associated with anxiety but not with depressive disor-

ders in the aftermath of natural disasters. For clinical practice, it is